公开(公告)号：EP3368085A1

公开(公告)日：2018-09-05

申请号：EP16805919.4

申请日：2016-11-01

申请人： Massachusetts Institute Of Technology ,  The Children's Medical Center Corporation

发明人： VEGAS, Arturo, Jose ,  DOLOFF, Joshua, Charles ,  VEISEH, Omid ,  MA, Minglin ,  LANGER, Robert, S. ,  ANDERSON, Daniel, G.

IPC分类号： A61K47/36 ,  C08B37/00 ,  C12N5/00

CPC分类号： A61L29/085 ,  A61K9/0024 ,  A61K9/4816 ,  A61K9/5036 ,  A61K35/39 ,  A61K47/36 ,  A61L31/10 ,  A61L33/08 ,  C07D487/04 ,  C08B37/0084 ,  C12N5/0012 ,  C12N5/0677

摘要： Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.

公开(公告)号：EP3368596A1

公开(公告)日：2018-09-05

申请号：EP16816769.0

申请日：2016-11-01

申请人： Massachusetts Institute Of Technology ,  Children's Medical Center Corporation

发明人： VEGAS, Arturo, Jose ,  DOLOFF, Joshua, Charles ,  VEISEH, Omid ,  LANGER, Robert, S. ,  ANDERSON, Daniel, G.

IPC分类号： C08J7/12

CPC分类号： A61L27/3804 ,  A61K9/0051 ,  A61K35/12 ,  A61K35/36 ,  A61K38/02 ,  A61L27/04 ,  A61L27/10 ,  A61L27/16 ,  A61L27/18 ,  A61L27/20 ,  A61L27/34 ,  A61L27/3813 ,  A61L27/3839 ,  A61L27/54 ,  A61L27/56 ,  A61L29/14 ,  A61L2300/252 ,  A61L2300/254 ,  A61L2400/18 ,  C08J7/12

摘要： Products, such as devices, prostheses, and materials, whose surfaces have been modified in order to impart beneficial properties to these products are disclosed. The surface-modified products have improved biocompatibility compared to a corresponding product that lacks the modification. Following implantation in a subject, the surface-modified products induce a lower foreign-body response, compared to a corresponding unmodified product.

公开(公告)号：EP3297693A1

公开(公告)日：2018-03-28

申请号：EP16730071.4

申请日：2016-05-17

申请人： Massachusetts Institute of Technology ,  The Children's Medical Center Corporation

发明人： MA, Minglin ,  ANDERSON, Daniel, G. ,  LANGER, Robert, S. ,  VEISEH, Omid ,  VEGAS, Arturo, Jose ,  DOLOFF, Joshua, Charles ,  CHEN, Delai ,  KASTRUP, Christian, J.

IPC分类号： A61L27/20 ,  A61L27/38 ,  A61L27/52 ,  A61L27/54

CPC分类号： A61L27/20 ,  A61F2/02 ,  A61F2230/0071 ,  A61F2240/001 ,  A61F2250/0068 ,  A61L27/3804 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/64 ,  A61L2400/18 ,  A61M31/002 ,  A61M2205/04 ,  A61M2207/00

摘要： Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.

公开(公告)号：EP2791210A1

公开(公告)日：2014-10-22

申请号：EP12809954.6

申请日：2012-12-15

申请人： Massachusetts Institute of Technology

发明人： VEGAS, Arturo, Jose ,  WHITEHEAD, Kathryn, Ann ,  ANDERSON, Daniel, Griffith ,  LANGER, Robert, S. ,  DORKIN, Joseph, R.

IPC分类号： C08G73/00 ,  C08L79/00 ,  A61K9/127 ,  A61K47/34 ,  A61K9/51 ,  C12N15/88

CPC分类号： A61K47/34 ,  A61K9/1271 ,  A61K9/5146 ,  A61K31/713 ,  A61K33/00 ,  A61K38/16 ,  A61K39/00 ,  C08G12/06 ,  C08G12/34 ,  C08G73/00 ,  C08L79/00 ,  C12N15/113

摘要： α-Aminoamidine polymers and methods of preparing a-aminoamidine polymers by reacting by reacting one or more amines with one or more isocyanides and one or more aldehydes are described. Methods of preparing a-aminoamidine polymers from commercially available starting materials are also provided, wherein the starting materials are racemic or stereochemically pure. a-Aminoamidine polymers or salt forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems and for other purposes as well such as, for example, coatings, additives, excipients, plastics, and materials, etc. Given the amino moiety of these α-aminoamidine polymers, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive α-aminoamidine polymers and polynucleotides can be prepared. The inventive α-aminoamidine polymers may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

摘要翻译： 描述了α-氨基脒聚合物和通过使一种或多种胺与一种或多种异氰化物和一种或多种醛反应来制备α-氨基脒聚合物的方法。 还提供了由市售原料制备α-氨基脒聚合物的方法，其中原料是外消旋或立体化学纯的。 α-氨基脒聚合物或其盐形式优选是可生物降解的和生物相容的，并且可以用于多种药物递送系统中以及用于其他目的，例如涂料，添加剂，赋形剂，塑料和材料等。给定的 这些α-氨基脒聚合物的氨基部分，它们特别适合于递送多核苷酸。 可以制备含有本发明的α-氨基脒聚合物和多核苷酸的复合物，胶束，脂质体或颗粒。 本发明的α-氨基脒聚合物也可以用于制备用于药物递送的微粒。 考虑到它们缓冲周围环境pH的能力，它们在提供不稳定剂方面特别有用。

