公开(公告)号：EP1216053B1

公开(公告)日：2005-11-16

申请号：EP00966084.6

申请日：2000-09-27

申请人： SmithKline Beecham Biologicals s.a. ,  Saechsisches Serumwerk Dresden

发明人： D'HONDT, Erik, SmithKline Beecham Biologicals S.A. ,  HEHME, Norbert, Saechsisches Serumwerk Dresden

IPC分类号： A61K39/145 ,  A61P31/12

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/55505 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/16151 ,  C12N2760/16222 ,  C12N2760/16234 ,  C12N2760/16251

摘要： The invention provides a monovalent influenza vaccine comprising a low dose of egg-derived influenza virus antigen from an influenza virus strain that is associated with a pandemic outbreak or has the potential to be associated with a pandemic outbreak, in combination with an aluminium adjuvant. The invention also provides vaccine kits comprising a combination of a parenteral and a mucosal influenza vaccine, wherein the combined dose of antigen is no more than the conventional antigen dose. Also provided are methods for preparing the vaccines.

公开(公告)号：EP1529845A2

公开(公告)日：2005-05-11

申请号：EP05075216.1

申请日：1995-05-11

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： Gheysen, Dirk Richard

IPC分类号： C12N15/62 ,  C12N15/85 ,  C07K14/035 ,  C07K14/045 ,  C12N5/10 ,  A61K39/245

CPC分类号： A61K39/245 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/525 ,  C07K14/005 ,  C07K2319/00 ,  C12N2710/16122 ,  C12N2710/16134 ,  C12N2710/16622 ,  C12N2710/16634

摘要： A fusion protein comprising a portion of a glycoprotein of HCMV fused to a portion of a glycoprotein of HSV is described.

摘要翻译： 描述了融合蛋白，其包含与HSV的糖蛋白部分融合的HCMV的一部分糖蛋白。

公开(公告)号：EP0759995B1

公开(公告)日：2005-04-20

申请号：EP95919447.3

申请日：1995-05-11

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： GHEYSEN, Dirk R., SmithKline Beecham Bio. (S.A.)

IPC分类号： C12N15/62 ,  C12N15/85 ,  C07K14/035 ,  C07K14/045 ,  C12N5/10 ,  A61K39/245

CPC分类号： A61K39/245 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/525 ,  C07K14/005 ,  C07K2319/00 ,  C12N2710/16122 ,  C12N2710/16134 ,  C12N2710/16622 ,  C12N2710/16634

摘要： A fusion protein comprising a portion of a glycoprotein of HCMV fused to a portion of a glycoprotein of HSV is described.

公开(公告)号：EP1328541A2

公开(公告)日：2003-07-23

申请号：EP01987767.9

申请日：2001-10-16

申请人： SmithKline Beecham Biologicals s.a.

发明人： THONNARD, Joelle

IPC分类号： C07K14/285

CPC分类号： C07K14/285 ,  A61K39/00 ,  C07K16/1242

摘要： The invention provides nontypeable Haemophilus influenzae BASB207 polypeptides and polynucleotides encoding BASB207 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses, including vaccines against bacterial infections.

公开(公告)号：EP1254234A1

公开(公告)日：2002-11-06

申请号：EP01913816.3

申请日：2001-02-13

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： BERTHET, Francois-Xavier Jacques ,  DENOEL, Philippe ,  POOLMAN, Jan ,  THONNARD, Joelle

IPC分类号： C12N15/31 ,  C07K14/285 ,  A61K39/102

CPC分类号： C07K14/285 ,  A61K39/00

摘要： This invention relates to recombinant bacterial outer membrane proteins comprising one or more LB1(f) peptides from surface-exposed loop 3 of MOMP P5 of non-typeable H. influenzae. Polynucleotides encoding these recombinant proteins are also covered. The invention also relates to a method of isolating the recombinant proteins and a vaccine composition for use in the treatment of Haemophilus influenzae infection.

公开(公告)号：EP0959867B1

公开(公告)日：2002-10-02

申请号：EP98905344.2

申请日：1998-01-16

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： THILLY, Jacques, SmithKline Beecham Biol. S.A.

