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公开(公告)号：EP3215001A4
公开(公告)日：2018-04-04
申请号：EP15857521
申请日：2015-11-03
申请人： LUXCATH LLC
IPC分类号： A61B5/00
CPC分类号： A61B18/1492 , A61B18/18 , A61B18/22 , A61B2017/00057 , A61B2018/00577 , A61B2018/0212 , A61B2090/065 , A61B2090/3784 , A61B2218/002
摘要： Ablation and visualization systems and methods to access quality of contact between a catheter and tissue are provided. In some embodiments, a method for monitoring tissue ablation of the present disclosure comprises advancing a distal tip of an ablation catheter to a tissue in need of ablation; illuminating the tissue with UV light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both; determining from a level of NADH fluorescence in the illuminated tissue when the distal tip of the catheter is in contact with the tissue; and delivering ablation energy to the tissue to form a lesion in the tissue.
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公开(公告)号：EP2757933A4
公开(公告)日：2015-07-01
申请号：EP12834435
申请日：2012-09-22
发明人： AMIRANA OMAR , ARMSTRONG KENNETH C , KAY MATTHEW W , MERCADER MARCO A , RANSBURY TERRANCE J , SARVAZYAN NARINE
IPC分类号： A61B1/06 , A61B1/00 , A61B1/04 , A61B1/05 , A61B5/00 , A61B5/145 , A61B5/1459 , A61B18/00 , A61B18/02 , A61B18/14
CPC分类号： A61B5/0071 , A61B1/00045 , A61B1/00082 , A61B1/00165 , A61B1/00186 , A61B1/042 , A61B1/043 , A61B1/05 , A61B1/06 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B1/0676 , A61B1/0684 , A61B5/0084 , A61B5/14546 , A61B5/1459 , A61B5/4848 , A61B5/6853 , A61B5/742 , A61B18/00 , A61B18/02 , A61B18/1492 , A61B2018/00357 , A61B2018/00577 , A61B2018/00982
摘要： Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue includes a catheter having an expandable balloon at a distal end, an illumination device positioned within the balloon for propagating light from an external light source for illuminating a tissue being treated to excite native nicotinamide adenine dinucleotide hydrogen (NADH) in the tissue, and an imaging device positioned within the balloon for detecting fluorescence from the illuminated tissue, the imaging device being configured to communicate detected NADH fluorescence to an external fluorescence camera.
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公开(公告)号：EP3215002A4
公开(公告)日：2018-08-01
申请号：EP15857544
申请日：2015-11-03
发明人： AMIRANA OMAR , ARMSTRONG KENNETH C , BOWEN JAMES H , LARSON CINNAMON , MERCADER MARCO A , RANSBURY TERRANCE J , SARVAZYAN NARINE
CPC分类号： A61B18/1492 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/062 , A61B5/4836 , A61B5/6843 , A61B18/1206 , A61B90/37 , A61B2018/00029 , A61B2018/00351 , A61B2018/00577 , A61B2018/00642 , A61B2018/00702 , A61B2018/00708 , A61B2018/00875 , A61B2018/00898 , A61B2018/00904 , A61B2018/00982 , A61B2018/00994 , A61B2218/002
摘要： Ablation visualization and monitoring systems and methods are provided. In some embodiments, such methods comprise applying ablation energy to a tissue to form a lesion in the tissue, illuminating the tissue with a light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both, monitoring a level of NADH fluorescence in the illuminated tissue to determine when the level of NADH fluorescence decreases from a base level in the beginning of the ablating to a predetermined lower level, and stopping ablation of the tissue when the level of NADH fluorescence reaches the predetermined lower level.
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公开(公告)号：EP3223735A4
公开(公告)日：2018-07-11
申请号：EP15863645
申请日：2015-11-25
申请人： LUXCATH LLC
IPC分类号： A61B18/00 , A61B18/02 , A61B18/06 , A61B18/08 , A61B18/12 , A61B18/14 , A61B18/18 , A61B18/24
CPC分类号： A61B1/3137 , A61B1/00082 , A61B1/042 , A61B1/043 , A61B1/05 , A61B1/07 , A61B5/0071 , A61B8/0841 , A61B8/085 , A61B8/12 , A61B18/02 , A61B18/06 , A61B18/082 , A61B18/1492 , A61B18/245 , A61B2018/00232 , A61B2018/00357 , A61B2018/00375 , A61B2018/00577 , A61B2018/00779 , A61B2018/00994 , A61B2018/0212 , A61B2018/1861
摘要： Methods and systems for ablation mapping and ablation procedures are provided. In some embodiments, a catheter for visualizing ablated tissue comprises a catheter body; a support assembly extending past a distal end of the catheter body, the support assembly having a lumen therethrough; and a balloon having a proximal end and a distal end, wherein the proximal end of the balloon is attached to the catheter body and the distal end of the balloon is attached to the support assembly, the balloon having an opening at the distal end in alignment with the lumen of the support assembly to provide a continuous path from the catheter body to outside of the balloon.
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5.发明公开SYSTEMS AND METHODS FOR DETERMINING LESION DEPTH USING FLUORESCENCE IMAGING 审中-公开SYSTEME UND VERFAHREN ZUR BESTIMMUNG EINERLÄSIONSTIEFEDURCH FLUORESZENZBILDGEBUNG
公开(公告)号：EP3068288A4
公开(公告)日：2017-07-26
申请号：EP14861958
申请日：2014-11-14
CPC分类号： A61B5/0071 , A61B5/0044 , A61B5/0084 , A61B5/4836 , A61B18/02 , A61B18/12 , A61B2018/00351
摘要： Systems, catheter and methods for treating Atrial Fibrillation (AF) are provided, which are configured to illuminate a heart tissue having a lesion site; obtain a mitochondrial nicotinamide adenine dinucleotide hydrogen (NADH) fluorescence intensity from the illuminated heart tissue along a first line across the lesion site; create a 2-dimensional (2D) map of the depth of the lesion site along the first line based on the NADH fluorescence intensity; and determine a depth of the lesion site at a selected point along the first line from the 2D map, wherein a lower NADH fluorescence intensity corresponds to a greater depth in the lesion site and a higher NADH fluorescence intensity corresponds to an unablated tissue. The process may be repeated to create a 3 dimensional map of the depth of the lesion.
摘要翻译： 提供了用于治疗心房颤动（AF）的系统，导管和方法，其被配置为照射具有病变部位的心脏组织; 沿穿过病变部位的第一条线从照射的心脏组织获得线粒体烟酰胺腺嘌呤二核苷酸氢（NADH）荧光强度; 基于NADH荧光强度沿着第一条线创建病变部位深度的二维（2D）图; 并且从2D图确定在沿着第一条线的选定点处的损伤部位的深度，其中较低的NADH荧光强度对应于损伤部位中的较大深度并且较高的NADH荧光强度对应于未消融的组织。 该过程可以重复以创建病变深度的三维图。
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