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1.发明公开COMBINATIONS OF LOW, IMMUNE ENHANCING. DOSES OF MTOR INHIBITORS AND CARS 审中-公开低，免疫增强的组合。 MTOR抑制剂和汽车的剂量
公开(公告)号：EP3193915A1
公开(公告)日：2017-07-26
申请号：EP15753232.6
申请日：2015-07-21
IPC分类号： A61K39/00 , A61K31/4745
CPC分类号： A61K45/06 , A61K31/436 , A61K31/4745 , A61K31/5377 , A61K39/00 , A61K2039/55511 , A61K2300/00
摘要： The invention relates, in part, to a method of treating a subject comprising administering to the subject a low, immune enhancing of a mTOR inhibitor and an immune effector cell engineered to expres a CAR.
摘要翻译： 本发明部分涉及治疗受试者的方法，其包括向受试者施用mTOR抑制剂和工程化表达CAR的免疫效应细胞的低免疫增强。
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公开(公告)号：EP3717907A1
公开(公告)日：2020-10-07
申请号：EP18833128.4
申请日：2018-11-30
发明人： PRUTEANU-MALINICI, Iulian , MANSFIELD, Keith , ENGELS, Boris , MELENHORST, Jan, J. , COHEN, Adam, David , STADTMAUER, Edward, A. , GARFALL, Alfred , MILONE, Michael, C. , FRAIETTA, Joseph, A.
IPC分类号： G01N33/50 , G01N33/574
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3.发明公开
公开(公告)号：EP3615055A1
公开(公告)日：2020-03-04
申请号：EP18727094.7
申请日：2018-04-27
IPC分类号： A61K38/17 , A61K35/17 , C07K14/725 , C07K16/28 , C12N5/0783
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4.发明公开
公开(公告)号：EP4234685A3
公开(公告)日：2023-09-06
申请号：EP23159683.4
申请日：2016-04-15
发明人： BARRETT, David, Maxwell , BEDOYA, Filipe , GHASSEMI, Saba , JUNE, Carl, H. , LEVINE, Bruce, L. , MELENHORST, Jan, J. , MILONE, Michael, C. , POWELL, Daniel, J. , SINGH, Nathan, Amar , ZHENG, Zoe
IPC分类号： C12N5/0783 , C07K14/47 , C07K14/705 , C12N5/00 , A61K35/17
摘要： The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.
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公开(公告)号：EP3953455A1
公开(公告)日：2022-02-16
申请号：EP20722937.8
申请日：2020-04-10
IPC分类号： C12N5/0783 , A61K35/17
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公开(公告)号：EP3325504A1
公开(公告)日：2018-05-30
申请号：EP16750306.9
申请日：2016-07-21
发明人： BEDOYA, Felipe , GHASSEMI, Saba , JUNE, Carl, H. , KAWALEKAR, Omkar, U. , LEVINE, Bruce, L. , MELENHORST, Jan, J. , MILONE, Michael, C. , POWELL, Daniel, Jr., J. , ZHENG, Zoe
IPC分类号： C07K14/725 , C07K16/30 , A61K48/00
CPC分类号： C12N5/0636 , A61K35/17 , C07K14/7051 , C07K14/70517 , C07K14/70578 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/30 , C07K2317/622 , C07K2319/03 , C07K2319/33 , C07K2319/74 , C12N5/0087 , C12N2501/2302 , C12N2501/2307 , C12N2501/2315 , C12N2501/50 , C12N2510/00 , C12N2740/16043
摘要： The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.
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公开(公告)号：EP3240803A2
公开(公告)日：2017-11-08
申请号：EP15832850.0
申请日：2015-12-28
发明人： BEDOYA, Felipe , GHASSEMI, Saba , JUNE, Carl, H. , LEVINE, Bruce, L. , MELENHORST, Jan, J. , MILONE, Michael, C. , POWELL, Daniel, J., Jr. , ZHENG, Zoe
IPC分类号： C07K14/725 , C12N5/00 , C12N5/0783 , A61K39/00
CPC分类号： C07K16/2803 , A61K35/17 , A61K2039/5156 , A61K2039/5158 , C07K14/7051 , C07K14/70517 , C07K14/70578 , C07K16/28 , C07K2317/14 , C07K2317/622 , C07K2319/03 , C07K2319/74 , C12N5/0087 , C12N5/0636 , C12N5/0638 , C12N9/1276 , C12N2501/2302 , C12N2501/2307 , C12N2501/2315 , C12N2501/51 , C12N2501/515 , C12N2510/00 , C12Y207/07049
摘要： The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), and compositions and reaction mixtures comprising the same.
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8.发明公开
公开(公告)号：EP4234685A2
公开(公告)日：2023-08-30
申请号：EP23159683.4
申请日：2016-04-15
发明人： BARRETT, David, Maxwell , BEDOYA, Filipe , GHASSEMI, Saba , JUNE, Carl, H. , LEVINE, Bruce, L. , MELENHORST, Jan, J. , MILONE, Michael, C. , POWELL, Daniel, J. , SINGH, Nathan, Amar , ZHENG, Zoe
IPC分类号： C12N5/0783 , C07K14/47 , C07K14/705 , C12N5/00 , A61K35/17
摘要： The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.
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9.发明公开
公开(公告)号：EP3710040A1
公开(公告)日：2020-09-23
申请号：EP18816353.9
申请日：2018-11-15
发明人： GARFALL, Alfred , COHEN, Adam, David , MILONE, Michael, C. , PLESA, Gabriela , STADTMAUER, Edward, A. , JUNE, Carl, H.
IPC分类号： A61K38/17 , A61K35/17 , A61K31/675 , A61K31/7076 , A61P35/02
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公开(公告)号：EP3171882A1
公开(公告)日：2017-05-31
申请号：EP15744448.0
申请日：2015-07-21
发明人： KENDERIAN, Saad , BROGDON, Jennifer , EBERSBACH, Hilmar , GILL, Saar , GLASS, David , JASCUR, Julia , MANNICK, Joan , MILONE, Michael, C. , MURPHY, Leon , RICHARDSON, Celeste , SINGH, Reshma , WEI, Lai , WU, Qilong , YANG, Qiumei , ZHANG, Jiquan
IPC分类号： A61K35/17 , C07K14/725 , C07K16/28
CPC分类号： A61K39/0011 , A61K31/7068 , A61K35/17 , A61K45/06 , A61K2039/5156 , C07K14/7051 , C07K14/70578 , C07K16/2851 , C07K2317/622 , C07K2319/02 , C07K2319/03
摘要： The invention provides compositions and methods for treating diseases associated with expression of CLL-1. The invention also relates to chimeric antigen receptor (CAR) specific to CLL-1, vectors encoding the same, and recombinant cells comprising the CLL-1 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CLL-1 binding domain.
摘要翻译： 本发明提供了用于治疗与CLL-1表达相关的疾病的组合物和方法。 本发明还涉及对CLL-1特异性的嵌合抗原受体（CAR），编码它的载体和包含CLL-1 CAR的重组细胞。 本发明还包括施用表达包含CLL-1结合结构域的CAR的基因修饰细胞的方法。
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