Invention Application
- Patent Title: NEUROPROTECTIVE COMPOUNDS AND METHODS OF USE THEREOF
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Application No.: PCT/US2020/053486Application Date: 2020-09-30
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Publication No.: WO2021067405A1Publication Date: 2021-04-08
- Inventor: DAWSON, Ted, M. , DAWSON, Valina, L. , LIU, Jun , PARK, Hyejin , KAM, Tae-In , PENG, Hanjing , AYINAMPUDI, Venkata, Subbarao
- Applicant: THE JOHNS HOPKINS UNIVERSITY
- Applicant Address: 3400 N. Charles Street Street
- Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee Address: 3400 N. Charles Street Street
- Agency: HAILE, Lisa, A. et al.
- Priority: US62/908,954 2019-10-01
- Main IPC: C07D498/04
- IPC: C07D498/04 ; C07D498/14 ; C07F9/32
Abstract:
The present disclosure provides neuroprotective compounds along with their use in treating disease such as Parkinson's disease (PD). The compounds can be used as inhibitors for Parthanatos Associated AIF (apoptosis-inducing factor) Nuclease (PAAN), also known as macrophage migration inhibitor factor (MIF).
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