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1.发明公开PEPTIDE FRAGMENTS HAVING CELL DEATH INHIBITORY ACTIVITY 有权PEPTIDFRAGMENTE MIT DEN ZELLTOD VERHINDERNDERAKTIVITÄT
公开(公告)号：EP1132402A1
公开(公告)日：2001-09-12
申请号：EP99972642.5
申请日：1999-11-12
CPC分类号： C07K14/4747 , A61K38/00
摘要： The present invention provides a peptide fragment or a series of peptide fragments having a cell death-inhibitory activity, having the amino acid sequence consisting of 103 amino acid residues at the C-terminal of selenoprotein P, or having said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or having a partial sequence of either of the above amino acid sequences, a medicament for treatment comprising said peptide fragment or a series of peptide fragments, an antibody to said peptide fragment or a series of peptide fragments, and a method for screening a cell death-inhibitory activity using said peptide fragment or a series of peptide fragments. The preferable peptide fragment or a series of peptide fragments of the present invention has the amino acid sequences shown in SEQ ID NO: 1 and/or SEQ ID NO: 2 or has a partial sequence thereof.
摘要翻译： 本发明提供具有细胞死亡抑制活性的肽片段或一系列肽片段，其具有由硒蛋白P的C末端上的103个氨基酸残基组成的氨基酸序列，或具有所述氨基酸序列与一个或多个 其中缺少，取代或添加的几个氨基酸残基或具有上述氨基酸序列之一的部分序列，包含所述肽片段或一系列肽片段的治疗药物，所述肽片段的抗体或一系列 的肽片段，以及使用所述肽片段或一系列肽片段筛选细胞死亡抑制活性的方法。 本发明优选的肽片段或一系列肽片段具有SEQ ID NO：1和/或SEQ ID NO：2所示的氨基酸序列或其部分序列。
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2.发明授权METHOD OF DETECTING THROMBOSIS BY MEASURING VON WILLEBRAND FACTOR-CLEAVING PROTEASE 有权检测方法的血栓通过测量血管性血友病因子裂解酶
公开(公告)号：EP1712918B1
公开(公告)日：2012-06-20
申请号：EP04807583.2
申请日：2004-12-22
申请人： Mitsubishi Chemical Medience Corporation , Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
IPC分类号： G01N33/573
CPC分类号： G01N33/6893 , G01N2333/95 , G01N2800/222 , G01N2800/226 , G01N2800/32 , Y10S436/811 , Y10T436/106664
摘要： A method of detecting the level of thrombus formation tendency or thrombosis through determining of the quantity of von Willebrand factor splitting enzyme. There is further disclosed a kit for detecting the level of thrombus formation tendency or thrombosis, which kit includes an antibody capable of specific binding to von Willebrand factor splitting enzyme, or a fragment of the antibody. The provided detection method and detection kit excel in convenience, speed and specificity.
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3.发明公开METHOD OF PREPARING PEPTIDE FRAGMENT HAVING CELL DEATH INHIBITORY ACTIVITY 审中-公开制备具有细胞死亡抑制活性的肽片段的方法
公开(公告)号：EP1418182A1
公开(公告)日：2004-05-12
申请号：EP02760561.7
申请日：2002-08-07
发明人： KAMEI, Shintaro , HAMAMOTO, Takayoshi , HIRASHIMA, Masaki , MAEDA, Hiroaki , TAKAHASHI, Kazuhiko
摘要： A process for preparing a peptide fragment having a cell death-inhibitory activity is provided. In order to obtain a selenoprotein P fragment having a cell death-inhibitory activity, full-length selenoprotein P was reacted with various serine proteinases and the resulting fragments were electrophoresed and assessed for a cell death-inhibitory activity. A process for preparing a selenoprotein P fragment was established by identifying an enzyme that produced bands corresponding to a molecular weight of not more than 3.5 x 10 4 in electrophoresis. A process for preparing a peptide fragment having a cell death-inhibitory activity according to the present invention may be used for amelioration, treatment and prevention of diseases caused by cell death and for more efficient production of useful living substances.
