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41 条记录 (耗时 0.018 秒)

    Anticonvulsive compounds
    7.
    发明公开
    Anticonvulsive compounds 失效
    有毒化合物

    公开(公告)号：EP0162669A3

    公开(公告)日：1986-11-20

    申请号：EP85303451

    申请日：1985-05-16

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Teranishi, Masayuki ,  Murakata, Chikara ,  Matsukuma, Ikuo ,  Shuto, Katsuichi ,  Ichikawa, Shunji

    IPC分类号： A61K31/505 ,  C07D239/22

    CPC分类号： C07D239/22 ,  A61K31/505

    摘要： For use an an anticonvulsive: dihydrouracil compounds of the formula
    where one of A and B is
    (where Y, Y 2 and Y 3 are each H, C 1 -C 4 straight- or branched-chain alkyl, halogen, nitro, amino. carboxyl, alkoxycarbonyl of 2-7 carbon atoms or -CF 3 ), naphthyl or diphenylmethyl and the other is H, C 1 -C 6 straight- or branched-chain alkyl, C 1 -C 6 alkenyl, cyclopentyl, cyclohexyl or
    (where Z 1 , Z 2 and Z 3 are each H, C 1 -C 4 straight- or branched-chain alkyl, halogen or -CF 3 ); X is 0 or S; and R 1 , R 2 and R 3 are each H or C 1 -C 3 straight- or branched-chain alkyl.

    Novel piperidine derivatives and pharmaceutical compositions containing same
    8.
    发明公开
    Novel piperidine derivatives and pharmaceutical compositions containing same 失效
    新型哌啶衍生物和含有其的药物组合物

    公开(公告)号：EP0092391A3

    公开(公告)日：1984-09-26

    申请号：EP83302123

    申请日：1983-04-14

    申请人： KYOWA HAKKO KOGYO CO., LTD

    发明人： Teranishi, Masayuki ,  Obase, Hiroyuki ,  Nomoto, Yuji ,  Shuto, Katsuichi ,  Karasawa, Akira ,  Kasuya, Yutaka

    IPC分类号： C07D401/06 ,  C07D401/04 ,  A61K31/445 ,  C07D211/58 ,  C07D211/26

    CPC分类号： C07D401/04 ,  C07D211/26 ,  C07D211/58 ,  C07D401/06

    摘要： Novel piperidine derivatives are disclosed having hypotensive activity, as well as pharmaceutical preparations containing them. The novel compounds are of the formula
    wherein A is a hydroxyl group, a halogen atom, a C,-C 5 alkyl group, a C 1 -C 5 alkoxy group, a C 2 -C 5 alkenyloxy group, a C 1 -C 5 alkinyloxy group, a C 1 -C 5 alkylthio group, a carboxyl group, a C 1 -C 5 alkoxycarbonyl group, a nitro group, an amino group, a C 1 -C 5 alkylamino group, a C,-C 5 alkanoylamino group, a sulfamoyl group, a mono- or di- (C 1 -C 5 alkyl) aminosulfonyl group, a C 1 -C 5 alkylsulfonyl group, a carbamoyl group, a cyano group or a trifluoromethyl group; when m is 2 or more, A may be the same or different groups, or two A groups may combine to form a C,-C 5 alkylenedioxy group; m is 0 or an integer of 1-5; Q is a carbonyl group or a hydroxymethylene group; R is a hydrogen atom or an alkyl group having 1-4 carbon atoms; X and Y are defined as follows: i) when Y = H, X represents
    ii) when Y = CH 3 , X represents
    and when
    X represents a hydrogen atom and their pharmacologically acceptable acid addition salts.

    摘要翻译： 公开了具有降血压活性的新型哌啶衍生物，以及含有它们的药物制剂。 该新化合物具有式CHEM，其中A为羟基，卤原子，C1-C5烷基，C1-C5烷氧基，C7-C5链烯氧基，C1-C5烷氧基， C1-C5烷硫基，羧基，C1-C5烷氧基羰基，硝基，氨基，C1-C5烷基氨基，C1-C5烷酰基氨基，氨磺酰基，一或二（ C1-C5烷基）氨基磺酰基，C1-C5烷基磺酰基，氨基甲酰基，氰基或三氟甲基; 当m为2以上时，A可以相同或不同，或两个A基团可以结合形成C1-C5亚烷基二氧基; m为0或1-5的整数; Q是羰基或羟基亚甲基; R是氢原子或具有1-4个碳原子的醇酸基; X和Y定义如下：i）当Y = H时，X表示 ii）当Y = CH 3时，X表示，当Y = CHEM时，X表示氢原子及其药理学上可接受的酸加成盐 。