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公开(公告)号：EP1223987A2
公开(公告)日：2002-07-24
申请号：EP00981226.4
申请日：2000-10-27
发明人： LAFERRIERE,Craig,Antony,JosephSmithKline Beecham , POOLMAN, JanSmithKline Beecham Biologicals S.A. , SLAOUI,Moncef,MohamedSmithKline Beecham Biologic.
CPC分类号： G01N33/5088 , A61K39/092 , A61K47/646 , A61K2039/545 , A61K2039/6068 , G01N2400/10 , Y02A50/484
摘要： The present invention relates to the field of methods of testing a vaccine response in an animal model to obtain information on the response of humans to the same vaccinogen. The present invention provides a method of determining the dose response of a human to a polysaccharide conjugate vaccine comprising an immunogenic carrier protein and a bacterial polysaccharide, said method comprising the steps of administering to an infant animal a dose amount of said conjugated vaccine, and determining the immune response of the animal to the bacterial polysaccharide as a measure of the immune response of a human. Preferred, modes of administration of vaccine in the model, dose of vaccine tested, time between doses, time of serum harvesting, method of determination of immune response, and type (and age) of infant animal used are also all provided.
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公开(公告)号：EP1214054A1
公开(公告)日：2002-06-19
申请号：EP00967781.6
申请日：2000-09-22
发明人： FRIEDE, MartinSmithKline Beecham Biologicals s.a. , HENDERICKX, VeroniqueSmithKline Beecham Bio. s.a , HERMAND, PhilippeSmithKline Beecham Bio. s.a. , SLAOUI, Moncef MohamedSmithKline Beecham Bio. s.a , THOELEN, Stefan G.J.SmithKline BeechamBio. s.a.
IPC分类号： A61K9/00
CPC分类号： A61K39/39 , A61K9/0043 , A61K39/12 , A61K39/145 , A61K47/26 , A61K47/34 , A61K2039/5252 , A61K2039/543 , A61K2039/55511 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/58 , A61K2039/70 , C12N7/00 , C12N2760/16134 , C12N2760/16234
摘要： The invention relates to the use of a non-live influenza virus antigen preparation, particularly a split influenza virus preparation, in the manufacture of a vaccine formulation for a one-dose intranasal vaccination against influenza, wherein the one-dose vaccination meets international regulatory requirements for influenza vaccines. Further provided are methods for the production of the vaccine, and a pharmaceutical kit comprising an intranasal administration device and the one-dose vaccine.
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3.发明公开POLYNUCLEOTIDES AND POLYPEPTIDES BASB033 FROM NEISSERIA MENINGITIDIS AND THEIR USES 有权多核苷酸和多肽BASB033 AUS脑膜炎奈瑟氏菌及其用途
公开(公告)号：EP1112366A1
公开(公告)日：2001-07-04
申请号：EP99946160.1
申请日：1999-09-09
发明人： RUELLE, Jean-Louis
IPC分类号： C12N15/31 , C07K14/22 , C12N1/21 , C12Q1/68 , C07K16/12 , A61K39/095 , A61K31/70 , G01N33/68 , A61K39/40
CPC分类号： G01N33/56911 , A61K39/00 , A61K2039/51 , C07K14/22
摘要： The invention provides BASB033 polypeptides and polynucleotides encoding BASB033 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
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公开(公告)号：EP1083926A1
公开(公告)日：2001-03-21
申请号：EP99924543.4
申请日：1999-05-28
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.),formerly SMITHKLINE BIOLOGICALS (S.A.) , THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
IPC分类号： A61K39/02 , A61K39/00 , A61K39/102 , A61K38/00 , C07H21/04 , C07H21/02 , C07K16/00 , C12P21/06 , C12P21/04 , C12N1/20 , G01N33/53
CPC分类号： C07K16/1242 , A61K39/00 , C07K14/285 , C07K2319/00 , G01N33/56911
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公开(公告)号：EP0427462B1
公开(公告)日：1996-02-14
申请号：EP90311979.0
申请日：1990-11-01
发明人： Capiau, Carine, SmithKline Beecham Biologicals , Desmons, Pierre, SmithKline Beecham Biologicals
IPC分类号： C07K1/16
CPC分类号： C07K14/195 , A61K39/00
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6.发明公开EPITOPES OR MIMOTOPES DERIVED FROM THE C-EPSILON-3 OR C-EPSILON-4 DOMAINS OF IGE, ANTAGONISTS THEREOF, AND THEIR THERAPEUTIC USES 审中-公开的IgE表位和模拟表位从C EPSILON-3或衍生的C-EPSILON-4域WHICH antagoniste，以及它们的治疗用途