摘要翻译： 提供了制备具有细胞死亡抑制活性的肽片段的方法。 为了获得具有细胞死亡抑制活性的硒蛋白P片段，使全长硒蛋白P与各种丝氨酸蛋白酶反应，并对所得片段进行电泳并评估细胞死亡抑制活性。 通过鉴定在电泳中产生对应于分子量不超过3.5×10 4的条带的酶，建立了硒蛋白P片段的制备方法。 根据本发明的用于制备具有细胞死亡抑制活性的肽片段的方法可用于改善，治疗和预防由细胞死亡引起的疾病并用于更有效地生产有用的生物。
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公开(公告)号：EP1921140B1
公开(公告)日：2011-12-14
申请号：EP06780756.0
申请日：2006-07-04
发明人： KAMINAKA, Kazuyoshi , MAEDA, Hiroaki , HIRASHIMA, Masaki , KAWAMURA, Ryoichi , MATSUDA, Junichi , KUWANA, Takashi
IPC分类号： C12N15/09 , A01K67/027 , C12N5/10
CPC分类号： C12N15/79 , A01K2217/05 , A01K2227/30 , C12N15/102 , C12N15/85 , C12N15/90 , C12N2800/30 , C12N2800/90 , C12N2820/00
摘要： Disclosed are a mutant transposon vector and a method for introducing a foreign gene into a cell. A mutant transposon vector having a nucleic acid fragment inserted therein, the nucleic acid fragment having the properties (i) and (ii) or the properties (i) to (iii) below; a foreign gene-expressing cell which is prepared by introducing the mutant transposon vector into the chromosomal DNA of an established cell or a cell capable of being individuated and then additionally introducing a foreign gene-expressing cassette into a recombinant system (e.g., Cre-Lox system); a recombinant animal created by using the cell (in the case where the cell capable of being individuated is used); and a method for producing a foreign protein from the cell or the recombinant animal: (i) comprising a 5'-TIR sequence and a 3'-TIR sequence of transposon gene; (ii) having a sequence at which a recombination reaction occurs inserted between at least one set of DR regions of two sets of DR regions present in a 5'-TIR sequence or a 3'-TIR sequence of transposon gene; and (iii) having a restriction recognition site or a foreign gene-expressing cassette inserted between a 5'-TIR sequence and a 3'-TIR sequence of transposon gene.
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公开(公告)号：EP1132402B1
公开(公告)日：2009-05-27
申请号：EP99972642.5
申请日：1999-11-12
CPC分类号： C07K14/4747 , A61K38/00
摘要： Peptide fragment(s) having an activity of inhibiting cell death which contain the amino acid sequence consisting of 103 amino acid residues in the C-terminal side of selenoprotein P, an amino acid sequence derived from the above amino acid sequence by deletion, substitution or addition of one or several amino acids therein, or a partial sequence of either of the above amino acid sequences; remedies containing the above peptide fragment(s); antibodies against the above peptide fragment(s); and a method for screening a cell death inhibitory activity with the use of the above peptide fragment(s). Preferable examples of the above peptide fragment(s) are those containing the amino acid sequence(s) represented by SEQ ID NO:1 and/or 2 or partial sequences thereof.
