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11 条记录 (耗时 0.015 秒)

    AUTOMATIC ANALYTICAL APPARATUS
    2.
    发明公开
    AUTOMATIC ANALYTICAL APPARATUS 审中-公开
    自动分析仪器

    公开(公告)号：EP3101416A1

    公开(公告)日：2016-12-07

    申请号：EP15741107.5

    申请日：2015-01-09

    申请人： Hitachi High-Technologies Corporation

    发明人： IMAI, Kenta ,  NEGISHI, Yoshinori ,  SAKURAI, Toshinari ,  IMAI, Kyoko

    IPC分类号： G01N27/416 ,  G01N27/28 ,  G01N35/08

    CPC分类号： G01N35/0098 ,  G01N27/4163 ,  G01N27/49 ,  G01N35/1095

    摘要： When a sample of biological origin is analyzed using an electrochemical process, particularly in cases in which an aqueous solution is used as the measurement medium, when a voltage of +1.2 V or greater (herein, with saturated silver-silver chloride electrode potential as a reference) is applied, there are instances in which bubbles are observed to be produced within the flow cell, due to an electrolysis reaction deriving from the measurement buffer. There is a possibility that bubbles produced on the electrode will cover the electrode surface, reducing the effective surface area of the electrode. There is moreover a possibility that the distribution of magnetic particles captured on the electrode will be disturbed by the gas produced thereby, lowering the reproducibility of the results of the analysis. In view of the foregoing problem, the present invention provides a means for deaeration of the measurement medium prior to introduction of the measurement medium into the detector, thereby minimizing the effects of bubble production in degrading the analytical capability, and providing an automatic analytical apparatus with which it is possible to carry out highly sensitive electrochemical analysis.

    摘要翻译： 当使用电化学方法分析生物来源的样品时，特别是在使用水溶液作为测量介质的情况下，当+ 1.2V或更高的电压（在此，具有饱和的银 - 氯化银电极电位作为 由于来自测量缓冲液的电解反应，存在观察到在流通池内产生气泡的情况。 电极上产生的气泡可能会覆盖电极表面，从而降低电极的有效表面积。 此外，捕获在电极上的磁性粒子的分布受到由此产生的气体的干扰，从而降低了分析结果的再现性。 鉴于上述问题，本发明提供了一种在将测量介质引入检测器之前对测量介质进行脱气的装置，从而使气泡产生对分析能力降低的影响最小化，并且提供一种自动分析装置 这可以进行高灵敏度的电化学分析。

    NUCLEIC ACID ANALYSIS METHOD AND ANALYSIS APPARATUS
    3.
    发明公开
    NUCLEIC ACID ANALYSIS METHOD AND ANALYSIS APPARATUS 有权
    NUKLEINSÄURE-ANALYSEVERFAHREN UND-ANALYSEVORRICHTUNG

    公开(公告)号：EP2735618A1

    公开(公告)日：2014-05-28

    申请号：EP12815243.6

    申请日：2012-05-16

    申请人： Hitachi High-Technologies Corporation

    发明人： SAITO, Toshiro ,  HAMASAKI, Koshin ,  TAKAHASHI, Satoshi ,  MAESHIMA, Muneo ,  IMAI, Kyoko ,  IMAI, Kazumichi ,  TAO, Ryuji

    IPC分类号： C12Q1/68 ,  C12M1/34 ,  C12N15/09

    CPC分类号： C12Q1/6834 ,  C12N15/1065 ,  C12Q2525/207 ,  C12Q2537/125 ,  C12Q2537/143 ,  C12Q2563/143 ,  C12Q2563/149

    摘要： The object of the present invention is to provide a convenient method for nucleic acid analysis, which enables 1000 or more types of nucleic acid to be analyzed collectively with high comprehensiveness and with a dynamic range of at least four digits. In particular, provide is a very effective analytical method especially for untranslated RNAs and microRNAs, of which the types of target nucleic acids is 10000 or lower.
    The present invention enables nucleic acids to be analyzed conveniently and rapidly with high comprehensiveness and quantitative performance at single-molecule sensitivity and resolution by following the steps of: preparing a group of target nucleic acid fragments one molecule at a time and hybridizing the nucleic acid molecules, which have known base sequences and have been labeled with the fluorescence substances, with the group of the target nucleic acid fragments to detect the fluorescence substances labeling the hybridized nucleic acid molecules.

