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    VACCINE NANOTECHNOLOGY
    9.
    发明公开
    VACCINE NANOTECHNOLOGY 有权
    VAKZINE-NANOTECHNOLOGIE

    公开(公告)号：EP2217269A2

    公开(公告)日：2010-08-18

    申请号：EP08839738.5

    申请日：2008-10-12

    申请人： Massachusetts Institute of Technology

    发明人： VON ANDRIAN, Ulrich, H. ,  FAROKHZAD, Omid, C. ,  LANGER, Robert, S. ,  JUNT, Tobias ,  MOSEMAN, Ashley ,  ZHANG, Liangfang ,  BASTO, Pamela ,  IANNACONE, Matteo ,  ALEXIS, Frank

    IPC分类号： A61K39/00

    CPC分类号： A61K9/14 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/39 ,  A61K47/6911 ,  A61K47/6937 ,  A61K2039/555 ,  A61K2039/60 ,  Y02A50/464 ,  Y02A50/472

    摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one vaccine nanocarrier to a subject in need thereof.

    摘要翻译： 本发明提供了用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的疫苗纳米载体，在一些实施方案中，包含至少一种免疫调节剂，并且任选地包含至少一种靶向部分和任选的至少一种免疫刺激剂。 本发明提供包含疫苗纳米载体的药物组合物。 本发明提供了疫苗纳米载体的设计，制造和使用方法及其药物组合物。 本发明提供了预防和/或治疗疾病，病症和病症的方法，包括向有需要的受试者施用至少一种疫苗纳米载体。

    POLYMERS FOR FUNCTIONAL PARTICLES
    10.
    发明公开
    POLYMERS FOR FUNCTIONAL PARTICLES 审中-公开
    POLYMEREFÜRFUNKTIONELLE PARTIKEL

    公开(公告)号：EP2019691A2

    公开(公告)日：2009-02-04

    申请号：EP07794944.4

    申请日：2007-05-15

    申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    发明人： GU, Frank, X. ,  TEPLY, Benjamin, A. ,  LANGER, Robert, S. ,  FAROKHZAD, Omid, C.

    IPC分类号： A61K47/48

    摘要： The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other aspects of the invention are directed to methods using such libraries, methods of using or administering such polymeric conjugates, methods of promoting the use of such polymeric conjugates, kits involving such polymeric conjugates, or the like.

    摘要翻译： 一种方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或更多种不同比例的大分子混合在一起形成。 一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。 纳米颗粒可以含有药物。 该部分可以包括多肽或多核苷酸，例如适体。 该部分可以是靶向部分，成像部分，螯合部分，带电部分或治疗部分。 另一方面涉及制备这种聚合物共轭物的体系和方法。 在一些实施方案中，将含有聚合物的溶液与液体（例如不混溶液体）接触以形成含有聚合物缀合物的纳米颗粒。 其他方法使用这种文库，使用或施用这种聚合物缀合物，或促进使用这种聚合物缀合物。 还描述了涉及这种聚合物共轭物的试剂盒。