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公开(公告)号：EP1921140A1
公开(公告)日：2008-05-14
申请号：EP06780756.0
申请日：2006-07-04
发明人： KAMINAKA, Kazuyoshi , MAEDA, Hiroaki , HIRASHIMA, Masaki , KAWAMURA, Ryoichi , MATSUDA, Junichi , KUWANA, Takashi
IPC分类号： C12N15/09 , A01K67/027 , C12N5/10
CPC分类号： C12N15/79 , A01K2217/05 , A01K2227/30 , C12N15/102 , C12N15/85 , C12N15/90 , C12N2800/30 , C12N2800/90 , C12N2820/00
摘要： A modified transposon vector and a method for introducing a foreign gene into a cell are provided. A modified transposon vector wherein a nucleic acid fragment having the following features (a)-(b) or (a)-(c) is inserted; a cell expressing a foreign gene obtained by introducing said vector into chromosomal DNA of a cell line or an ontogenetic cell and further introducing an expression cassette of a foreign gene into the chromosomal DNA; a genetically recombined animal generated by using said cell (in case of an ontogenetic cell); and a method for producing a foreign protein from said cell and said genetically recombined animal:
(a) It consists of 5'- and 3'-TIR sequences of a transposon gene; (b) A sequence where a recombination reaction occurs is inserted between at least either of DR regions present by twos each in 5'- and 3'-TIR sequences of a transposon gene; (c) A restriction enzyme recognition site or an expression cassette of a foreign gene is inserted between 5'- and 3'-TIR sequences of a transposon gene.-
8.发明公开
公开(公告)号：EP1566181A1
公开(公告)日：2005-08-24
申请号：EP03812336.0
申请日：2003-11-28
发明人： KAWAMURA, Ryoichi , NARUSE, Takeshi , HIRASHIMA, Masaki , KAMINAKA, Kazuyoshi , MATSUDA, Junichi , MAEDA, Hiroaki , NODA, Mami , WADA, Keiji
IPC分类号： A61K38/17 , A61P1/00 , A61P3/12 , A61P9/00 , A61P15/10 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/06 , A61P39/02 , A61P43/00
CPC分类号： A61K38/1709
摘要： A novel medicament for ameliorating neurotransmission dysfunction diseases is provided. A medicament for ameliorating neurotransmission dysfunction diseases comprising as a main active ingredient preferably a selenocysteine-containing protein such as Selenoprotein P or a selenocysteine-containing peptide that consists of said protein or a series of said peptides. A medicament suited for ameliorating neurotransmission dysfunction diseases caused by various pathological conditions is provided.
摘要翻译： 提供了用于改善神经传递功能障碍疾病的新型药物。 一种用于改善神经传递功能障碍疾病的药物，其包含主要活性成分，优选含有硒代半胱氨酸的蛋白质如硒蛋白P或含有所述蛋白质或一系列所述肽的含硒代半胱氨酸的肽。 提供了适用于改善由各种病理状况引起的神经传递功能障碍疾病的药物。
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公开(公告)号：EP1437410A1
公开(公告)日：2004-07-14
申请号：EP02767954.7
申请日：2002-09-12
发明人： KAMINAKA, Sara , KAMINAKA, Kazuyoshi , HIRASHIMA, Masaki , MAEDA, Hiroaki , NOZAKI, Chikateru , TAKAHASHI, Kazuhiko
CPC分类号： C12N9/0065 , C07K14/765 , C07K2319/00
摘要： A novel selenocysteine-containing protein is provided which is a substantial entity having an enzymatic activity, typically an activity to reduce peroxide phospholipids. There are provided a gene consisting of a coding sequence for a protein not containing selenocysteine in which the codon for selenocysteine is introduced at a desired position and a selenocysteine insertion sequence resided at the 3'-end of said coding sequence and a protein expressed therefrom, typically a selenocysteine-containing protein having an activity to reduce peroxide phospholipids which is prepared by introducing selenocysteine into albumin and as well as a gene encoding said protein. A novel anti-oxidative substance is provided which can be applied for prevention of worsening, prophylaxis or treatment of various diseases associated with oxidative stress.
摘要翻译： 含有通过将一个或多个硒代半胱氨酸插入或取代含有硒代半胱氨酸的蛋白质并具有酶活性的骨架形成的重组硒蛋白的蛋白质是新的。 还包括以下独立权利要求：（1）编码这种重组的含半胱氨酸的蛋白质的基因; 和（2）通过使用该基因产生重组的含半胱氨酸的蛋白质。 活性：免疫调节剂; 抑制细胞生长; Cardiant; 精神药物; 神经保护; 降血糖; 眼科。 行动机制：源材料无。
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10.发明公开
公开(公告)号：EP1374887A1
公开(公告)日：2004-01-02
申请号：EP01961246.4
申请日：2001-08-31
CPC分类号： A61K38/1709
摘要： A novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from said protein is provided. The novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, according to the present invention is suitably applicable to diseases with decrease in motor function.
摘要翻译： 提供了用于治疗神经变性疾病，特别是用于改善运动障碍的新型药物，其包含作为活性成分的硒蛋白P和/或肽片段或一系列源自所述蛋白质的肽片段。 根据本发明的用于治疗神经变性疾病，特别是用于改善运动障碍的新型药物适用于运动功能降低的疾病。
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