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公开(公告)号：EP2562248A1
公开(公告)日：2013-02-27
申请号：EP12172814.1
申请日：2008-07-18
申请人： Lifescan, Inc.
发明人： Rezania, Alireza
IPC分类号： C12N5/0735
CPC分类号： C12N5/0676 , C12N5/0606 , C12N5/067 , C12N5/0678 , C12N2501/115 , C12N2501/119 , C12N2501/155 , C12N2501/16 , C12N2501/23 , C12N2501/385 , C12N2501/415 , C12N2501/70 , C12N2502/13 , C12N2506/02 , C12N2533/52 , C12N2533/90
摘要： The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.
摘要翻译： 本发明提供了促进多能干细胞分化的方法。 特别地，本发明提供了用于形成胰腺内胚层，胰腺激素表达细胞和胰腺激素分泌细胞的改进方法。 本发明还提供了在不使用饲养细胞层的情况下促进多能干细胞分化的方法。
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公开(公告)号：EP1811019A1
公开(公告)日：2007-07-25
申请号：EP06256402.6
申请日：2006-12-15
申请人： LifeScan, Inc.
发明人： Rezania, Alireza , Ghabrial, Ragae
CPC分类号： C12N5/0068 , C12N2533/40
摘要： The present invention generally relates to a method for seeding cells on to a support. In particular, the method relates to a method for seeding cells onto a porous hydrophobic support. The method utilizes centrifugal forces to uniformly guide cell seeding into the support with no loss in viability.
摘要翻译： 本发明一般涉及将细胞接种到支持体上的方法。 特别地，该方法涉及将细胞接种到多孔疏水性载体上的方法。 该方法利用离心力均匀地引导细胞播种到支持体中，而不损失生存力。
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3.发明公开Compositions and methods to create a vascularized environment for cellular transplantation 审中-公开组合物和方法用于制备血管环境的细胞移植
公开(公告)号：EP1676591A2
公开(公告)日：2006-07-05
申请号：EP05257209.6
申请日：2005-11-23
申请人： LifeScan, Inc.
发明人： Rezania, Alireza , Xu, Jean , Ghabrial, Ragae
CPC分类号： A61L27/54 , A61L27/36 , A61L27/38 , A61L27/58 , A61L2300/252 , A61L2300/402 , A61L2300/41 , A61L2300/414 , A61L2300/604
摘要： The present invention generally relates to biocompatible devices suitable for increasing cellular HIF-1 α protein levels. In particular, the present invention relates to an implant comprising a biocompatible support loaded with at least one pharmaceutical agent capable of increasing cellular HIF-1 α protein levels to promote vascularization at or near the implant site. Vascularization of the implanted support results in enhanced survival of cells optionally incorporated within the support. Methods for treating a disease or injury via implanting the support of the present invention are also provided.
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4.发明授权
公开(公告)号：EP1676591B1
公开(公告)日：2018-08-01
申请号：EP05257209.6
申请日：2005-11-23
申请人： LifeScan, Inc.
发明人： Rezania, Alireza , Xu, Jean , Ghabrial, Ragae
CPC分类号： A61L27/54 , A61L27/36 , A61L27/38 , A61L27/58 , A61L2300/252 , A61L2300/402 , A61L2300/41 , A61L2300/414 , A61L2300/604
摘要： The present invention generally relates to biocompatible devices suitable for increasing cellular HIF-1 ± protein levels. In particular, the present invention relates to an implant comprising a biocompatible support loaded with at least one pharmaceutical agent capable of increasing cellular HIF-1 ± protein levels to promote vascularization at or near the implant site. Vascularization of the implanted support results in enhanced survival of cells optionally incorporated within the support. Methods for treating a disease or injury via implanting the support of the present invention are also provided.
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公开(公告)号：EP2287289A1
公开(公告)日：2011-02-23
申请号：EP10179724.9
申请日：2006-12-15
申请人： Lifescan, Inc.
发明人： Rezania, Alireza , Ghabrial, Ragae
IPC分类号： C12N5/071
CPC分类号： C12N5/0068 , C12N2533/40
摘要： The present invention generally relates to a method for seeding cells on to a support. In particular, the method relates to a method for seeding cells onto a porous hydrophobic support. The method utilizes centrifugal forces to uniformly guide cell seeding into the support with no loss in viability.
摘要翻译： 本发明一般涉及将细胞接种到支持物上的方法。 特别地，该方法涉及将细胞接种到多孔疏水支撑物上的方法。 该方法利用离心力均匀地引导细胞接种到支持体中而不丧失活力。
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公开(公告)号：EP1743663A3
公开(公告)日：2007-09-19
申请号：EP06253374.0
申请日：2006-06-28
申请人： LifeScan, Inc.
