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公开(公告)号：EP0368349B1
公开(公告)日：1993-09-15
申请号：EP89120904.1
申请日：1989-11-10
IPC分类号： C07H15/244 , A61K31/70 , C12P19/56 , C12N1/20
CPC分类号： C07H15/244 , C12P19/56
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公开(公告)号：EP0368349A3
公开(公告)日：1991-04-24
申请号：EP89120904.1
申请日：1989-11-10
IPC分类号： C07H15/244 , A61K31/70 , C12P19/56 , C12N1/20
CPC分类号： C07H15/244 , C12P19/56
摘要： Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof (I). These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.
wherein the serine is D-serine; R¹ and R² are independently H or C₁₋₆ alkyl; and R³ is H or β-D-xylosyl; or a pharmaceutically acceptable salt thereof.-
公开(公告)号：EP0407939A1
公开(公告)日：1991-01-16
申请号：EP90113085.6
申请日：1990-07-09
CPC分类号： C12P1/06 , C12R1/01 , Y10S435/822
摘要： Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A1, A 2 , A3, D 1 , D 2 and D 3 , by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.
摘要翻译： 公开了通过发酵新型微生物副杆菌ATCC-53884的BU-3889V生产菌株生产抗病毒抗生素复合物BU-3889V及其生物活性成分A1，A2，A3，D1，D2和D3。 通过使用离子交换色谱技术分离复合物BU-3889V，并将其分离。 生物活性成分的特征在于其物理化学性质。 已经发现这些产品有效地抑制包括单纯疱疹病毒，人类免疫缺陷病毒（HIV）和流感病毒在内的病毒。
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公开(公告)号：EP0277621A1
公开(公告)日：1988-08-10
申请号：EP88101410.4
申请日：1988-02-01
发明人： Oki, Toshikazu , Saitoh, Kyoichiro , Tomatsu, Kozo , Tomita, Koji , Konishi, Masataka , Miyaki, Takeo , Tsunakawa, Mitsuaki , Nishio, Maki
IPC分类号： C07H15/244 , A61K31/70 , C12P19/56
CPC分类号： C12R1/03 , C07H15/244 , C12P19/56
摘要： Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.
摘要翻译： 本文命名为BU-3608，BU-3608B和BU-3608C的新型抗生素通过发行Actinomadura hibisca菌株P157-2，ATCC 53557和菌株Q278-4，ATCC 53646产生。抗生素具有 抗真菌和抗病毒活性。
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公开(公告)号：EP0277621B1
公开(公告)日：1992-02-05
申请号：EP88101410.4
申请日：1988-02-01
发明人： Oki, Toshikazu , Saitoh, Kyoichiro , Tomatsu, Kozo , Tomita, Koji , Konishi, Masataka , Miyaki, Takeo , Tsunakawa, Mitsuaki , Nishio, Maki
IPC分类号： C07H15/244 , A61K31/70 , C12P19/56
CPC分类号： C12R1/03 , C07H15/244 , C12P19/56
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公开(公告)号：EP0345735A2
公开(公告)日：1989-12-13
申请号：EP89110234.5
申请日：1989-06-06
发明人： Nishio, Maki , Sawada, Yosuke , Miyaki, Takeo , Oki, Toshikazu
IPC分类号： C07H15/244 , C12P19/56 , A61K31/70 , C12R1/03
CPC分类号： C12R1/03 , C07H15/244 , C12P19/56 , Y10S435/825
摘要： Disclosed herein are antibiotic BU-3608 D and E isolated from Actinomadura hibisca. These compounds are active antifungal agents.
摘要翻译： 本文公开了从放线菌（Actinomadura hibisca）分离的抗生素BU-3608D和E（I）。 这些化合物是活性抗真菌剂。
其中R 1是H或甲基 -
公开(公告)号：EP0484856A3
公开(公告)日：1992-07-01
申请号：EP91118770.6
申请日：1991-11-04
IPC分类号： C07D491/044 , C12P17/18 , A61K31/445
CPC分类号： C07D491/04 , C12P17/18 , C12R1/29
摘要： The novel antitumor antibiotic of formula (I) designated herein as dynemicin C is produced by fermentation of Micromonospora chersina M956-1 mutant F1085 (ATCC-55077). Dynemicin C and its triacetate derivative possess antibacterial and antifungal activity and also inhibit the growth of mammalian tumors.
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公开(公告)号：EP0432697A2
公开(公告)日：1991-06-19
申请号：EP90123699.2
申请日：1990-12-10
IPC分类号： C07D405/06 , C12P17/16 , C12N1/20
CPC分类号： C07D405/06
摘要： A novel antibiotic designated BU-4146T is produced by fermentation of Streptomyces amphibiosporus strain R310-104 (ATCC-53964). The antibiotic possesses both antifungal and antitumor activity.
摘要翻译： 命名为BU-4146T的新型抗生素通过发酵链霉菌（Streptomyces amphibiosporus）菌株R310-104（ATCC-53964）产生。 抗生素具有抗真菌和抗肿瘤活性。
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公开(公告)号：EP0345735A3
公开(公告)日：1991-04-24
申请号：EP89110234.5
申请日：1989-06-06
发明人： Nishio, Maki , Sawada, Yosuke , Miyaki, Takeo , Oki, Toshikazu
IPC分类号： C07H15/244 , C12P19/56 , A61K31/70 , C12R1/03
CPC分类号： C12R1/03 , C07H15/244 , C12P19/56 , Y10S435/825
摘要： Disclosed herein are antibiotic BU-3608 D and E isolated from Actinomadura hibisca. These compounds are active antifungal agents.
摘要翻译： 本文公开了从马杜拉马杜拉放线菌（Actinomadura hibisca）分离的抗生素BU-3608D和E. 这些化合物是有效的抗真菌剂。
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公开(公告)号：EP0368349A2
公开(公告)日：1990-05-16
申请号：EP89120904.1
申请日：1989-11-10
IPC分类号： C07H15/244 , A61K31/70 , C12P19/56 , C12N1/20
CPC分类号： C07H15/244 , C12P19/56
摘要： Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof (I). These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.
wherein the serine is D-serine; R¹ and R² are independently H or C₁₋₆ alkyl; and R³ is H or β-D-xylosyl; or a pharmaceutically acceptable salt thereof.摘要翻译： 公开了抗生素BU-3608FA-1和FA-2及其烷基衍生物（I）。 这些化合物可用作抗真菌剂。 BU-3608 FA-1和FA-2由含有D-丝氨酸源的培养基中的放线菌（Ininomadura hibisca）生产。
，其中丝氨酸是D-丝氨酸; R 1和R 2独立地是H或C 1-6烷基; 且R 3为H或β-D-木糖基; 或其药学上可接受的盐。
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