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公开(公告)号：EP2825666B1
公开(公告)日：2018-12-05
申请号：EP13710334.7
申请日：2013-03-08
申请人： Siemens Healthcare GmbH , Siemens Healthcare Diagnostics Holding GmbH , Siemens Healthcare Diagnostics Inc. , Siemens Healthcare Diagnostics Products GmbH
发明人： KAPPEL, Andreas , KELLER, Andreas , STÄHLER, Cord Friedrich , WRIGHT, Ian , ANDERSON-MAUSER, Linda Marie , BEDZYK, William , SCHWARZ, Herbert , WICKE, Michaela
IPC分类号： C12Q1/6804
CPC分类号： C12Q1/6804 , C12Q2537/101 , C12Q2537/1373 , C12Q2545/107 , C12Q2537/125 , C12Q2537/143 , C12Q2563/131
摘要： The invention relates to a method of detecting nucleic acid molecules by immunoassay detection. Detection of a specific nucleic acid molecule of interest is achieved by using a nucleic acid probe in solution which hybridizes in solution to the nucleic acid molecule of interest. Immunoassay detection is achieved by using anantibody specific for the hybrid formed by hybridization of the nucleic acid probe to the nucleic acid molecule of interest.
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2.发明公开
公开(公告)号：EP2825666A1
公开(公告)日：2015-01-21
申请号：EP13710334.7
申请日：2013-03-08
申请人： Siemens Aktiengesellschaft , Siemens Healthcare Diagnostics Holding GmbH , Siemens Healthcare Diagnostics Inc. , Siemens Healthcare Diagnostics Products GmbH
发明人： KAPPEL, Andreas , KELLER, Andreas , STÄHLER, Cord Friedrich , WRIGHT, Ian , ANDERSON-MAUSER, Linda Marie , BEDZYK, William , SCHWARZ, Herbert , WICKE, Michaela
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6804 , C12Q2537/101 , C12Q2537/1373 , C12Q2545/107 , C12Q2537/125 , C12Q2537/143 , C12Q2563/131
摘要： The invention relates to a method of detecting nucleic acid molecules by immunoassay detection. Detection of a specific nucleic acid molecule of interest is achieved by using a nucleic acid probe in solution which hybridizes in solution to the nucleic acid molecule of interest. Immunoassay detection is achieved by using anantibody specific for the hybrid formed by hybridization of the nucleic acid probe to the nucleic acid molecule of interest.
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3.发明公开Immunoassay for detection of specific nucleic acid sequences such as miRNAs 有权免疫测定zur Erkennung von miRNA
公开(公告)号：EP2639312A1
公开(公告)日：2013-09-18
申请号：EP12159196.0
申请日：2012-03-13
申请人： Siemens Aktiengesellschaft , Siemens Healthcare Diagnostics Holding GmbH , Siemens Healthcare Diagnostics Inc. , Siemens Healthcare Diagnostics Products GmbH
发明人： Kappel, Andreas , Keller, Andreas , Stähler, Cord Friedrich , Wright, Ian , Anderson-Mauser, Linda Marie , Bedzyk, William , Schwarz, Herbert , Wicke, Michaela
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6804 , C12Q2537/101 , C12Q2537/1373 , C12Q2545/107 , C12Q2537/125 , C12Q2537/143 , C12Q2563/131
摘要： The invention relates to a method of detecting nucleic acid molecules by immunoassay detection. Detection of a specific nucleic acid molecule of interest is achieved by using a nucleic acid probe in solution which hybridizes in solution to the nucleic acid molecule of interest. Immunoassay detection is achieved by using anantibody specific for the hybrid formed by hybridization of the nucleic acid probe to the nucleic acid molecule of interest.
摘要翻译： 本发明涉及通过免疫测定检测检测核酸分子的方法。 通过使用溶液中的核酸探针在感兴趣的核酸分子的溶液中进行检测来实现感兴趣的特定核酸分子的检测。 通过使用对通过核酸探针与感兴趣的核酸分子杂交形成的杂合体特异性的抗体来实现免疫测定检测。
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公开(公告)号：EP2639312B1
公开(公告)日：2017-08-02
申请号：EP12159196.0
申请日：2012-03-13
申请人： Siemens Healthcare GmbH , Siemens Healthcare Diagnostics Holding GmbH , Siemens Healthcare Diagnostics Inc. , Siemens Healthcare Diagnostics Products GmbH
发明人： Kappel, Andreas , Keller, Andreas , Stähler, Cord Friedrich , Wright, Ian , Anderson-Mauser, Linda Marie , Bedzyk, William , Schwarz, Herbert , Wicke, Michaela
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6804 , C12Q2537/101 , C12Q2537/1373 , C12Q2545/107 , C12Q2537/125 , C12Q2537/143 , C12Q2563/131
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5.发明公开
公开(公告)号：EP3153856A1
公开(公告)日：2017-04-12
申请号：EP15188536.5
申请日：2015-10-06
发明人： Prechtl, Gottfried , Jones, Val
IPC分类号： G01N33/49 , G01N15/05 , G01N33/569 , G01N33/80 , G01N15/00
CPC分类号： G01N33/56966 , G01N15/1459 , G01N33/80 , G01N2015/0084 , G01N2015/1006 , G01N2015/1402 , G01N2015/1488 , G01N2800/224 , G01N2800/226
摘要： Die Erfindung betrifft ein Verfahren zur Bestimmung der Konzentration von retikulierten Thrombozyten in einer Thrombozyten enthaltenden Probe (4) eines Biofluids, insbesondere in einer Blutprobe, wobei der Probe (4) des Biofluids ein für Nukleinsäure selektiver Farbstoff zugeführt wird, wobei nach der Anfärbung in der Probe (4) im Absorptionsbereich des Farbstoffes eine Vielzahl von optischen, partikelbedingten Messwerten jeweils als Tupel aus Brechungsindex und Absorptionsgrad bestimmt wird, wobei Messwerte mit einem Absorptionsgrad innerhalb eines Teilbereiches (6) aller gemessenen Werte des Absorptionsgrades und mit einem Brechungsindex innerhalb eines Teilbereiches (7) aller gemessenen Werte des Brechungsindexes selektiert werden, und wobei die Anzahl der selektierten Messwerte zur Bestimmung der Konzentration der retikulierten Thrombozyten herangezogen wird.
