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    SENSOR DEVICE AND METHOD OF ITS USE
    4.
    发明公开
    SENSOR DEVICE AND METHOD OF ITS USE 审中-公开

    公开(公告)号：EP4016069A1

    公开(公告)日：2022-06-22

    申请号：EP20215882.0

    申请日：2020-12-21

    申请人： F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

    发明人： BOEHM, Christoph ,  BURKHARDT, Wolfgang ,  LUTZ, Sascha ,  OCVIRK, Gregor ,  RUF, Miriam ,  KONTSCHIEDER, Heinz

    IPC分类号： G01N27/27 ,  G01N27/327 ,  G01N27/333 ,  G01N33/49 ,  B01L3/00

    摘要： The present disclosure refers to a sensor device (1, 1'), a method of operating the sensor device (1, 1') and an IVD analyzer (100) for receiving the sensor device (1, 1') for determining chemical and/or physical characteristics of a fluid. The sensor device (1, 1') comprises at least two fluidic conduits (2, 2', 3) for repeatedly receiving fluids, each fluidic conduit (2, 2', 3) comprising at least one sensory element (11A, 11B, 12A, 12B, 13, 14, 15) arranged such as to come in contact with a fluid in the respective fluidic conduit (2, 2', 3). In particular, the fluidic conduits (2, 2', 3) comprise different sensory elements, respectively, wherein the sensory elements are separated in the respective fluidic conduits according to compatibility or susceptibility to deterioration or operating temperature. Alternately, the fluidic conduits (2, 2', 3) comprise at least in part the same sensory elements, wherein the sensor device (1, 1') is operated in a primary operating mode and in response to a trigger event, switches to an extended operating mode.

    BLOOD COLLECTOR WITH CAPILLARY STRUCTURE
    6.
    发明公开
    BLOOD COLLECTOR WITH CAPILLARY STRUCTURE 审中-公开
    具有毛细结构的血液收集器

    公开(公告)号：EP3184158A1

    公开(公告)日：2017-06-28

    申请号：EP15201585.5

    申请日：2015-12-21

    申请人： Roche Diagnostics GmbH ,  F. Hoffmann-La Roche AG

    发明人： BOEHM, Christoph ,  BRUECKNER, Thorsten ,  LUTZ, Sascha ,  ESROM, Bruntje ,  MICHAEL, Herbel

    IPC分类号： B01D17/02 ,  B01L3/00 ,  G01N33/49 ,  A61B5/15 ,  A61B5/157 ,  A61B10/00

    CPC分类号： G01N1/4077 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150343 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150832 ,  A61B5/157 ,  A61B10/0045 ,  B01D17/0217 ,  B01L3/5021 ,  B01L3/502753 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2300/043 ,  B01L2300/0803 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0409 ,  G01N21/07 ,  G01N21/84 ,  G01N33/491 ,  G01N2001/4083

    摘要： The invention provides for a method of determining an amount of an analyte in a blood sample (500) using a cartridge (100, 300, 600) and a blood collector (400, 800, 1200, 1513). The blood collector comprises: a mounting surface (402); a capillary structure (404) for holding the blood sample, wherein the capillary structure comprises a curved portion (406); a capillary inlet (403) for receiving the blood sample. The cartridge comprises: a receiving surface for attaching to the mounting surface; a cartridge inlet (108) for receiving the blood sample from the blood collector; a microfluidic structure (111) for processing the blood sample into a processed sample; a measurement structure (130) for enabling measurement of the processed sample to determine the amount of the analyte in the blood sample; wherein the method comprises: placing (1100, 1400) the blood sample into the capillary inlet; attaching (1104, 1404) the mounting surface to the receiving surface; rotating (1600) the cartridge about the rotational axis to transport the blood sample from the capillary structure to the cartridge inlet; rotating (1602) the cartridge about the rotational axis to transport the blood sample from the cartridge inlet into the microfluidic structure; controlling (1604) the rotation of the cartridge about the rotational axis to process the blood sample into the processed sample using the microfluidic structure; controlling (1606) the rotation of the cartridge to transfer the processed sample to the measurement structure; and measuring (1608) the amount of the analyte using the measurement structure and a measurement system.

