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公开(公告)号：EP2321268A2
公开(公告)日：2011-05-18
申请号：EP09781520.3
申请日：2009-08-05
发明人： BLANC, Jean-Baptiste , CHEN, Li , FIROOZNIA, Fariborz , GILLESPIE, Paul , GOODNOW, Robert, Alan, Jr. , HE, Yun , LIN, Tai-An , SO, Sung-Sau , YUN, HongYing , ZHANG, Zhenshan
IPC分类号： C07C311/20 , C07C311/29 , C07C323/67 , C07D213/34 , C07D213/71 , A61P11/00 , A61K31/18 , A61K31/395
CPC分类号： C07D213/71 , C07C311/20 , C07C311/29 , C07C317/14 , C07C323/67 , C07C2602/10 , C07D213/34 , C07D409/04
摘要： The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, wherein R
1 -R
5 , A, B, Q, W, and X are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和酯，其中R 1 -R 5，A，B，Q，W和X在具体实施方式和权利要求书中定义。 另外，本发明涉及制备和使用式（I）化合物的方法以及含有这些化合物的药物组合物。 式（I）化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号：EP2307382A1
公开(公告)日：2011-04-13
申请号：EP09780159.1
申请日：2009-07-06
发明人： CHEN, Li , FIROOZNIA, Fariborz , GILLESPIE, Paul , HE, Yun , LIN, Tai-An , SO, Sung-Sau , YUN, HongYing
IPC分类号： C07D231/56 , C07D401/12 , A61K31/416 , A61P37/00
CPC分类号： C07D231/56 , C07D401/12
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1 -R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
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公开(公告)号：EP2346819B1
公开(公告)日：2013-04-10
申请号：EP09751894.8
申请日：2009-11-09
发明人： CHEN, Li , FIROOZNIA, Fariborz , GILLESPIE, Paul , HE, Yun , LIN, Tai-An , MERTZ, Eric , SO, Sung-Sau , YUN, HongYing , ZHANG, Zhenshan
IPC分类号： C07C317/14 , C07C317/22 , C07C317/36 , C07D213/71 , C07D295/26 , A61K31/435 , A61K31/185 , A61P11/06 , A61P17/00 , A61P37/00 , A61P11/00
CPC分类号： C07D213/71 , C07C255/54 , C07C311/29 , C07C317/22 , C07C317/36 , C07C317/44 , C07C317/46 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07D211/38 , C07D295/26 , C07D491/10
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公开(公告)号：EP2307382B1
公开(公告)日：2011-12-21
申请号：EP09780159.1
申请日：2009-07-06
发明人： CHEN, Li , FIROOZNIA, Fariborz , GILLESPIE, Paul , HE, Yun , LIN, Tai-An , SO, Sung-Sau , YUN, HongYing
IPC分类号： C07D231/56 , C07D401/12 , A61K31/416 , A61P37/00
CPC分类号： C07D231/56 , C07D401/12
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1 -R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中Q，R 1 -R 3和n在具体实施方式和权利要求书中定义。 另外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号：EP2346807A1
公开(公告)日：2011-07-27
申请号：EP09748339.0
申请日：2009-11-09
发明人： FIROOZNIA, Fariborz , GILLESPIE, Paul , LIN, Tai-An , MERTZ, Eric , SIDDURI, Achyutharao , SO, Sung-Sau , TAN, Jenny , THAKKAR, Kshitij Chhabilbhai
IPC分类号： C07C57/58 , C07C69/78 , C07C231/12 , C07C255/57 , C07C311/16 , C07C317/24 , C07D231/12 , C07D257/04 , C07D317/70 , C07D295/26 , A61K31/192 , A61K31/216 , A61K31/277 , A61K31/36 , A61P11/06
CPC分类号： C07D295/26 , C07C57/58 , C07C59/68 , C07C69/76 , C07C255/57 , C07C311/16 , C07C311/29 , C07C317/44 , C07C317/46 , C07C323/62 , C07D231/12 , C07D239/26 , C07D257/04 , C07D317/70
摘要： The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R
1 -R
6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和酯，其中X，Q和R 1 -R 6在具体实施方式和权利要求书中定义。 另外，本发明涉及制备和使用式（I）化合物的方法以及含有这些化合物的药物组合物。 式（I）化合物是CRTH2受体的拮抗剂或部分激动剂，并可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号：EP2346819A1
公开(公告)日：2011-07-27
申请号：EP09751894.8
申请日：2009-11-09
发明人： CHEN, Li , FIROOZNIA, Fariborz , GILLESPIE, Paul , HE, Yun , LIN, Tai-An , MERTZ, Eric , SO, Sung-Sau , YUN, HongYing , ZHANG, Zhenshan
IPC分类号： C07C317/14 , C07C317/22 , C07C317/36 , C07D213/71 , C07D295/26 , A61K31/435 , A61K31/185 , A61P11/06 , A61P17/00 , A61P37/00 , A61P11/00
