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公开(公告)号：EP3259282A1
公开(公告)日：2017-12-27
申请号：EP16704641.6
申请日：2016-02-16
申请人： SANOFI
发明人： CORVEY, Carsten , STUMP, Heike , KRUIP, Jochen , CALANDRA, Bernhard , REY, Astrid , KARST, Nathalie , MOUREZ, Michael , FRAISSE, Laurent , ROTHE, Christine , ALLERSDORFER, Andrea , WIEDENMANN, Alexander , HINNER, Marlon , LUNDE, Bradley , JENSEN, Kristian , HÜLSMEYER, Martin
CPC分类号： C07K14/4703 , A61K38/00 , A61K38/005 , A61K38/012 , C07K14/47
摘要： The present disclosure provides hNGAL muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical applications, for example, to inhibit or reduce growth of P. aeruginosa. The present disclosure also concerns methods of making one or more pyoverdine- or pyochelin-binding muteins described herein as well as compositions comprising one or more of such muteins. The present disclosure further relates to nucleic acid molecules encoding such muteins and to methods for generation of such muteins and nucleic acid molecules. In addition, the application discloses therapeutic and/or diagnostic uses of these muteins as well as compositions comprising one or more of such muteins.
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2.发明公开COMPACT SENSOR FOR MEASURING TURBIDITY OR FLUORESCENCE IN A FLUID SAMPLE 审中-公开用于测量流体样品中浊度或荧光的紧凑型传感器
公开(公告)号：EP3218694A1
公开(公告)日：2017-09-20
申请号：EP15859681.7
申请日：2015-11-10
申请人： In-situ Inc.
摘要： Provided is a cleanable conductivity sensor and related methods having a distal sensing end in which active sensing elements are positioned and an outer fin specially configured to minimize unwanted interference without impacting the ability for automated cleaning of the distal sensing end. A rotatable wiper or brush may be periodically rotated over the distal sensing end, thereby removing unwanted biological build-up and avoiding fouling, thereby increasing the sensor deployment time without active intervention and maintenance.
摘要翻译： 提供了一种可清洁的电导率传感器和相关方法，其具有其中定位有有源传感元件的远端感测端和专门配置成最小化不想要的干扰而不影响远端感测端的自动清洁能力的外散热片。 可旋转的擦拭器或刷子可以在远端感测端周期性地旋转，从而消除不希望的生物积聚并避免结垢，由此增加传感器部署时间而无需主动干预和维护。
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3.发明公开IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE 审中-公开免疫调节性寡核苷酸（IRO）化合物调节TOLL样受体免疫反应
公开(公告)号：EP3213770A1
公开(公告)日：2017-09-06
申请号：EP17166068.1
申请日：2011-11-18
IPC分类号： A61K48/00 , C07H21/04 , C12N15/113
CPC分类号： C12N15/117 , A61K31/7115 , A61K31/7125 , A61K45/06 , C12N2310/17 , C12N2310/31 , C12N2310/317 , C12N2310/321 , C12N2310/3341 , C12N2310/336 , C12N2310/51 , C12N2310/52 , Y02A50/401 , Y02A50/411 , Y02A50/414 , A61K2300/00
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
摘要翻译： 本发明提供了作为TLR拮抗剂的新型免疫调节性寡核苷酸（IRO）及其使用方法。 这些IRO具有独特的序列，其响应于TLR配体或TLR激动剂而抑制或抑制TLR介导的信号传导。 该方法可用于预防和治疗癌症，自身免疫病症，气道炎症，炎性病症，感染性疾病，皮肤病，变态反应，哮喘或由病原体引起的疾病。
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4.发明公开PURIFIED MESENCHYMAL STEM CELL COMPOSITIONS AND METHODS OF PURIFYING MESENCHYMAL STEM CELL COMPOSITIONS 审中-公开从骨髓间充质干细胞和方法从骨髓间充质干细胞清洁组合物清洁成分
公开(公告)号：EP3124601A1
公开(公告)日：2017-02-01
申请号：EP16189444.9
申请日：2009-08-14
发明人： Danilkovich, Alla , Newman, Robert, E. , Tom, Samson , Ton, Christopher , Wang, Zhanling , Young, Randal
CPC分类号： A61K35/28 , A61K2035/124 , C12N5/0663
摘要： One or more purified mesenchymal stem cell pharmaceutical compositions and methods of manufacture utilizing centrifugal filtration are disclosed. Threshold limits for intravenous administration of mesenchymal stem cell pharmaceutical compositions comprising residual animal products are also disclosed.
摘要翻译： 一种或多种纯化的间充质干细胞的药物组合物和利用离心过滤的制造方法是游离缺失盘。 因此，对于间充质干细胞的药物组合物包含残余动物产品的静脉内给药的阈值限制是游离缺失盘。
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5.发明公开
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公开(公告)号：EP2814840B1
公开(公告)日：2019-11-13
申请号：EP12868427.1
申请日：2012-07-11
发明人： SCHELLENBERGER, Volker , CHANG, Pei-yun , VARFAJ, Fatbardha , DING, Sheng , SILVERMAN, Joshua , WANG, Chia-wei , SPINK, Benjamin , STEMMER, Willem, P. , GEETHING, Nathan , KULMAN, John , LIU, Tongyao , TOBY, Garabet, G. , JIANG, Haiyan , PETERS, Robert , WANG, Deping , MEI, Baisong
IPC分类号： C07K14/755 , A61K38/37 , A61K38/00
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公开(公告)号：EP3558341A1
公开(公告)日：2019-10-30
申请号：EP17832071.9
申请日：2017-12-22
申请人： Sanofi
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公开(公告)号：EP3235516B1
公开(公告)日：2019-06-26
申请号：EP16166637.5
申请日：2016-04-22
发明人： KÜGLER, Sebastian
IPC分类号： C12N15/86 , A61K48/00 , C07K14/475
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公开(公告)号：EP3427723A1
公开(公告)日：2019-01-16
申请号：EP18171522.8
申请日：2013-03-25
申请人： BioNTech RNA Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , HAAS, Heinrich , KREITER, Sebastian , DIKEN, Mustafa , FRITZ, Daniel , MENG, Martin , KRANZ, Lena Mareen , REUTER, Kerstin
摘要： The present invention is in the field of immunotherapy, in particular tumor immunotherapy. The present invention provides pharmaceutical formulations for delivering RNA to antigen presenting cells such as dendrite cells (DCs) in the spleen after systemic administration. In particular, the formulations described herein enable to induce an immune response after systemic administration of antigen-coding RNA.
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公开(公告)号：EP3389703A1
公开(公告)日：2018-10-24
申请号：EP16820198.6
申请日：2016-12-14
IPC分类号： A61K39/02
CPC分类号： A61K39/0208 , A61K39/105 , A61K2039/55544 , A61K2039/70 , A61P1/04 , A61P35/00 , C07K14/205 , G01N33/56922
摘要： The present invention relates to immunogenic compositions and their use in the prevention or treatment of diseases or disorders caused by or associated with Helicobacter pylori, in particular H. pylori infection and gastroduodenal disorders caused by H. pylori. The present invention further relates to methods of detecting H. pylori infection in a subject.
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