    摘要翻译： 本发明的目的是提供一种方便的核酸分析方法，其使得能够以高全面性和至少四位数的动态范围共同分析1000种或更多种类型的核酸。 特别地，提供一种非常有效的分析方法，特别是对于非翻译的RNA和微RNA，其靶核酸的类型为10000或更低。 本发明通过以下步骤能够以单分子灵敏度和分辨率的高全面性和定量性能方便快速地分析核酸：一次一个分子制备一组靶核酸片段，并与核酸分子杂交 已知碱基序列并已用荧光物质标记，与靶核酸片段组一起检测标记杂交核酸分子的荧光物质。

    NUCLEIC ACID ANALYSIS METHOD
    7.
    发明授权
    NUCLEIC ACID ANALYSIS METHOD 有权
    核酸分析方法

    公开(公告)号：EP2735618B1

    公开(公告)日：2017-12-06

    申请号：EP12815243.6

    申请日：2012-05-16

    申请人： Hitachi High-Technologies Corporation

    发明人： SAITO, Toshiro ,  HAMASAKI, Koshin ,  TAKAHASHI, Satoshi ,  MAESHIMA, Muneo ,  IMAI, Kyoko ,  IMAI, Kazumichi ,  TAO, Ryuji

    IPC分类号： C12Q1/68 ,  C12M1/34 ,  C12N15/09

    CPC分类号： C12Q1/6834 ,  C12N15/1065 ,  C12Q2525/207 ,  C12Q2537/125 ,  C12Q2537/143 ,  C12Q2563/143 ,  C12Q2563/149

    摘要： The object of the present invention is to provide a convenient method for nucleic acid analysis, which enables 1000 or more types of nucleic acid to be analyzed collectively with high comprehensiveness and with a dynamic range of at least four digits. In particular, provide is a very effective analytical method especially for untranslated RNAs and microRNAs, of which the types of target nucleic acids is 10000 or lower. The present invention enables nucleic acids to be analyzed conveniently and rapidly with high comprehensiveness and quantitative performance at single-molecule sensitivity and resolution by following the steps of: preparing a group of target nucleic acid fragments one molecule at a time and hybridizing the nucleic acid molecules, which have known base sequences and have been labeled with the fluorescence substances, with the group of the target nucleic acid fragments to detect the fluorescence substances labeling the hybridized nucleic acid molecules.

    IMMUNOANALYSIS METHOD AND IMMUNOANALYSIS DEVICE
    10.
    发明公开
    IMMUNOANALYSIS METHOD AND IMMUNOANALYSIS DEVICE 审中-公开
    免疫球蛋白免疫缺陷病毒

    公开(公告)号：EP2881737A1

    公开(公告)日：2015-06-10

    申请号：EP13825065.9

    申请日：2013-06-21

    申请人： Hitachi High-Technologies Corporation

    发明人： IMAI, Kyoko ,  SAITO, Toshiro ,  IMAI, Kazumichi

    IPC分类号： G01N33/543 ,  G01N21/64 ,  G01N33/552 ,  G01N33/553 ,  G01N37/00

    CPC分类号： G01N33/54386 ,  G01N21/6428 ,  G01N21/6452 ,  G01N33/54326 ,  G01N33/54366

    摘要： An object of the present invention is to provide a highly sensitive immunoanalysis method and analysis apparatus. The invention relates to an analysis method and an analysis apparatus which are constituted in such a way that a component to be measured is reacted with a capture component specifically reacting thereto and the reactant is labeled when the component to be measured is present and which are characterized by analyzing the component to be measured with single-molecule sensitivity and resolution by arranging the labeled reactant in a spatially separated certain position and detecting the label of the labeled reactant.

    摘要翻译： 本发明的目的是提供高灵敏度的免疫分析方法和分析装置。 本发明涉及一种分析方法和分析装置，其以待测量的成分与特定地与其反应的捕获组分反应并且当待测量的组分存在时标记反应物，并且其特征在于 通过在空间分离的特定位置布置标记的反应物并检测标记的反应物的标记，通过分析具有单分子灵敏度和分辨率的待测量组分。