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    PROCEDE POUR L INDUCTION MAITRISEE DE MUTATIONS SOMATIQUES E T SON APLLICATION EN PROTEOMIQUE
    1.
    发明授权
    PROCEDE POUR L INDUCTION MAITRISEE DE MUTATIONS SOMATIQUES E T SON APLLICATION EN PROTEOMIQUE 有权
    法体细胞突变控制的感应及其用途蛋白质组学

    公开(公告)号：EP1463816B1

    公开(公告)日：2007-08-29

    申请号：EP02804929.4

    申请日：2002-12-17

    申请人： Mixis France S.A.

    发明人： REYNAUD, Claude-Agnès ,  WEILL, Jean-Claude

    IPC分类号： C12N15/10 ,  C12N15/01 ,  C07K14/62 ,  C12N15/90

    CPC分类号： C12N15/102 ,  C12N15/01

    摘要： The invention concerns a method for inducing somatic mutations in vitro or ex vivo, comprising (1): adding to the cells to be mutated, in culture conditions and in a medium suited to said cells, of at least a combination of anti-IgM and anti-CD19 and/or anti-DC21 antibodies, while (2) said anti-IgM antibodies are biotinylated and are subjected to specific aggregation by streptavidin coupled with a support. Advantageously, the mutations are controlled and/or adjusted by inhibiting and reactivating and/or stimulating DNA polymerase pol iota. The invention is in particular applicable to rapid and controlled induction of mutations on the BL2 Burkitt's lymphoma.

    GENERATION OF RECOMBINANT GENES IN BACTERIOPHAGES
    4.
    发明公开
    GENERATION OF RECOMBINANT GENES IN BACTERIOPHAGES 审中-公开
    产生重组基因在噬菌体

    公开(公告)号：EP1763579A1

    公开(公告)日：2007-03-21

    申请号：EP05758007.8

    申请日：2005-07-06

    申请人： Mixis France S.A.

    发明人： LUQUE, Alejandro ,  STROBEL, Heike ,  MARTINSOHN, Jann, Thorsten ,  PETIT, Marie-Agnès ,  RADMAN, Miroslav

    IPC分类号： C12N15/10 ,  C12N15/73

    CPC分类号： C12N15/73

    摘要： The present invention relates to in vivo methods for generating and detecting recombinant DNA sequences in bacteriophages or plasmids containing bacteriophage sequences, methods for generating hybrid genes and hybrid proteins encoded by these hybrid genes by the use of bacteriophages and plasmids containing bacteriophage sequences, bacteriophages and plasmids that can be used in these methods, and kits comprising appropriate bacterial host cells and bacteriophages or plasmids. DNA sequences for which these methods are relevant include protein-encoding and non-coding sequences.

    REDUCTION OF SPONTANEOUS MUTATION RATES IN CELLS
    8.
    发明公开
    REDUCTION OF SPONTANEOUS MUTATION RATES IN CELLS 审中-公开
    减少其发病率自发突变细胞

    公开(公告)号：EP1718758A1

    公开(公告)日：2006-11-08

    申请号：EP05707650.7

    申请日：2005-02-26

    申请人： Mixis France S.A.

    发明人： STROBEL, Heike ,  SCHOENFELD, Wolfgang

    IPC分类号： C12Q1/02 ,  C12N1/20 ,  C12N15/63 ,  C12N15/09

    CPC分类号： C12N15/102

    摘要： The present invention relates to processes for reducing the spontaneous mutation frequencies in cells or organisms and for producing such cells and organisms, to cells and/or organisms with reduced spontaneous mutation frequencies and to processes for the generation of expression systems for proteins, for the production of proteins and for the production of fermentation products by using cells with reduced spontaneous mutation frequencies.