Invention Grant
- Patent Title: Carbocyclic sulfone RORγ modulators
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Application No.: US15109741Application Date: 2015-01-05
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Publication No.: US09771320B2Publication Date: 2017-09-26
- Inventor: Jingwu Duan , T. G. Murali Dhar , Bin Jiang , Zhonghui Lu , Ananta Karmakar , Arun Kumar Gupta , Carolyn A. Weigelt
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Elliott Korsen
- International Application: PCT/US2015/010085 WO 20150105
- International Announcement: WO2015/103508 WO 20150719
- Main IPC: C07C317/14
- IPC: C07C317/14 ; C07D213/81 ; C07D401/04 ; C07D237/08 ; C07C317/20 ; C07C317/30 ; C07C317/46 ; C07D471/04 ; C07D213/30 ; C07D213/56 ; C07D309/04 ; C07D309/14 ; C07D317/44 ; C07D231/12 ; C07D239/38 ; C07D241/12 ; C07D471/10 ; C07D257/04 ; C07D261/08 ; C07D263/32 ; C07D271/06 ; C07D211/36 ; C07D295/16 ; C07D295/20 ; C07D303/06 ; C07D305/14 ; C07D205/04 ; C07D211/62 ; C07D213/40 ; C07D213/75 ; C07D295/155 ; C07D295/108 ; C07D319/20 ; C07D285/06 ; C07D295/18 ; C07D295/22 ; C07D303/34 ; C07C317/22 ; C07C317/44 ; C07C317/32 ; C07C317/50 ; C07D213/85 ; C07D295/185

Abstract:
Described are RORγ modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
Public/Granted literature
- US20160326103A1 CARBOCYCLIC SULFONE ROR GAMMA MODULATORS Public/Granted day:2016-11-10
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