-
公开(公告)号：EP0752889A1
公开(公告)日：1997-01-15
申请号：EP95913223.0
申请日：1995-03-27
发明人： KLAVENESS, Jo , BERG, Arne , JACOBSEN, Trond Vegard , RONGVED, Pal , EGE, Thorfinn , KIKUCHI, Hiroshi, Daiichi Pharmaceutical Co., Ltd. , YACHI, Kiyoto, Daiichi Pharmaceutical Co., Ltd.
CPC分类号： A61K49/227 , A61K49/0466 , A61K49/1812
摘要： The invention provides a diagnostic composition for administration to human or animal subjects the composition containing multilamellar liposomes, optionally together with unilamellar liposomes, the liposomes containing at least one imaging agent and being suspended in an aqueous medium containing said imaging agent, wherein the liposomes comprise a neutral phospholipid and a charged phospholipid, the average particle diameter of the liposomes is 50-3000 nm and the concentration of imaging agent in any aqueous phase filling the interior of the liposomes is substantially the same as that in the aqueous medium in which the liposomes are suspended. The contrast agents concerned are typically X-ray, MRI or ultrasound contrast agents.
摘要翻译： 本发明提供了用于给人或动物对象施用含有多层脂质体的组合物的组合物，所述组合物任选地与单层脂质体一起，所述脂质体含有至少一种显像剂并悬浮于含有所述显像剂的含水介质中，其中所述脂质体包含 中性磷脂和带电荷的磷脂，脂质体的平均粒径为50-3000nm，并且填充脂质体内部的任何水相中显像剂的浓度基本上与脂质体在其中的含水介质中的浓度相同 暂停。 有关的造影剂通常是X射线，MRI或超声造影剂。
-
公开(公告)号：EP0752889B1
公开(公告)日：2002-06-26
申请号：EP95913223.4
申请日：1995-03-27
发明人： KLAVENESS, Jo , BERG, Arne , JACOBSEN, Trond Vegard , RONGVED, Pal , EGE, Thorfinn , KIKUCHI, Hiroshi, Daiichi Pharmaceutical Co., Ltd. , YACHI, Kiyoto, Daiichi Pharmaceutical Co., Ltd.
CPC分类号： A61K49/227 , A61K49/0466 , A61K49/1812
摘要： The invention provides a diagnostic composition for administration to human or animal subjects the composition containing multilamellar liposomes, optionally together with unilamellar liposomes, the liposomes containing at least one imaging agent and being suspended in an aqueous medium containing said imaging agent, wherein the liposomes comprise a neutral phospholipid and a charged phospholipid, the average particle diameter of the liposomes is 50-3000 nm and the concentration of imaging agent in any aqueous phase filling the interior of the liposomes is substantially the same as that in the aqueous medium in which the liposomes are suspended. The contrast agents concerned are typically X-ray, MRI or ultrasound contrast agents.
-
3.发明授权
公开(公告)号：EP0523116B1
公开(公告)日：1996-06-19
申请号：EP91907007.8
申请日：1991-03-30
申请人： NYCOMED IMAGING AS
IPC分类号： A61K49/00
CPC分类号： A61K49/126 , A61K49/085 , A61K49/103 , A61K49/106 , A61K49/16 , A61K49/18 , A61K49/1812 , A61K49/1854 , A61K49/1863 , A61K49/1875 , A61K49/20 , Y10S436/806 , Y10S514/836 , Y10T436/24
摘要： The use of superparamagnetic particles and of paramagnetic materials (such as lanthanide chelates) as contrast agents in magnetometric analysis, especially imaging, and in particular structural and functional, diagnosis or imaging is described.
-
-
搜索结果
3 条记录 (耗时 0.009 秒)
