公开(公告)号：EP1071826A4

公开(公告)日：2003-05-21

申请号：EP99922713

申请日：1999-04-13

申请人： ISIS PHARMACEUTICALS INC

发明人： COWSERT LEX M ,  BAKER BRENDA F ,  MCNEIL JOHN ,  FREIER SUSAN M ,  SASMOR HENRI M ,  BROOKS DOUGLAS G ,  OHASHI CARA ,  WYATT JACQUELINE R ,  BORCHERS ALEXANDER H ,  VICKERS TIMOTHY A

IPC分类号： C12N15/09 ,  C07B61/00 ,  C12N15/10 ,  C12Q1/68 ,  C40B30/02 ,  C40B40/02 ,  C40B50/02 ,  C40B50/06 ,  G06F17/30 ,  G06F17/50 ,  G06F19/18 ,  G06F19/22 ,  C12N15/11 ,  G06F19/00

CPC分类号： G06F19/18 ,  B01J2219/007 ,  C40B50/02 ,  G06F19/22

摘要： Iterative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is provided or selected, and a library of candidate nucleobase sequences is generated in silico according to defined criteria. A 'virtual' oligonucleotide chemistry is chosen and a library of virtual oligonucleotide compounds having the selected nucleobase sequences is generated. These virtual compounds are reviewed and compounds predicted to have particular properties are selected. The selected compounds are robotically synthesized and are preferably robotically assayed for a desired physical, chemical or biological activity. Active compounds are thus generated and, at the same time, preferred sequences and regions of the target nucleic acid that are amenable to oligonucleotide or sequence-based modulation are identified.

公开(公告)号：EP1248792A4

公开(公告)日：2004-11-17

申请号：EP01942628

申请日：2001-01-11

申请人： ISIS PHARMACEUTICALS INC

发明人： MCKAY ROBERT ,  BORCHERS ALEXANDER H ,  BAKER BRENDA F

IPC分类号： C12N15/09 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P1/00 ,  A61P3/10 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C12N15/113 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Peroxisome proliferator-activated receptor gamma. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Peroxisome proliferator-activated receptor gamma. Methods of using these compounds for modulation of Peroxisome proliferator-activated receptor gamma expression and for treatment of diseases associated with expression of Peroxisome proliferator-activated receptor gamma are provided.

公开(公告)号：EP1425293A4

公开(公告)日：2004-11-10

申请号：EP02768625

申请日：2002-08-21

申请人： ISIS PHARMACEUTICALS INC

发明人： BENNETT C FRANK ,  BORCHERS ALEXANDER H ,  KARRAS JAMES G

IPC分类号： C12N15/10 ,  C12N15/113 ,  C07H21/04 ,  C12N15/00

CPC分类号： C12N15/1136 ,  C12N15/1034 ,  Y02P20/582