公开(公告)号：EP2771319A1

公开(公告)日：2014-09-03

申请号：EP12783791.2

申请日：2012-10-26

申请人： Massachusetts Institute Of Technology

发明人： DONG, Yizhou ,  LOVE, Kevin, Thomas ,  LANGER, Robert, S. ,  ANDERSON, Daniel, Griffith ,  CHEN, Delai ,  CHEN, Yi ,  VEGAS, Arturo, Jose ,  ALABI, Akinleye ,  ZHANG, Yunlong

IPC分类号： C07D207/16 ,  C07D209/20 ,  C07D233/64 ,  C07D241/08 ,  C07D403/06 ,  C07D487/06 ,  C07C227/18 ,  C07C229/12 ,  C07C229/16 ,  C07C229/22 ,  C07C229/26 ,  C07C229/28 ,  A61K48/00 ,  C12N15/87

CPC分类号： A61K31/7105 ,  A61K31/711 ,  A61K47/22 ,  A61K2121/00 ,  C07C229/12 ,  C07C229/22 ,  C07C229/24 ,  C07C229/26 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C07C271/22 ,  C07C279/14 ,  C07C323/58 ,  C07D207/16 ,  C07D209/20 ,  C07D209/24 ,  C07D233/64 ,  C07D241/08 ,  C07D265/32 ,  C07D403/06 ,  C07D413/06 ,  C07D487/04 ,  C07D487/06 ,  C12N15/87 ,  C12N15/88 ,  C12Q1/025 ,  G01N33/15

摘要： Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as "APPLs". Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R', R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

摘要翻译： worin M，N，P，R”，R1，R2，R3，R4，R5，R8，Z，W，Y，和Z如在定义。

公开(公告)号：EP2968115A1

公开(公告)日：2016-01-20

申请号：EP14718289.3

申请日：2014-03-14

申请人： Massachusetts Institute of Technology

发明人： MA, Minglin ,  ANDERSON, Daniel, G. ,  LANGER, Robert,S. ,  VEISEH, Omid ,  VEGAS, Arturo, Jose ,  DOLOFF, Joshua, Charles

IPC分类号： A61K9/00 ,  A61K9/68 ,  A61K9/50 ,  A61K35/39

CPC分类号： A61K35/39 ,  A61K9/0024 ,  A61K9/5036 ,  A61K9/5078 ,  A61K9/5089 ,  A61K2035/126 ,  A61K2035/128 ,  B01J13/046

摘要： Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.

摘要翻译： 公开了包封直径大于1mm的哺乳动物细胞和任选的无细胞核的生物相容性水凝胶胶囊，其在植入受试者后具有减少的纤维化过度生长。 还公开了治疗受试者疾病的方法，其涉及向受试者施用治疗有效量的所公开的封闭细胞。

公开(公告)号：EP2882706A1

公开(公告)日：2015-06-17

申请号：EP13751043.4

申请日：2013-08-13

申请人： Massachusetts Institute of Technology

发明人： ANDERSON, Daniel, Griffith ,  WHITEHEAD, Kathryn, Ann ,  DORKIN, Joseph, R. ,  VEGAS, Arturo, Jose ,  ZHANG, Yunlong ,  LANGER, Robert, S.

IPC分类号： C07C229/12 ,  C07C229/14 ,  C07D295/13 ,  C07D211/14 ,  C07D319/18 ,  C07D207/09 ,  C07D211/26 ,  C07D487/04 ,  A61K47/18 ,  A61K9/127 ,  A61K9/51 ,  A61K31/496 ,  C12N15/11 ,  C12N15/88

CPC分类号： A61K47/22 ,  A61K9/1272 ,  A61K9/5123 ,  A61K31/225 ,  A61K31/357 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495 ,  A61K31/4985 ,  A61K31/573 ,  A61K31/704 ,  A61K31/713 ,  A61K45/06 ,  A61K47/18 ,  A61K47/542 ,  A61K47/543 ,  A61K47/6925 ,  C07C225/06 ,  C07C229/12 ,  C07C229/14 ,  C07C229/24 ,  C07C229/26 ,  C07C229/28 ,  C07C229/34 ,  C07C2601/14 ,  C07D207/09 ,  C07D211/14 ,  C07D211/26 ,  C07D211/34 ,  C07D241/04 ,  C07D295/13 ,  C07D295/15 ,  C07D295/16 ,  C07D319/16 ,  C07D319/18 ,  C07D487/04 ,  C12N15/111 ,  C12N15/1137 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  A61K2300/00

摘要： Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are biodegradable and may be used in a variety of drug delivery systems. Given the amino moiety of the lipidoids, they are well-suited for the delivery of polynucleotides, in addition to other agents. Nanoparticles containing the inventive lipidoids and polynucleotides have been prepared and have been shown to be effective in delivering siRNA.

摘要翻译： 本文提供的是可以通过将烷基胺偶联加成丙烯酸酯制备的类脂。 在一些实施方案中，提供的类脂质是可生物降解的并且可以用于多种药物递送系统中。 考虑到类固醇的氨基部分，除了其它药剂之外，它们非常适合于递送多核苷酸。 已经制备了含有本发明的类脂和多核苷酸的纳米颗粒，并已显示其有效递送siRNA。