公开(公告)号：EP1155038A1
公开(公告)日：2001-11-21
申请号：EP00910690.7
申请日：2000-02-22
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.),formerly SMITHKLINE BIOLOGICALS (S.A.) , PEPTIDE THERAPEUTICS LIMITED
发明人： FRIEDE, MartinCorporate Intellectual Property , MASON, SeanPeptide Therapeutics Limited , TURNELL, William GordonPeptide Therapeutics Ltd. , VAN MECHELEN, Marcelle P.SmithKline Beecham , VINALS Y DE BASSOLS, Carlota,Smithkline Beecham
IPC分类号： C07K16/00 , C07K16/42 , A61K39/00 , A61K39/385 , A61K39/395 , G01N33/577 , G01N33/68 , A61P37/08
CPC分类号： C07K16/00 , A61K2039/505 , A61K2039/6068 , C07K2317/52
摘要： The present invention relates to the provision of novel medicaments for the treatment, prevention or amelioration of allergic disease. In particular, the novel medicaments are epitopes or mimotopes derived from the Cε3 or Cε4 domains of IgE. These novel regions may be the target for both passive and active immunoprophylaxis or immunotherapy. The invention further relates to methods for production of the medicaments, pharmaceutical compositions containing them and their use in medicine. Also forming an aspect of the present invention are ligands, especially monoclonal antibodies, which are capable of binding the IgE regions of the present invention, and their use in medicine as passive immunotherapy or immunoprophylaxis.
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7.发明公开
公开(公告)号：EP1196586A1
公开(公告)日：2002-04-17
申请号：EP00942127.2
申请日：2000-06-23
IPC分类号： C12N15/31 , C07K14/21 , A61K39/02 , A61K39/395 , A61K48/00 , G01N33/569 , C07K16/12
CPC分类号： C07K14/212 , A61K39/00 , A61K48/00
摘要： The invention provides BASB111 polypeptides and polynucleotides encoding BASB111 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
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公开(公告)号：EP1107787A2
公开(公告)日：2001-06-20
申请号：EP99944497.9
申请日：1999-08-24
发明人： DEMIL, Pascale,SmithKline Beecham , D'HONDT, Erik,SmithKline Beecham , VAN HOECKE, Christian,SmithKline Beecham
IPC分类号： A61K39/295 , A61K39/112 , C12P19/04 , A61P31/04 , A61P31/14
CPC分类号： C12P19/04 , A61K39/00 , A61K39/0275 , A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/70 , C07K14/255 , C12N2770/32411 , C12N2770/32434 , Y02A50/386 , Y02A50/464 , Y02A50/482 , Y02A50/484
摘要： A novel vaccine composition is provided which comprises: (a) a Salmonella typhi purified Vi polysaccharide; and (b) at least one other antigen wherein the vaccine components are stable and do not interfere with each other. The vaccine composition thus makes possible a single vaccination for protection against typhoid and other diseases such as hepatitis A, that travellers are prone to catch. Also described is a method of manufacturing Vi polysaccharide of S.typhi wherein the extraction and purification of the Vi polysaccharide is carried out in the absence of phenol.
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9.发明公开
公开(公告)号：EP1071784A1
公开(公告)日：2001-01-31
申请号：EP99923457.8
申请日：1999-04-20
发明人： RUELLE, Jean-Louis
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K2039/51
摘要： The invention provides BASB011 polypeptides and polynucleotides encoding BASB011 polypeptides from Moraxella m(Branhamella) catarrhalis and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
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10.发明公开IMMUNOGENIC POLYPEPTIDE DERIVED FROM MORAXELLA CATARRHALIS AND USES THEREOF 审中-公开免疫原性多肽OFF卡他莫拉菌及其用途
公开(公告)号：EP1204751A2
公开(公告)日：2002-05-15
申请号：EP00956337.0
申请日：2000-07-27
CPC分类号： C07K14/212 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K2319/00
摘要： The invention provides BASB127 polypeptides and polynucleotides encoding BASB127 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
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