CPC分类号： C07D213/71 , C07C255/54 , C07C311/29 , C07C317/22 , C07C317/36 , C07C317/44 , C07C317/46 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07D211/38 , C07D295/26 , C07D491/10
摘要： The invention is concerned with the compounds of formula I, and pharmaceutically acceptable salts and esters thereof, wherein W, X, Y, and R
1 - R
7 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中W，X，Y和R 1 -R 7在详细描述和权利要求书中定义。 另外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂或部分激动剂，并可用于治疗与该受体相关的疾病和病症如哮喘。
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7.发明授权[4-(PIPERIDIN-4-YL)-NAPHTHALEN-2-YL]-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS FOR THE TREATMENT OF RESPIRATORY DISORDERS 有权[4-（哌啶-4-基） - 萘-2-基]作为CRTH2拮抗剂的乙酸衍生物呼吸系统疾病的治疗
公开(公告)号：EP2791111B1
公开(公告)日：2017-01-18
申请号：EP12805511.8
申请日：2012-12-10
发明人： FIROOZNIA, Fariborz , LIN, Tai-An , MERTZ, Eric , SIDDURI, Achyutharao , SO, Sung-Sau , TILLEY, Jefferson Wright
IPC分类号： C07D211/18 , C07D211/96 , A61K31/451 , A61P11/00 , A61P11/06 , A61P11/08
CPC分类号： C07D401/12 , C07D211/18 , C07D211/34 , C07D211/96
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公开(公告)号：EP2403846B1
公开(公告)日：2016-11-02
申请号：EP10705373.8
申请日：2010-02-25
发明人： BERTHEL, Steven Joseph , FIROOZNIA, Fariborz , FISHLOCK, Daniel , HONG, Jun-Bae , LOU, Yan , LUCAS, Matthew C. , OWENS, Thimothy D. , SARMA, Keshab , SWEENEY, Zachary Kevin , TAYGERLY, Joshua Paul Gergely
IPC分类号： C07D403/14 , A61K31/502 , A61P19/02 , A61P29/00
CPC分类号： C07D401/10 , C07D401/14 , C07D403/14 , C07D413/14
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公开(公告)号：EP2403846A1
公开(公告)日：2012-01-11
申请号：EP10705373.8
申请日：2010-02-25
发明人： BERTHEL, Steven Joseph , FIROOZNIA, Fariborz , FISHLOCK, Daniel , HONG, Jun-Bae , LOU, Yan , LUCAS, Matthew C. , OWENS, Thimothy D. , SARMA, Keshab , SWEENEY, Zachary Kevin , TAYGERLY, Joshua Paul Gergely
IPC分类号： C07D401/10 , C07D401/14 , C07D403/14 , C07D413/14 , A61K31/4412 , A61K31/444 , A61K31/497 , A61K31/501 , A61P19/02 , A61P29/00
CPC分类号： C07D401/10 , C07D401/14 , C07D403/14 , C07D413/14
摘要： This application discloses compounds according to general Formula (A) wherein, variable Z* is defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula (A) and at least one carrier, diluent or excipient.
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10.发明公开NAPHTHYLACETIC ACIDS USED AS CRTH2 ANTAGONISTS OR PARTIAL AGONISTS 有权作为CRTH2拮抗剂或部分激动剂二手CRTH2NAPHTHYLESSIGSÄUREN
公开(公告)号：EP2358677A1
公开(公告)日：2011-08-24
申请号：EP09748340.8
申请日：2009-11-09
发明人： FIROOZNIA, Fariborz , LIN, Tai-An , SO, Sung-Sau , WANG, Baoxia , YUN, HongYing
IPC分类号： C07D213/74 , C07D239/42 , C07D295/18 , C07D401/12 , C07D487/10 , C07D295/192 , A61K31/337 , A61K31/4402 , A61K31/505 , A61P11/00 , A61P11/06 , A61P17/00
CPC分类号： C07D295/192 , C07D213/74 , C07D239/42 , C07D295/18 , C07D401/12 , C07D487/10
摘要： The invention is concerned with the compounds of formula I and pharmaceutically acceptable salts and esters thereof, wherein X, Q and R1 -R3 are defined in the detailed description and claims. The invention is also concerned with the compounds of formula Z and pharmaceutically acceptable salts and esters thereof, wherein R1-R3 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I and Z as well as pharmaceutical compositions containing such compounds. The compounds of formula I and Z are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
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