公开(公告)号：WO2021041573A2

公开(公告)日：2021-03-04

申请号：PCT/US2020/048045

申请日：2020-08-26

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： DAWSON, Ted, M. ,  ROSENTHAL, Liana ,  BRAHMACHARI, Saurav ,  KAM, Tae-In ,  DAWSON, Valina, L.

IPC: G01N33/68 ,  G01N33/53 ,  C07K14/47 ,  A61P25/00 ,  C12Q1/6883 ,  G01N2800/28 ,  G01N2800/2835 ,  G01N2800/52 ,  G01N33/5076 ,  G01N33/6896

Abstract: The invention relates to methods for diagnosis, monitoring progression, and treatment of neurodegenerative disorders. In particular, biomarkers for diagnosis, monitoring progression, and treatment of neurodegenerative disorders are provided. In some embodiments, methods for diagnosis, monitoring progression, and treatment of synucleinopathies and related disorders are provided.

公开(公告)号：WO2021067405A1

公开(公告)日：2021-04-08

申请号：PCT/US2020/053486

申请日：2020-09-30

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： DAWSON, Ted, M. ,  DAWSON, Valina, L. ,  LIU, Jun ,  PARK, Hyejin ,  KAM, Tae-In ,  PENG, Hanjing ,  AYINAMPUDI, Venkata, Subbarao

IPC: C07D498/04 ,  C07D498/14 ,  C07F9/32

Abstract: The present disclosure provides neuroprotective compounds along with their use in treating disease such as Parkinson's disease (PD). The compounds can be used as inhibitors for Parthanatos Associated AIF (apoptosis-inducing factor) Nuclease (PAAN), also known as macrophage migration inhibitor factor (MIF).

公开(公告)号：WO1995020952A1

公开(公告)日：1995-08-10

申请号：PCT/US1995001189

申请日：1995-02-02

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  THE UNITED STATES OF AMERICA, NATIONAL INSTITUTE ON DRUG ABUSE, ADDICTION RESEARCH CENTER

Inventor： THE JOHNS HOPKINS UNIVERSITY ,  THE UNITED STATES OF AMERICA, NATIONAL INSTITUTE ON DRUG ABUSE, ADDICTION RESEARCH CENTER ,  ZHANG, Jie ,  DAWSON, Valina, L. ,  DAWSON, Ted, M. ,  SNYDER, Solomon, H.

IPC: A61K31/165

CPC classification number: A61K31/47 ,  A61K31/165

Abstract: Inhibitors of poly(ADP-ribose) synthetase can be used to prevent neurotoxicity mediated through N-methyl-D-aspartate (NMDA) receptors. Poly(ADP-ribose) synthetase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.

Abstract translation: 聚（ADP-核糖）合成酶的抑制剂可用于预防由N-甲基-D-天冬氨酸（NMDA）受体介导的神经毒性。 聚（ADP-核糖）合成酶抑制剂可用于治疗血管性中风和神经变性疾病如阿尔茨海默氏病，帕金森病和亨廷顿舞蹈病。

公开(公告)号：WO2017161155A1

公开(公告)日：2017-09-21

申请号：PCT/US2017/022768

申请日：2017-03-16

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： SHIN, Joo-ho ,  JO, Areum ,  LEE, Yunjong ,  DAWSON, Ted, M. ,  DAWSON, Valina, L.

IPC: A61K31/045 ,  A61K31/202 ,  A61P25/16 ,  G01N33/50

Abstract: Methods of preventing or treating Parkinson's disease in subjects are described where drugs are administered to subjects in effective amounts to cause the farnesylation of PARIS and the enhanced expression of PGC-1 a in the brain. These methods alleviate the effects of Parkinson's disease in subjects, in part, by preventing the loss of dopamine neurons.

Abstract translation: 描述了在受试者中向受试者施用有效量的药物以引起PARIS的法尼基化和PGC-1α在脑中的增强表达的方法，描述了在受试者中预防或治疗帕金森氏病的方法。 这些方法减轻了帕金森氏病对受试者的影响，部分原因是通过防止多巴胺神经元的丢失。

公开(公告)号：WO2017112889A1

公开(公告)日：2017-06-29

申请号：PCT/US2016/068378

申请日：2016-12-22

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： LEE, Seulki ,  DAWSON, Ted, M. ,  KO, Han, Seok ,  DAWSON, Valina, L. ,  YUN, Seung, Pil ,  SWIERCZEWSKA, Magdalena

IPC: A61K38/26 ,  A61K38/38 ,  A61K47/48 ,  A61P25/28

CPC classification number: A61K38/26 ,  A61K38/38 ,  A61K47/60 ,  A61K47/68

Abstract: The present invention relates to compositions and methods for treating neurodegenerative conditions using GLP-1r agonists. In certain embodiments, long-acting GLP-1r agonists have neuroprotective and disease modifying effects on the central nervous system.

Abstract translation: 本发明涉及使用GLP-1r激动剂治疗神经变性疾病的组合物和方法。 在某些实施方案中，长效GLP-1r激动剂对中枢神经系统具有神经保护和疾病修饰作用。

公开(公告)号：WO1995014465A2

公开(公告)日：1995-06-01

申请号：PCT/US1994013457

申请日：1994-11-22

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  THE UNITED STATES OF AMERICA, NATIONAL INSTITUTE ON DRUG ABUSE ADDICTION RESEARCH CENTER

Inventor： THE JOHNS HOPKINS UNIVERSITY ,  THE UNITED STATES OF AMERICA, NATIONAL INSTITUTE ON DRUG ABUSE ADDICTION RESEARCH CENTER ,  DAWSON, Valina, L. ,  DAWSON, Ted, M. ,  UHL, George, R. ,  SNYDER, Solomon, H.

IPC: A61K31/22

CPC classification number: A61K31/70 ,  A61K31/00 ,  A61K31/18 ,  A61K31/195 ,  A61K31/22 ,  A61K31/415 ,  A61K31/54 ,  A61K38/13

Abstract: Methods are taught for amelioration of neurodegeneration which accompanies infection with an immunodeficiency virus. Agents are administered which reduce nitric oxide production by neurons (e.g. nitric oxide synthase inhibitors, calmodulin inhibitors, immunophilin binding drugs) or lower superoxide concentration (e.g. superoxide dismutase gene).

Abstract translation: 教导了改善伴随感染免疫缺陷病毒的神经变性的方法。 给予减少神经元（例如一氧化氮合酶抑制剂，钙调蛋白抑制剂，免疫亲和素结合药物）或较低超氧化物浓度（例如超氧化物歧化酶基因）产生一氧化氮的药剂。