摘要翻译： 本发明涉及一种用于确定包含在生物流体的血小板样品（4）在网织血小板的浓度，尤其是血液样品，其中所述样品（4）的生物流体a的是用于核酸选择性染料供给，其特征在于，染色后的 样品（4）在染料的吸收范围的各种在每种情况下如折射率和吸收系数的元组光学，基于颗粒的测定值的判定，其特征在于，具有部分区域内的吸收度的测量值（6）的吸收系数的所有测量值，并具有一个局部区域内的折射率（7 ）的折射率的所有测量值都被选择，且其中用于选择的测量值的，用于确定网织血小板的浓度的数量。
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6.发明公开METHOD AND APPARATUS FOR LOW-VOLUME ANALYZER WITH FIXED AND VARIABLE INDEXING 审中-公开方法和装置与固定和可变分度低容量分析单元
公开(公告)号：EP2427777A1
公开(公告)日：2012-03-14
申请号：EP10772637.4
申请日：2010-05-03
IPC分类号： G01N35/00
CPC分类号： G01N35/0092 , G01N35/025
摘要： A sample analyzer with fixed and variable indexing that is structured and arranged to align reaction vessels, e.g., cuvettes, at a pre-determined, fixed point while maintaining a positional sequence using variable indexing. Variable indexing allows cuvettes to be presented to multiple, fixed point resources at multiple occasions in a systematic progression in a highly efficient manner. The presentation of cuvettes to multiple, fixed point resources at multiple times is superior to existing indexing.
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公开(公告)号：EP2427777A4
公开(公告)日：2018-01-03
申请号：EP10772637
申请日：2010-05-03
发明人： EVERS TIMOTHY P , MICHELS THORSTEN , PUFAHL HOLGER
CPC分类号： G01N35/0092 , G01N35/025
摘要： A sample analyzer with fixed and variable indexing that is structured and arranged to align reaction vessels, e.g., cuvettes, at a pre-determined, fixed point while maintaining a positional sequence using variable indexing. Variable indexing allows cuvettes to be presented to multiple, fixed point resources at multiple occasions in a systematic progression in a highly efficient manner. The presentation of cuvettes to multiple, fixed point resources at multiple times is superior to existing indexing.
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公开(公告)号：EP4416505A1
公开(公告)日：2024-08-21
申请号：EP22881903.3
申请日：2022-09-23
发明人： ZHAO, Zhijian , ZHENG, Yi Feng , RYBIN, Andrew , FREEMAN, James
CPC分类号： C07K16/44 , G01N33/743 , G01N33/82 , G01N33/54326
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公开(公告)号：EP4379374A3
公开(公告)日：2024-08-21
申请号：EP24164803.9
申请日：2019-08-19
发明人： PUDDUCK, Christian
IPC分类号： G01N27/06 , G01N27/27 , G01N27/327 , G01N27/403 , G01N33/49
CPC分类号： G01N33/4925 , G01N2021/314420130101 , G01N21/314 , G01N27/26
摘要： Improved analyte detection system within a blood gas analyzer, the improved system comprising and/or consisting of at least one CO-oximetry system that is formed as an integrated, unitary structure(s) with an electrochemical sensor module, and methods of use related thereto.
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10.发明公开
公开(公告)号：EP4406614A2
公开(公告)日：2024-07-31
申请号：EP24175691.5
申请日：2019-10-25
发明人： WEI, Tie , TENG, Zhu , DRINAN, Martin , LI, Jie
IPC分类号： A61P37/06
CPC分类号： A61P37/06 , G01N33/9493 , C07D498/18
摘要： Compositions comprising binding competitors that can be used in assays for macrophilin-binding pharmaceuticals in samples are disclosed, as well as kits containing same and methods of use thereof.
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