Invention Grant
- Patent Title: Aromatic compounds with GPR40 agonistic activity
-
Application No.: US14898633Application Date: 2014-08-08
-
Publication No.: US09776962B2Publication Date: 2017-10-03
- Inventor: Jumpei Aida , Yayoi Yoshitomi , Yuko Hitomi , Naoyoshi Noguchi , Yasuhiro Hirata , Hideki Furukawa , Akito Shibuya , Koji Watanabe , Yasufumi Miyamoto , Tomohiro Okawa , Nobuyuki Takakura , Seiji Miwatashi
- Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- Applicant Address: JP Osaka
- Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- Current Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- Current Assignee Address: JP Osaka
- Agency: Nath, Goldberg & Meyer
- Agent Joshua B. Goldberg; Scott H. Blackman
- Priority: JP2013-167065 20130809
- International Application: PCT/JP2014/070972 WO 20140808
- International Announcement: WO2015/020184 WO 20150212
- Main IPC: C07D211/34
- IPC: C07D211/34 ; C07D211/22 ; C07D213/30 ; C07D401/10 ; C07D401/12 ; C07D401/14 ; C07D405/12 ; C07D405/14 ; C07D409/12 ; C07D413/10 ; C07D413/14

Abstract:
Provided is a novel aromatic ring compound having a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity and a GLP-1 secretagogue action, is useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and affords superior efficacy.
Public/Granted literature
- US20160115128A1 AROMATIC COMPOUND Public/Granted day:2016-04-28
Information query