IPC分类号： A61J1/20

CPC分类号： A61J1/2096 ,  A61J1/1418 ,  A61J1/1425 ,  A61J1/201 ,  A61J2200/10 ,  Y10S604/905

摘要： A luer connector comprising a luer connectable to a syringe and which extends to a sharpened end capable of being driven through a puncturable vial closure to thereby puncture the closure; a luer support, mountable on a vial, and which initially supports the luer in a first position in which the sharpened end of the conduit is pointed toward the closure; a luer driver such that movement of the driver relative to the support causes the luer to be driven so that the sharpened end punctures the closure and enters the vial. The luer connector facilitates connection of a hypodermic syringe to the vial.

公开(公告)号：EP0941117B1

公开(公告)日：2002-08-28

申请号：EP97950137.6

申请日：1997-11-04

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： FLORENT, Patrick, SmithKline Beecham Biologicals ,  STEPHENNE, Jean, SmithKline Beecham Biologicals SA ,  VANDECASSERIE, Christian, SmithKline Beecham Biol.

IPC分类号： A61K39/10

CPC分类号： A61K39/08 ,  A61K39/0018 ,  A61K39/05 ,  A61K39/099 ,  A61K39/12 ,  A61K2039/70 ,  C12N2730/10134 ,  Y02A50/466

摘要： The invention provides a diphtheria, tetanus and pertussis vaccine comprising a low dose of each of diphtheria toxoid (D), tetanus toxoid (T), pertussis toxin (PT), filamentous haemagglutinin (FHA) and pertactin (69K). The vaccine maintains an ability to prevent pertussis while showing exceptionally low reactogenicity. Combination vaccines comprising additional antigens are also provided.

公开(公告)号：EP1223987A2

公开(公告)日：2002-07-24

申请号：EP00981226.4

申请日：2000-10-27

申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.),formerly SMITHKLINE BIOLOGICALS (S.A.)

发明人： LAFERRIERE,Craig,Antony,JosephSmithKline Beecham ,  POOLMAN, JanSmithKline Beecham Biologicals S.A. ,  SLAOUI,Moncef,MohamedSmithKline Beecham Biologic.

IPC分类号： A61K47/48 ,  A61K49/00

CPC分类号： G01N33/5088 ,  A61K39/092 ,  A61K47/646 ,  A61K2039/545 ,  A61K2039/6068 ,  G01N2400/10 ,  Y02A50/484

摘要： The present invention relates to the field of methods of testing a vaccine response in an animal model to obtain information on the response of humans to the same vaccinogen. The present invention provides a method of determining the dose response of a human to a polysaccharide conjugate vaccine comprising an immunogenic carrier protein and a bacterial polysaccharide, said method comprising the steps of administering to an infant animal a dose amount of said conjugated vaccine, and determining the immune response of the animal to the bacterial polysaccharide as a measure of the immune response of a human. Preferred, modes of administration of vaccine in the model, dose of vaccine tested, time between doses, time of serum harvesting, method of determination of immune response, and type (and age) of infant animal used are also all provided.

公开(公告)号：EP1216302A2

公开(公告)日：2002-06-26

申请号：EP00967819.4

申请日：2000-09-26

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： THONNARD, Joelle

IPC分类号： C12N15/31 ,  C12N15/63 ,  C07K14/195 ,  C07K16/12 ,  G01N33/53 ,  G01N33/68 ,  A61K39/02

CPC分类号： C07K14/212 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K2319/00

摘要： The invention provides BASB132 polypeptides and polynucleotides encoding BASB132 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.

公开(公告)号：EP1216301A2

公开(公告)日：2002-06-26

申请号：EP00958311.3

申请日：2000-07-27

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： THONNARD, JoelleSmithKline Beecham Biologic. s.a.

IPC分类号： C12N15/31 ,  C12N15/63 ,  C07K14/195 ,  C07K16/12 ,  G01N33/53 ,  G01N33/68 ,  A61K39/02

CPC分类号： C07K14/212 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K2319/00

摘要： The invention provides BASB123 polypeptides and polynucleotides encoding BASB123 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.