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公开(公告)号：EP3409287A1
公开(公告)日：2018-12-05
申请号：EP18171803.2
申请日：2011-09-29
发明人： SATPAEV, Daulet , MORRISON, Robert Kendall , MORRISON, Karen Jane Meyrick , GUDAS, Jean , JAKOBOVITS, Aya , TORGOV, Michael , AN, Zili
CPC分类号： A61K47/48569 , A61K47/48384 , A61K47/48415 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/1001 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： The present disclosure relates to antibody drug conjugates (ADC's) with auristatin E that binds to 191P4D12 protein and variants thereof. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in some cancers. The ADC's of provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：EP2621526A1
公开(公告)日：2013-08-07
申请号：EP11831345.1
申请日：2011-09-29
发明人： SATPAEV, Daulet , MORRISON, Robert, Kendall , MORRISON, Karen Jane, Meyrick , GUDAS, Jean , JAKOBOVITS, Aya , TORGOV, Michael , AN, Zili
IPC分类号： A61K39/00 , A61K39/395 , C07K1/00
CPC分类号： A61K47/6851 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/1001 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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3.发明公开
公开(公告)号：EP2403524A1
公开(公告)日：2012-01-11
申请号：EP10756560.8
申请日：2010-03-05
发明人： GUDAS, Jean , JAKOBOVITS, Aya , AN, Zili , MORRISON, Robert, Kendall , MORRISON, Karen, Jane Meyrick , JIA, Xiao-Chi , BENJAMIN, Dennis , MOSER, Ruth , SENTER, Peter
CPC分类号： C07K16/30 , A61K45/06 , A61K47/6803 , A61K47/6851 , A61K47/6863 , A61K2039/505 , C07K16/3046
摘要： Antibody drug conjugates (ADC's) that bind to 24P4C12 protein and variants thereof are described herein. 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：EP2621526B1
公开(公告)日：2018-06-06
申请号：EP11831345.1
申请日：2011-09-29
发明人： SATPAEV, Daulet , MORRISON, Robert, Kendall , MORRISON, Karen Jane, Meyrick , GUDAS, Jean , JAKOBOVITS, Aya , TORGOV, Michael , AN, Zili
CPC分类号： A61K47/48569 , A61K47/48384 , A61K47/48415 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/1001 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：EP3395361A1
公开(公告)日：2018-10-31
申请号：EP18162821.5
申请日：2011-02-08
申请人： Agensys, Inc.
CPC分类号： A61K47/6811 , A61K39/39558 , A61K47/6849 , A61K47/6861 , A61K2039/505 , C07K16/28 , C07K16/3038 , C07K2317/21 , C07K2317/56 , C07K2317/92
摘要： The present invention provides antibody drug conjugates or antigen binding fragment thereof that bind to 161P2F10B protein, wherein the antibody or antigen binding fragment thereof is conjugated to one or more units of monomethyl auristatin F (MMAF), each unit being conjugated via a linker. Provided are also antibody drug conjugates for use as a medicament, and pharmaceutical compositions that comprise the antibody drug conjugates in a human unit dose form. Further provided are antibody drug conjugates or the pharmaceutical compositions of the invention for use in treating cancer/tumor or inhibiting cancer/tumor growth in a subject.
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6.发明公开
公开(公告)号：EP2533804A1
公开(公告)日：2012-12-19
申请号：EP11740529.0
申请日：2011-02-08
申请人： Agensys, Inc.
IPC分类号： A61K39/00
CPC分类号： A61K47/48607 , A61K39/39558 , A61K47/6811 , A61K47/6849 , A61K47/6861 , A61K2039/505 , C07K16/28 , C07K16/3038 , C07K2317/21 , C07K2317/56 , C07K2317/92
摘要： Antibody drug conjugates (ADC's) that bind to 161P2F10B protein are described herein. 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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7.发明授权NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 184P1E2 USEFUL IN TREATMENT AND DETECTION OF CANCER 有权NUCLEIC与此相对应，184P1E2呼吁处理和检测步骤癌蛋白飞度
公开(公告)号：EP1573022B1
公开(公告)日：2011-06-08
申请号：EP02731360.0
申请日：2002-04-09
申请人： Agensys, Inc.
发明人： CHALITTA-EID, Pia, M. , RAITANO, Arthur, B. , FARIS, Mary , HUBERT, Rene, S. , MORRISON, Karen , MORRISON, Robert, Kendall , GE, Wangmao , JAKOBOVITS, Aya
CPC分类号： C07K14/47 , A61K38/00 , C12N9/78 , Y10T436/25
摘要： A novel gene (designated 184P1E2) and its encoded protein, and variants thereof, are described wherein 184P1E2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 184P1E2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 184P1E2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 184P1E2 can be used in active or passive immunization.
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8.发明公开
公开(公告)号：EP1863848A2
公开(公告)日：2007-12-12
申请号：EP06749164.7
申请日：2006-03-31
申请人： Agensys, Inc.
发明人： JAKOBOVITS, Aya , KANNER, Steven, B. , CHALLITA-EID, Pia, M. , PEREZ-VILLAR, Juan, J. , SATPAEV, Daulet , RAITANO, Arthur, B. , MORRISON, Robert, Kendall , MORRISON, Karen, Jane, Meyrick , JIA, Xiao-chi , GUDAS, Jean
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/73
摘要： Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
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9.发明公开ANTIBODIES AND MOLECULES DERIVED THEREFROM THAT BIND TO STEAP-1 PROTEINS 有权抗体和它们的衍生物分子是否涉及STEAP-1蛋白结合
公开(公告)号：EP1742966A2
公开(公告)日：2007-01-17
申请号：EP04750565.6
申请日：2004-04-22
申请人： Agensys, Inc.
发明人： JAKOBOVITS, Aya , ETESSAMI, Soudabeh , CHALLITA-EID, Pia, M. , PEREZ-VILLAR, Juan, J. , MORRISON, Karen, J. , JIA, Xiao-Chi , FARIS, Mary , GUDAS, Jean , RAITANO, Arthur, B.
IPC分类号： C07K16/00
CPC分类号： C07K16/40 , A61K39/39533 , A61K45/06 , A61K47/48607 , A61K47/6861 , A61K51/106 , A61K51/1075 , A61K2039/505 , C07H21/04 , C07K16/3069 , C07K2317/24 , C07K2317/565 , G01N33/6887 , A61K2300/00
摘要： Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.
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10.发明公开NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 282P1G3 USEFUL IN TREATMENT AND DETECTION OF CANCER 审中-公开NUCLEIC并用于治疗与名称282P1G3相关蛋白健身与治疗学检测
公开(公告)号：EP1576130A2
公开(公告)日：2005-09-21
申请号：EP03788229.7
申请日：2003-05-09
申请人： Agensys, Inc.
IPC分类号： C12N1/00
CPC分类号： C12N5/0693 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K47/6851 , A61K2039/505 , C07K14/435 , C07K14/47 , C07K2319/00 , G01N33/57484 , Y02A50/466
摘要： A novel gene 282P1G3 and its encoded protein, and variants thereof, are described wherein 282P1G3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 282P1G3 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 282P1G3 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 282P1G3 can be used in active or passive immunization.
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