发明人： Ghabrial, Ragae , Fung, Ramie , Rezania, Alireza , Davis, Janet
CPC分类号： A61L27/38 , A61K35/44 , A61K38/1866 , A61L27/40 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61K2300/00
摘要： This invention provides devices designed to effectively deliver multiple biological entities in combination for tissue engineering. In particular, the present invention provides devices capable of delivering cells or clusters of cells, such as islets of Langerhans, in combination with a therapeutic compound, such as an angiogenic growth factor, for the purpose of transplantation. The devices of the present invention are composed of at least two compartments that are designed independently and processed separately in order to accommodate different requirements of the biological entities. The compartments of the present device can be combined prior to or at the time of implantation, such that the therapeutic released from one compartment provides some benefit to cells hosted by another compartment to promote or improve their proliferation, differentiation, survival, or functionality.
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公开(公告)号：EP1743663A2
公开(公告)日：2007-01-17
申请号：EP06253374.0
申请日：2006-06-28
申请人： LifeScan, Inc.
发明人： Ghabrial, Ragae , Fung, Ramie , Rezania, Alireza , Davis, Janet
CPC分类号： A61L27/38 , A61K35/44 , A61K38/1866 , A61L27/40 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61K2300/00
摘要： This invention provides devices designed to effectively deliver multiple biological entities in combination for tissue engineering. In particular, the present invention provides devices capable of delivering cells or clusters of cells, such as islets of Langerhans, in combination with a therapeutic compound, such as an angiogenic growth factor, for the purpose of transplantation. The devices of the present invention are composed of at least two compartments that are designed independently and processed separately in order to accommodate different requirements of the biological entities. The compartments of the present device can be combined prior to or at the time of implantation, such that the therapeutic released from one compartment provides some benefit to cells hosted by another compartment to promote or improve their proliferation, differentiation, survival, or functionality.
摘要翻译： 本发明提供设计成有效地将多个生物实体组合用于组织工程的装置。 特别地，本发明提供了能够将诸如胰岛的细胞或簇的细胞与治疗化合物如血管生成生长因子结合用于移植目的的装置。 本发明的装置由独立设计和分开设计的至少两个隔室组成，以适应生物实体的不同要求。 本装置的隔室可以在植入之前或在植入时组合，使得从一个隔室释放的治疗剂为由另一隔室托管的细胞提供一些益处以促进或改善其增殖，分化，存活或功能。
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公开(公告)号：EP1780267A2
公开(公告)日：2007-05-02
申请号：EP06252751.0
申请日：2006-05-26
申请人： LifeScan, Inc.
发明人： Rezania, Alireza , Xu, Jean
IPC分类号： C12N5/08
CPC分类号： C12N5/0605 , C12N2500/02 , C12N2533/52 , C12N2533/54
摘要： This invention relates to an expandable population of amniotic fluid-derived cells that can be differentiated into a β-cell lineage. This invention also provides methods for isolating and expanding such amniotic fluid-derived cells, as well as related methods and compositions for utilizing such cells in the therapeutic treatment of diabetes.
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9.发明公开Implantable pouch seeded with insulin-producing cells to treat diabetes 审中-公开植入袋besiedlet与产生胰岛素的细胞治疗糖尿病
公开(公告)号：EP1466632A1
公开(公告)日：2004-10-13
申请号：EP04252017.1
申请日：2004-04-02
申请人： Lifescan, Inc.
摘要： An implantable pouch and methods for implanting cells or cellular matter in mammals, comprising reinforced porous foam and a lumen. The lumen contains an insert that may or may not be removed prior to transplantation. The lumen may be loaded with at least one cell type expressing at least one transcription factor characteristic of a mammalian pancreatic beta cell.
摘要翻译： 用于植入的细胞或细胞物质在哺乳动物中可植入的袋和方法，其包括增强的多孔泡沫和内腔。 卷中包含插入件确实可以或可以不被移植前除去。 内腔可以与至少一种细胞类型表达的哺乳动物的胰腺β细胞中的至少一个转录因子特性被下载。
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公开(公告)号：EP1780267B1
公开(公告)日：2016-01-13
申请号：EP06252751.0
申请日：2006-05-26
申请人： LifeScan, Inc.
发明人： Rezania, Alireza , Xu, Jean
IPC分类号： C12N5/073
CPC分类号： C12N5/0605 , C12N2500/02 , C12N2533/52 , C12N2533/54
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