公开(公告)号：WO2021041573A2

公开(公告)日：2021-03-04

申请号：PCT/US2020/048045

申请日：2020-08-26

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： DAWSON, Ted, M. ,  ROSENTHAL, Liana ,  BRAHMACHARI, Saurav ,  KAM, Tae-In ,  DAWSON, Valina, L.

IPC: G01N33/68 ,  G01N33/53 ,  C07K14/47 ,  A61P25/00 ,  C12Q1/6883 ,  G01N2800/28 ,  G01N2800/2835 ,  G01N2800/52 ,  G01N33/5076 ,  G01N33/6896

Abstract: The invention relates to methods for diagnosis, monitoring progression, and treatment of neurodegenerative disorders. In particular, biomarkers for diagnosis, monitoring progression, and treatment of neurodegenerative disorders are provided. In some embodiments, methods for diagnosis, monitoring progression, and treatment of synucleinopathies and related disorders are provided.

公开(公告)号：WO2021067405A1

公开(公告)日：2021-04-08

申请号：PCT/US2020/053486

申请日：2020-09-30

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： DAWSON, Ted, M. ,  DAWSON, Valina, L. ,  LIU, Jun ,  PARK, Hyejin ,  KAM, Tae-In ,  PENG, Hanjing ,  AYINAMPUDI, Venkata, Subbarao

IPC: C07D498/04 ,  C07D498/14 ,  C07F9/32

Abstract: The present disclosure provides neuroprotective compounds along with their use in treating disease such as Parkinson's disease (PD). The compounds can be used as inhibitors for Parthanatos Associated AIF (apoptosis-inducing factor) Nuclease (PAAN), also known as macrophage migration inhibitor factor (MIF).