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    MARKERS TO PREDICT MACROCYCLIC LACTONE DRUG RESISTANCE IN DIROFILARIA IMMITIS, THE CAUSATIVE AGENT OF HEARTWORM DISEASE
    1.
    发明公开
    MARKERS TO PREDICT MACROCYCLIC LACTONE DRUG RESISTANCE IN DIROFILARIA IMMITIS, THE CAUSATIVE AGENT OF HEARTWORM DISEASE 审中-公开
    标志物耐大环内酯活跃于心丝虫预测，心脏病WORM的代理人

    公开(公告)号：EP3013977A2

    公开(公告)日：2016-05-04

    申请号：EP14742404.8

    申请日：2014-06-25

    申请人： ELANCO US INC. ,  McGill University

    发明人： PRICHARD, Roger ,  BOURGUINAT, Catherine ,  GEARY, Timothy

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q1/6888 ,  C12Q2600/124 ,  C12Q2600/136 ,  C12Q2600/156

    摘要： Disclosed are nucleic acid molecules from the genome of Dirofilaria spp. nematodes that contain single nucleotide polymorphisms related to reduced responsiveness of the nematodes to macrocyclic lactones. In one example, the species of Dirofilaria is Dirofilaria immitis (the agent of heartworm in animals). Also disclosed are methods for determining the responsiveness of Dirofilaria spp. nematodes to macrocyclic lactones, methods for selecting a treatment to treat an animal infected with a Dirofilaria spp. nematode, and kits for determining the responsiveness of Dirofilaria spp. nematodes to macrocyclic lactones.

    摘要翻译： 公开的是从犬恶菌的基因组中的核酸分子。 线虫确实含有与减少线虫到大环内酯类的响应性的单核苷酸多态性。 在一个实施例，犬恶的种是犬恶丝虫（丝虫在动物中的试剂）。 所以光盘游离缺失是确定性的开采犬恶菌的响应方法。 线虫大环内酯类，对于选择治疗来治疗感染了犬恶菌的动物的方法。 线虫，和试剂盒确定性采矿犬恶菌的响应。 线虫大环内酯类。

    USE OF AVERMECTIN DERIVATIVE FOR INCREASING BIOAVAILABILITY AND EFFICACY OF MACROCYLIC LACTONES
    4.
    发明公开
    USE OF AVERMECTIN DERIVATIVE FOR INCREASING BIOAVAILABILITY AND EFFICACY OF MACROCYLIC LACTONES 审中-公开
    USING A除虫菌素衍生物对增强大环内酯类生物利用度与效果

    公开(公告)号：EP2768513A2

    公开(公告)日：2014-08-27

    申请号：EP12783158.4

    申请日：2012-10-18

    申请人： Institut National de la Recherche Agronomique (INRA) ,  The Royal Institution for the Advancement of Learning / McGill University

    发明人： LESPINE, Anne ,  PRICHARD, Roger ,  MENEZ, Cécile

    IPC分类号： A61K31/7048 ,  A61P33/00 ,  A61P35/00 ,  A61P31/12 ,  A61P25/08

    摘要： The present invention relates to the use of avermectin derivative as a drug for the treatment of parasitic infections. The avermectin derivative is represented by the formula (I) wherein: (i) R1 is chosen from the group constituted of —CH(CH3)2, —CH(CH3)CH2CH3, or cyclohexyle, (ii) X represents —CH2CH2—, or —CH═CH—, (iii) R2 is chosen from the group constituted of or —OH group, (iv) R3 is OH or NOH, (v) represents a single bond when R3 is OH, or a double bond when R3 is NOH, as an inhibitor of a membrane-bound protein which transports exogenous compounds out of target cells.

    摘要翻译： 本发明涉及使用阿维菌素衍生物作为用于寄生虫感染的治疗的药物。 除虫菌素衍生物由式（I）表示：其中：（ⅰ）R 1是选自下组构成-CH（CH 3）2的，-CH（CH 3）CH 2 CH 3，或cyclohexyls，（ⅱ）X -CH 2 CH 2 darstellt， 或-CH = CH-，（ⅲ）R 2是选自下组的构成或-OH基团，（ⅳ）R 3为OH或NOH，（v）代表单键当R 3是OH，或双键时R3 是NOH，作为其输送外源性化合物出来的靶细胞的膜结合蛋白的抑制剂。