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公开(公告)号：US20150018422A1
公开(公告)日：2015-01-15
申请号：US14377953
申请日：2013-02-12
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Seiji Miwatashi , Hideo Suzuki , Tomohiro Okawa , Yasufumi Miyamoto , Takeshi Yamasaki , Yuko Hitomi , Yasuhiro Hirata , Akito Shibuya
IPC: C07C59/135
CPC classification number: C07C59/135 , C07C59/68 , C07C59/70 , C07C59/72 , C07C229/34 , C07C233/47 , C07C235/34 , C07C255/37 , C07C255/41 , C07C255/46 , C07C309/65 , C07C309/66 , C07C311/21 , C07C317/44 , C07C323/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/12 , C07D213/30 , C07D213/55 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/69 , C07D231/12 , C07D239/26 , C07D239/34 , C07D271/10 , C07D277/24 , C07D285/12 , C07D309/06 , C07D333/38 , C07D401/04 , C07D401/12 , C07D405/12 , C07D405/14
Abstract: Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.
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公开(公告)号：US10968231B2
公开(公告)日：2021-04-06
申请号：US16497141
申请日：2018-03-29
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED , SCOHIA PHARMA, INC
Inventor： Seiji Miwatashi , Yasufumi Miyamoto , Koji Watanabe , Yayoi Nakayama , Yuko Hitomi , Jumpei Aida , Nobuyuki Takakura , Hideki Furukawa , Naoyoshi Noguchi , Yasuhiro Hirata , Shizuo Kasai , Toshitake Kobayashi , Tsuyoshi Maekawa , Satoshi Sasaki , Shigemitsu Matsumoto
IPC: C07D491/052 , C07D211/22 , C07D401/12 , C07D401/14
Abstract: Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy.
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Patent Agency Ranking
公开(公告)号：US09382188B2
公开(公告)日：2016-07-05
申请号：US14377953
申请日：2013-02-12
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Seiji Miwatashi , Hideo Suzuki , Tomohiro Okawa , Yasufumi Miyamoto , Takeshi Yamasaki , Yuko Hitomi , Yasuhiro Hirata , Akito Shibuya
IPC: C07C59/135 , C07D405/14 , C07C255/46 , C07D309/06 , C07D231/12 , C07D333/38 , C07D401/12 , C07D239/26 , C07D239/34 , C07C317/44 , C07C229/34 , C07C233/47 , C07D271/10 , C07D277/24 , C07C255/37 , C07D285/12 , C07D213/30 , C07D213/55 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/69 , C07C59/68 , C07C59/70 , C07C59/72 , C07D213/12 , C07C309/65 , C07C309/66 , C07C311/21 , C07C323/56 , C07C235/34 , C07C255/41
CPC classification number: C07C59/135 , C07C59/68 , C07C59/70 , C07C59/72 , C07C229/34 , C07C233/47 , C07C235/34 , C07C255/37 , C07C255/41 , C07C255/46 , C07C309/65 , C07C309/66 , C07C311/21 , C07C317/44 , C07C323/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/12 , C07D213/30 , C07D213/55 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/69 , C07D231/12 , C07D239/26 , C07D239/34 , C07D271/10 , C07D277/24 , C07D285/12 , C07D309/06 , C07D333/38 , C07D401/04 , C07D401/12 , C07D405/12 , C07D405/14
Abstract: Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.
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公开(公告)号：US20150045378A1
公开(公告)日：2015-02-12
申请号：US14377951
申请日：2013-02-12
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Seiji Miwatashi , Hideo Suzuki , Tomohiro Okawa , Yasufumi Miyamoto , Takeshi Yamasaki , Yuko Hitomi , Yasuhiro Hirata
IPC: C07D213/64 , C07D403/12 , C07D405/14 , C07D401/12 , C07D213/55
CPC classification number: C07D213/64 , C07D213/30 , C07D213/55 , C07D213/68 , C07D213/69 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/14
Abstract: Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.
Abstract translation: 提供具有GPR40激动剂活性的芳环化合物。 由式（I）表示的化合物：其中每个符号如说明书所述，或其盐具有GPR40激动剂活性，并且可用作预防或治疗糖尿病等的药剂。
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公开(公告)号：US11186565B2
公开(公告)日：2021-11-30
申请号：US16499432
申请日：2018-03-29
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Seiji Miwatashi , Yasufumi Miyamoto , Koji Watanabe , Yayoi Nakayama , Yuko Hitomi , Jumpei Aida , Nobuyuki Takakura , Hideki Furukawa , Naoyoshi Noguchi , Yasuhiro Hirata , Kazuaki Takami , Norihito Tokunaga , Tomohiro Okawa , Akito Shibuya , Shizuo Kasai , Toshitake Kobayashi , Tsuyoshi Maekawa
IPC: C07D401/12 , C07C59/72 , C07D211/22 , C07D213/64 , C07D401/10 , C07D401/14 , C07D413/10
Abstract: Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy.
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公开(公告)号：US09776962B2
公开(公告)日：2017-10-03
申请号：US14898633
申请日：2014-08-08
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Jumpei Aida , Yayoi Yoshitomi , Yuko Hitomi , Naoyoshi Noguchi , Yasuhiro Hirata , Hideki Furukawa , Akito Shibuya , Koji Watanabe , Yasufumi Miyamoto , Tomohiro Okawa , Nobuyuki Takakura , Seiji Miwatashi
IPC: C07D211/34 , C07D211/22 , C07D213/30 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D413/14
CPC classification number: C07D211/34 , C07D211/22 , C07D213/30 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D413/14
Abstract: Provided is a novel aromatic ring compound having a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity and a GLP-1 secretagogue action, is useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and affords superior efficacy.
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公开(公告)号：US09181186B2
公开(公告)日：2015-11-10
申请号：US14377951
申请日：2013-02-12
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Seiji Miwatashi , Hideo Suzuki , Tomohiro Okawa , Yasufumi Miyamoto , Takeshi Yamasaki , Yuko Hitomi , Yasuhiro Hirata
IPC: C07D213/64 , C07D405/14 , C07D401/12 , C07D239/34 , C07D213/30 , C07D213/68 , C07D213/69 , C07D213/55 , C07D403/12
CPC classification number: C07D213/64 , C07D213/30 , C07D213/55 , C07D213/68 , C07D213/69 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/14
Abstract: Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.
Abstract translation: 提供具有GPR40激动剂活性的芳环化合物。 由式（I）表示的化合物：其中每个符号如说明书所述，或其盐具有GPR40激动剂活性，并且可用作预防或治疗糖尿病等的药剂。
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