    摘要翻译： 本发明提供了一种使用药筒（100,300,600）和血液收集器（400,800,1200,1513）确定血液样本（500）中的分析物的量的方法。 血液采集器包括：安装表面（402）; 毛细结构（404），其用于保持血样，其中所述毛细结构包括弯曲部分（406）; 毛细管入口（403），用于接收血液样本。 盒包括：用于附接到安装表面的接收表面; 药筒入口（108），用于从血液收集器接收血液样本; 用于将血液样本处理成处理后的样本的微流体结构（111） 测量结构（130），用于能够测量处理后的样品以确定血液样品中分析物的量; 其中该方法包括：将血样放置（1100,1400）到毛细管入口中; 将所述安装表面附接（1104,1404）到所述接收表面; 围绕所述旋转轴旋转（1600）所述盒以将所述血液样品从所述毛细结构传送到所述盒入口; 使所述盒围绕所述旋转轴线旋转（1602）以将所述血液样品从所述盒入口输送到所述微流体结构中; 使用所述微流体结构控制（1604）所述盒绕所述旋转轴线的旋转以将所述血液样本处理成所述处理过的样本; 控制（1606）盒的旋转以将处理后的样本传送到测量结构; 和使用测量结构和测量系统测量（1608）分析物的量。

    CARTRIDGE AND OPTICAL MEASUREMENT OF AN ANALYTE WITH SAID CARTRIDGE
    7.
    发明公开
    CARTRIDGE AND OPTICAL MEASUREMENT OF AN ANALYTE WITH SAID CARTRIDGE 审中-公开

    公开(公告)号：EP4023338A1

    公开(公告)日：2022-07-06

    申请号：EP22152474.7

    申请日：2016-04-14

    申请人： Roche Diagnostics GmbH ,  F. Hoffmann-La Roche AG

    发明人： BOEHM, Christoph ,  BRÜCKNER, Thorsten ,  LUTZ, Sascha

    IPC分类号： B01L3/00

    摘要： The invention provides for a method of performing an optical measurement (1132) of an analyte in a processed biological sample using a cartridge (100). The cartridge is operable for being spun around a rotational axis (108). The method comprises: placing the biological sample into a sample inlet (112); controlling (1200) the rotational rate of the cartridge to process a biological sample into the processed biological sample using a fluidic structure (110); controlling (1202) the rotational rate of the cartridge to allow the processed biological sample to flow from the measurement structure inlet to an absorbent structure via a chromatographic membrane, and performing (1204) an optical measurement of a detection zone (122) on the chromatographic membrane with an optical instrument. An inlet air baffle reduces evaporation of the processed biological sample from the chromatographic membrane during rotation of the cartridge

    SENSOR ASSEMBLY
    10.
    发明公开
    SENSOR ASSEMBLY 审中-公开

    公开(公告)号：EP4016068A1

    公开(公告)日：2022-06-22

    申请号：EP20215881.2

    申请日：2020-12-21

    申请人： F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

    发明人： BURKHARDT, Wolfgang ,  RUF, Miriam ,  BOEHM, Christoph ,  OCVIRK, Gregor

    IPC分类号： G01N27/27 ,  G01N27/327 ,  G01N27/333 ,  G01N33/49 ,  B01L3/00

    摘要： The present disclosure refers to a sensor assembly (1, 1', 1") for an IVD analyzer, the sensor assembly (1, 1', 1") comprising two opposite substrates (10A, 10B, 20A, 20B, 30A, 30B) with at least one fluidic conduit (2, 3, 4) for receiving a sample. The electrodes of different types of electrochemical sensors are arranged on the two opposite substrates (10A, 10B, 20A, 20B, 30A, 30B) facing the at least one fluidic conduit (2, 3, 4) for coming in contact with the sample and determining sample parameters, wherein the counter electrodes (11C, 11D) and the reference electrodes (11B, 12B) are formed on one substrate (10A, 10B, 20A, 20B, 30A, 30B) and the working electrodes (11A, 12A, 12A') are formed on the opposite substrate (10A, 10B, 20A, 20B, 30A, 30B). This achieves optimal sensor-working conditions in terms of a homogeneous and symmetrical electric field density and enables a sensor assembly with simpler geometry and smaller size.