Invention Application
- Patent Title: INHIBITORS OF alpha 4 beta 1 MEDIATED CELL ADHESION
- Patent Title (中): α4β1介导的细胞粘附抑制剂
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Application No.: PCT/US9930665Application Date: 1999-12-20
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Publication No.: WO0037429A2Publication Date: 2000-06-29
- Inventor: TEEGARDEN BRADLEY R , JAYAKUMAR HONNAPPA , MATSUKI KENJI , CHRUSCIEL ROBERT A , FISHER JED F , TANIS STEVEN P , THOMAS EDWARD W , BLINN JAMES R
- Applicant: TANABE SEIYAKU CO , UPJOHN CO , TEEGARDEN BRADLEY R , JAYAKUMAR HONNAPPA , MATSUKI KENJI , CHRUSCIEL ROBERT A , FISHER JED F , TANIS STEVEN P , THOMAS EDWARD W , BLINN JAMES R
- Assignee: TANABE SEIYAKU CO,UPJOHN CO,TEEGARDEN BRADLEY R,JAYAKUMAR HONNAPPA,MATSUKI KENJI,CHRUSCIEL ROBERT A,FISHER JED F,TANIS STEVEN P,THOMAS EDWARD W,BLINN JAMES R
- Current Assignee: TANABE SEIYAKU CO,UPJOHN CO,TEEGARDEN BRADLEY R,JAYAKUMAR HONNAPPA,MATSUKI KENJI,CHRUSCIEL ROBERT A,FISHER JED F,TANIS STEVEN P,THOMAS EDWARD W,BLINN JAMES R
- Priority: US11350198 1998-12-22
- Main IPC: C07D295/04
- IPC: C07D295/04 ; A61K31/198 ; A61K31/22 ; A61K31/36 ; A61K31/401 ; A61K31/44 ; A61K31/445 ; A61K31/472 ; A61K31/5375 ; A61K38/00 ; A61P1/04 ; A61P9/10 ; A61P11/06 ; A61P17/06 ; A61P27/02 ; A61P29/00 ; A61P37/08 ; C07C233/87 ; C07C235/12 ; C07C235/20 ; C07C235/74 ; C07C235/78 ; C07C235/82 ; C07C235/84 ; C07C237/24 ; C07C237/36 ; C07C237/42 ; C07C255/31 ; C07C275/26 ; C07C275/42 ; C07C323/62 ; C07D207/16 ; C07D211/60 ; C07D211/62 ; C07D213/64 ; C07D213/65 ; C07D213/81 ; C07D213/82 ; C07D215/48 ; C07D217/16 ; C07D231/14 ; C07D237/14 ; C07D277/06 ; C07D295/215 ; C07D307/24 ; C07D307/71 ; C07D317/58 ; C07K5/02 ; C07K5/06 ; C07K5/065 ; C07K5/078 ; C07K5/097 ; C07C235/00
Abstract:
The present invention relates to small molecules according to formula (I) which are potent inhibitors of a alpha 4 beta 1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing alpha 4 beta 1 adhesion mediated conditions in a mammal such as a human.
Information query
