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13 条记录 (耗时 0.011 秒)

    Method and apparatus for investigating and controlling an object
    1.
    发明公开
    Method and apparatus for investigating and controlling an object 失效
    用于调查和控制对象的方法和装置

    公开(公告)号：EP0468705A3

    公开(公告)日：1992-04-15

    申请号：EP91306551.2

    申请日：1991-07-18

    申请人： HITACHI, LTD.

    发明人： Maruhashi, Fumio ,  Haga, Ryoichi ,  Nakano, Ryusei ,  Nishimura, Nobuko ,  Matsuzaki, Harumi

    IPC分类号： G01N15/14 ,  C12M1/34 ,  F23N5/08

    CPC分类号： C12M41/46 ,  C12M41/36 ,  G01N15/1468 ,  Y10S435/808

    摘要： In order to investigate an object, such as a culture of micro-organisms, the image of the object is repeatedly picked up at two different magnifications by a suitable image pick-up device (21, 22, 24). The images at the two different magnifications are then analysed by a suitable picture image recognition device (25, 31) and the results of the repeated analysis are compared, thereby to derive a measurement of the change in the object with time. Thus, for a culture of micro-organisms, the number of cells can be determined at one magnification and the number of microscopic spherical bodies can be determined at another magnification, to obtain a measure of the activity of the culture. Preferably, one or more conditions of the object are then controlled on the basis of the measurement of change.

    Apparatus for culturing animal cells, method of culturing thereof and diagnostics of the culture
    2.
    发明公开
    Apparatus for culturing animal cells, method of culturing thereof and diagnostics of the culture 失效
    对于动物细胞，培养方法以及用于检测培养装置的培养装置。

    公开(公告)号：EP0340783A2

    公开(公告)日：1989-11-08

    申请号：EP89108110.1

    申请日：1989-05-05

    申请人： HITACHI, LTD.

    发明人： Matsuzaki, Harumi ,  Haga, Ryoichi ,  Nishimura, Yuusaku ,  Baba, Kenji ,  Maruhashi, Fumio ,  Nishimura, Nobuko ,  Ishida, Masahiko ,  Saitoh, Setuo

    IPC分类号： C12M3/00 ,  C12M1/34 ,  C12M1/36

    CPC分类号： G01N33/5005 ,  C12M41/36 ,  C12M41/46 ,  C12N1/12 ,  C12N1/20 ,  Y10S435/808 ,  Y10S435/813

    摘要： This invention provides an apparatus for culturing animal cells, which comprises diagnosis means to make it possible to diagnose by measuring sizes of the cells by means of image processing while a system of culturing the animal cells is cut off from the outside of the apparatus system, control means to control the culture conditions of a culturing cistern on the basis of a result of the diagnosis, and culture medium re­generating means to remove waste contents in a culture medium. In the apparatus of this invention, the culture system and diagnosis system are cut off from the outside of the apparatus system. Therefore, no infection of miscellaneous microorganism, etc., occurs, nor does consumption of valuable cells and products occur. Further, since it is possible to easily obtain data of the proportions of division potential-possessing cells and living cells, the environmental factors to the culturing cistern can be easily and instantly controlled based on the data, and therefore, the culturing efficiency can be enhanced.

    摘要翻译： 本发明提供的装置用于培养动物细胞的方法，其包括诊断手段，使之有可能通过测量细胞的大小，通过图像处理的手段，同时培养动物细胞的系统是从装置系统的外部切断诊断， 控制装置，以控制该诊断结果的基础上，一个水箱培养的培养条件，和培养基再生装置以除去在培养基中废物的内容。 在本发明的装置中，所述培养系统和诊断系统从装置系统的外部切断。因此，没有感染杂微生物等，该情况发生时，也不有价值的细胞和产品发生的消耗。 另外，由于能够容易地获得分割电位波塞的比例的数据唱细胞和活细胞，环境因素对培养水箱能够容易地并即时控制基于所述数据，并且因此，培养效率提高 ，

    Method for cultivation with acetate concentration monitoring and apparatus for the same
    8.
    发明公开
    Method for cultivation with acetate concentration monitoring and apparatus for the same 失效
    Verfahren zurZüchtungdurch Kontrollieren der Acetatkonzentration und Apparatdafür。

    公开(公告)号：EP0283726A1

    公开(公告)日：1988-09-28

    申请号：EP88102463.2

    申请日：1988-02-19

    申请人： HITACHI, LTD.

    发明人： Shimizu, Norio ,  Fukuzono, Shinichi ,  Fujimori, Kiyoshi ,  Nishimura, Nobuko ,  Odawara, Yoji

    IPC分类号： C12P1/00 ,  C12M1/36 ,  C12P21/02

    CPC分类号： C12M41/32 ,  C12M41/48 ,  C12P1/00 ,  C12P21/02 ,  Y10S435/849

    摘要： In a method for cultivation of microorganisms or animal cell or plant cells to produce metabolites, high density cultivation, high cell yield and high production of desired products can be achieved by performing culti­vation through monitoring acetate concentration in culture broth and regulating assimilation of acetate in the culture broth by the microorganisms or animal cell or plant cells to control the acetate concentration to a set value or less, and as an apparatus for such cultivation, preferred is an apparatus comprising a culture tank for performing cultivation, an acetate concentration analyzer in culture broth, a substrate tank for storing substrate, a substrate feeding device of variable flow type for feeding substrate and a control device for outputting a signal for controlling a substrate flow from the substrate feeding device based on a signal from the analyzer.

    摘要翻译： 在培养微生物或动物细胞或植物细胞以产生代谢物的方法中，可以通过监测培养液中的乙酸盐浓度并调节乙酸盐的同化来实现培养，从而实现高密度培养，高产量和高产量的所需产物 通过微生物或动物细胞或植物细胞培养培养液以控制乙酸盐浓度达到设定值或更低，作为这样的培养装置，优选包括用于进行培养的培养罐，培养液中的乙酸盐浓度分析仪 ，用于存储基板的基板罐，用于进给基板的可变流动型的基板供给装置和基于来自分析器的信号从基板供给装置输出用于控制基板流的信号的控制装置。