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公开(公告)号：EP3604304A1
公开(公告)日：2020-02-05
申请号：EP18770572.8
申请日：2018-03-23
申请人： Daegu-Gyeongbuk Medical Innovation Foundation , Korea Research Institute of Bioscience and Biotechnology , Daegu Gyeongbuk Institute of Science and Technology
发明人： CHOI, Hwan Geun , KO, Eunhwa , CHO, Joong-heui , SON, Jung Beom , KO, Yi Kyung , PARK, Jin-Hee , KIM, So Young , KANG, Seock Yong , LEE, Seungyeon , RYU, Hee Yoon , KIM, Nam Doo , KIM, Sang Bum , LEE, Sun-Hwa , KIM, Dayea , LEE, Sun Joo , CHO, Sungchan , LEE, Kyu-Sun , YU, Kweon , CHOI, Miri , KOO, Ja Wook , HOE, Hyang-Sook
IPC分类号： C07D471/04 , A61K31/437 , A61K31/5377 , A23L33/10
摘要： The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.
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公开(公告)号：EP4159726A1
公开(公告)日：2023-04-05
申请号：EP21813774.3
申请日：2021-05-25
发明人： SONG, Minsoo , PARK, Ga Young , KO, Eun Bi , KANG, Jihee , IM, Chun Young , BAE, Seri , KIM, Soong-Hyun , PARK, Yoojin , LEE, Eunhye , CHOI, Yujeong , KIM, Sang Bum , KWON, Oh-Bin , SHIN, Chan Young , KWON, Kyoung Ja , PAUDEL, Suresh , JEON, Se Jin , CHO, Kyu Suk
IPC分类号： C07D401/06 , A61K31/454 , A61K31/496 , A61P25/00 , A61P25/18 , C07D403/06 , C07D401/14 , A23L33/10
摘要： The present invention relates to a 5-membered heteroaryl derivative containing an N, and a pharmaceutical composition for use in preventing or treating mental disorders, containing same as an active ingredient, wherein the derivative is excellent in the triple reuptake inhibitory effect of serotonin, norepinephrine, and dopamine, and thus can be useful in the treatment of mental disorders.
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公开(公告)号：EP4105217A1
公开(公告)日：2022-12-21
申请号：EP21761078.1
申请日：2021-02-26
发明人： LEE, Doohyun , LEE, Seungyeon , HAN, Ye Ri , IM, Chun Young , KIM, So Young , KIM, Nam Hui , CHOI, Hwan Geun , KO, Eunhwa , MOON, Heegyum , LEE, Sun Joo , KIM, Sang Bum , KIM, Hyo-Ji , LEE, Sion , AHN, Sung-Min , CHANG, Kiho , LEE, Eunkyu , KWON, Hyun Jin , JEONG, Myeong-Sook , KIM, Ji Young
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/496 , A61P35/00 , A23L33/10
摘要： The present invention relates to a 3-((8-((1H-pyrazol-4-yl)amino)imidazo[1,2-a]pyridin-3-yl)ethynyl)-N-phenylbenzamide derivative, a method for preparing the same, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating cancer. The derivative can significantly inhibit the proliferation of cancer cells by inhibiting kinases, particularly Bcr-Abl kinase or Bcr-Abl (T315I) kinase. Therefore, the derivative can be effectively used as a pharmaceutical composition for the prevention or treatment of cancer.
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公开(公告)号：EP4053122A1
公开(公告)日：2022-09-07
申请号：EP20882583.6
申请日：2020-10-29
发明人： YU, Ji-Hoon , IM, Chun Young , KIM, So Young , HAN, Ye Ri , LEE, Doohyun , JEON, Hui-Jeon , MIN, Sang-Hyun , OH, Bae Jun , PARK, Sang-Wook , CHOI, Dong-Kyu , KIM, Young-Kyu , KIM, Sung Hwan , LEE, Yuri , LEE, Seungyeon , KIM, Nam Hui , KIM, Sang Bum , MIN, Ju-Sik
IPC分类号： C07D405/14 , C07D405/12 , A61K31/496 , A61P35/00
摘要： The present invention relates to a compound comprising an EZH2 inhibitor and an E3 ligase binder, and a pharmaceutical composition for preventing or treating EZH2-associated disease and a pharmaceutical composition for selective protein degradation containing the same as an active ingredient. Since the compound of the present invention can selectively degrade EZH2, it can be effectively used for the treatment of EZH2-related diseases and cancers, particularly, cancers in which EZH2 is overexpressed, and can be usefully used for the selective degradation of EZH2.
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公开(公告)号：EP3587422A2
公开(公告)日：2020-01-01
申请号：EP18757481.9
申请日：2018-02-22
申请人： Daegu-Gyeongbuk Medical Innovation Foundation , National Cancer Center , Samsung Life Public Welfare Foundation
发明人： CHOI, Hwan Geun , PARK, Jong Bae , KO, Eunhwa , SON, Jung Beom , CHO, Joong-heui , KO, Yi Kyung , PARK, Jin-Hee , KIM, So Young , KANG, Seock Yong , LEE, Seungyeon , KIM, Nam Doo , LEE, Yunho , LEE, Sun-Hwa , KIM, Dayea , LEE, Sun Joo , BAE, Jae Hyun , HONG, Eunmi , JANG, Tae-ho , KIM, Sang Bum , LEE, Seung Hoon , NAM, Do-Hyun
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A23L33/10
摘要： The present invention relates to a novel pyrrolo-pyrimidine derivative compound, a preparation method therefor, and a pharmaceutical composition comprising the same compound as an effective ingredient for preventing or treating a protein kinase-related disease. The compound represented by Chemical Formula 1 according to the present invention, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an effective ingredient has outstanding inhibitory activity against LRRK2 kinase and against phosphorylation in the NIH-3T3 cell line, which is an LRRK2-expressing cell line, and NCC01 and 448T cell lines, which are both derived from patients with brain tumors. Verified to have inhibitory activity against various protein kinases in addition to LRRK2, the compound can find effective applications in the treatment or prevention of protein kinase-related diseases.
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