-
公开(公告)号：EP3368596A1
公开(公告)日：2018-09-05
申请号：EP16816769.0
申请日：2016-11-01
发明人： VEGAS, Arturo, Jose , DOLOFF, Joshua, Charles , VEISEH, Omid , LANGER, Robert, S. , ANDERSON, Daniel, G.
IPC分类号： C08J7/12
CPC分类号： A61L27/3804 , A61K9/0051 , A61K35/12 , A61K35/36 , A61K38/02 , A61L27/04 , A61L27/10 , A61L27/16 , A61L27/18 , A61L27/20 , A61L27/34 , A61L27/3813 , A61L27/3839 , A61L27/54 , A61L27/56 , A61L29/14 , A61L2300/252 , A61L2300/254 , A61L2400/18 , C08J7/12
摘要： Products, such as devices, prostheses, and materials, whose surfaces have been modified in order to impart beneficial properties to these products are disclosed. The surface-modified products have improved biocompatibility compared to a corresponding product that lacks the modification. Following implantation in a subject, the surface-modified products induce a lower foreign-body response, compared to a corresponding unmodified product.
-
公开(公告)号：EP3174906A1
公开(公告)日：2017-06-07
申请号：EP15750880.5
申请日：2015-08-03
发明人： VEGAS, Arturo J. , DOLOFF, Joshua C. , VEISEH, Omid , MA, Minglin , LANGER, Robert S. , ANDERSON, Daniel G.
CPC分类号： A61K9/5036 , A61K9/0024 , A61K35/39 , A61L29/085 , A61L31/10 , A61L33/08 , C08B37/0084 , C12N5/0012 , C12N5/0677 , C08L5/04
摘要： Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.
摘要翻译： 本文公开了具有增强的生物相容性和定制的理化性质的共价改性的藻酸盐聚合物，以及其制备和使用方法。 共价修饰的藻酸盐可用作涂覆任何需要减少纤维化的材料的基质，例如用于移植的包封细胞和植入或用于体内的医疗装置。
-
3.发明公开
公开(公告)号：EP3469008A1
公开(公告)日：2019-04-17
申请号：EP17739397.2
申请日：2017-06-13
-
公开(公告)号：EP3368085A1
公开(公告)日：2018-09-05
申请号：EP16805919.4
申请日：2016-11-01
发明人： VEGAS, Arturo, Jose , DOLOFF, Joshua, Charles , VEISEH, Omid , MA, Minglin , LANGER, Robert, S. , ANDERSON, Daniel, G.
CPC分类号： A61L29/085 , A61K9/0024 , A61K9/4816 , A61K9/5036 , A61K35/39 , A61K47/36 , A61L31/10 , A61L33/08 , C07D487/04 , C08B37/0084 , C12N5/0012 , C12N5/0677
摘要： Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.
-
公开(公告)号：EP3468633A1
公开(公告)日：2019-04-17
申请号：EP17734567.5
申请日：2017-06-13
发明人： DOLOFF, Joshua , XIE, Xi , YESILYURT, Volkan , VEISEH, Omid , SADRAEI, Atieh , ANDERSON, Daniel, G. , LANGER, Robert, S.
IPC分类号： A61L31/10 , A61B5/145 , A61B5/1486
-
6.发明公开MULTI-LAYER HYDROGEL CAPSULES FOR ENCAPSULATION OF CELLS AND CELL AGGREGATES 审中-公开用于细胞和细胞融合的多层水凝胶胶囊
公开(公告)号：EP3297693A1
公开(公告)日：2018-03-28
申请号：EP16730071.4
申请日：2016-05-17
发明人： MA, Minglin , ANDERSON, Daniel, G. , LANGER, Robert, S. , VEISEH, Omid , VEGAS, Arturo, Jose , DOLOFF, Joshua, Charles , CHEN, Delai , KASTRUP, Christian, J.
CPC分类号： A61L27/20 , A61F2/02 , A61F2230/0071 , A61F2240/001 , A61F2250/0068 , A61L27/3804 , A61L27/52 , A61L27/54 , A61L2300/64 , A61L2400/18 , A61M31/002 , A61M2205/04 , A61M2207/00
摘要： Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
-
7.发明公开MULTI-LAYER HYDROGEL CAPSULES FOR ENCAPSULATION OF CELLS AND CELL AGGREGATES 审中-公开维多利亚州维多利亚州VERKAPSELUNG VEN ZELLEN UNDZELLVERBÄNDEN
公开(公告)号：EP2968115A1
公开(公告)日：2016-01-20
申请号：EP14718289.3
申请日：2014-03-14
发明人： MA, Minglin , ANDERSON, Daniel, G. , LANGER, Robert,S. , VEISEH, Omid , VEGAS, Arturo, Jose , DOLOFF, Joshua, Charles
CPC分类号： A61K35/39 , A61K9/0024 , A61K9/5036 , A61K9/5078 , A61K9/5089 , A61K2035/126 , A61K2035/128 , B01J13/046
摘要： Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
摘要翻译： 公开了包封直径大于1mm的哺乳动物细胞和任选的无细胞核的生物相容性水凝胶胶囊，其在植入受试者后具有减少的纤维化过度生长。 还公开了治疗受试者疾病的方法，其涉及向受试者施用治疗有效量的所公开的封闭细胞。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.022 秒)
