公开(公告)号：EP1642881A4

公开(公告)日：2007-07-18

申请号：EP04747165

申请日：2004-07-01

申请人： MITSUBISHI GAS CHEMICAL CO

发明人： YOSHIMURA T ,  HIDAKA T ,  SATO Y ,  FUSHIMI N ,  YAMADA KAZUHIRO

IPC分类号： C07C51/363 ,  C07C63/70

CPC分类号： C07C51/363 ,  C07C63/70

摘要： A process for producing 5-iodo-2-methylbenzoic acid by iodizing 2-methylbenzoic acid, which comprises, as essential steps, a reaction step in which 2-methylbenzoic acid is iodized in the presence of a microporous compound, iodine, an oxidizing agent, and acetic anhydride and a purification step in which sublimation, distillation, crystallization, or a combination of two or more of these is conducted. By the process, 5-iodo-2-methylbenzoic acid, which is useful in functional chemicals such as medicines, can be easily obtained as a high-purity compound in a high yield. The production steps comprising reaction and separation/purification are simple from the standpoint of process operation and the purification load is small. Furthermore, the microporous compound, e.g., a zeolite catalyst, separated and recovered from the liquid resulting from the reaction can be repeatedly used after a simple treatment. Consequently, the catalyst has a long life and the target compound can be produced by the efficient process.

公开(公告)号：EP1500641A4

公开(公告)日：2006-05-31

申请号：EP03723191

申请日：2003-04-24

申请人： MITSUBISHI GAS CHEMICAL CO

发明人： HIDAKA T ,  FUSHIMI N ,  YOSHIMURA T ,  KAWAI T

IPC分类号： C07C29/136 ,  C07B39/00 ,  C07B61/00 ,  C07C29/147 ,  C07C29/62 ,  C07C33/46 ,  C07C37/56 ,  C07C39/24 ,  C07C45/41 ,  C07C45/45 ,  C07C45/63 ,  C07C45/67 ,  C07C47/55 ,  C07C49/80 ,  C07C51/04 ,  C07C51/363 ,  C07C51/62 ,  C07C63/70 ,  C07C67/14 ,  C07C67/307 ,  C07C69/76 ,  C07C209/26 ,  C07C211/29 ,  C07C231/02 ,  C07C233/65 ,  C07C253/20 ,  C07C255/49 ,  C07C255/50 ,  C07C37/62 ,  C07C63/72 ,  C07C209/68 ,  C07C211/52 ,  C07C231/12 ,  C07C253/30

CPC分类号： C07C45/41 ,  C07B39/00 ,  C07C29/147 ,  C07C39/24 ,  C07C45/45 ,  C07C45/63 ,  C07C47/55 ,  C07C49/80 ,  C07C51/04 ,  C07C51/62 ,  C07C67/307 ,  C07C211/29 ,  C07C233/65 ,  C07C255/50 ,  C07C63/72 ,  C07C63/70 ,  C07C69/76 ,  C07C33/46

摘要： The process for producing a (fluoroalkyl)benzene derivative according to the present invention comprises a step of reducing the total content of group 3 to group 12 transition metals in an alkylbenzene derivative to 500 ppm or less in terms of metal atoms; a step of halogenating the branched alkyl group of the purified alkylbenzene derivative by a photohalogenation to obtain a (haloalkyl)benzene derivative; and a step of subjecting the (haloalkyl)benzene derivative to a halogen-fluorine exchange using HF in an amount of 10 mol or higher per one mole of the (haloalkyl)benzene derivative. The (fluoroalkyl)benzene derivative produced by the process is reduced in the content of impurities such as residual halogens and residual metals, and is useful as intermediates for functional chemical products for use in applications such as medicines and electronic materials.

摘要翻译： 本发明的（氟代烷基）苯衍生物的制造方法包括使烷基苯衍生物中的第1族过渡金属的组3的含量以金属原子计降低至500ppm以下的步骤; 通过光卤代化将纯化的烷基苯衍生物的支链烷基卤化以获得（卤代烷基）苯衍生物的步骤; 以及使用每10摩尔（卤代烷基）苯衍生物的10摩尔以上的量使用（卤代烷基）苯衍生物进行卤代氟交换的工序。 通过该方法制备的（氟代烷基）苯衍生物的残留卤素和残余金属等杂质含量降低，可用作药物和电子材料等应用中的功能性化学产品的中间体。