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公开(公告)号：EP1712562A1
公开(公告)日：2006-10-18
申请号：EP04808172.3
申请日：2004-12-27
发明人： TAKEOKA, Shinji , TSUCHIDA, Eishun , SOU, Keitaro
IPC分类号： C07K14/805
CPC分类号： C07K14/805
摘要： The present invention provides a method for purifying hemoglobin from red blood cells, wherein the red blood cells are deep-frozen and preserved, and then purified.
摘要翻译： 本发明提供了一种从红细胞中纯化血红蛋白的方法，其中将红细胞进行深冻和保存，然后进行纯化。
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公开(公告)号：EP1420010A1
公开(公告)日：2004-05-19
申请号：EP02796353.7
申请日：2002-08-21
申请人： Oxygenix Co., Ltd.
IPC分类号： C07C237/12 , C07K5/072 , A61K38/42 , A61K47/16 , A61P7/08
CPC分类号： C07K5/06113 , A61K9/1272 , A61K38/42 , A61K47/186 , C07C237/12
摘要： Provided is a zwitterionic lipid compound represented by formula (I) given below:
In formula (I), m and n are independently integers of 1 to 4, p is an integer of 7 to 21, one R is NH 3 + , and each other R is H.摘要翻译： 本发明提供由下式（I）表示的两性离子型脂质化合物：式（I）中，m和n分别为1〜4的整数，p为7〜21的整数，1个为NH 3 + >，并且彼此R是H.
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公开(公告)号：EP1219659B1
公开(公告)日：2010-07-28
申请号：EP00954985.8
申请日：2000-08-24
申请人： WASEDA UNIVERSITY
IPC分类号： C08G65/333 , C07C237/22 , C07K5/06 , C07K5/08 , C07K5/10 , C08B37/00 , C07C229/26 , C07K5/02 , C07K14/00 , C07C233/47 , C07K7/02
CPC分类号： C07C237/22 , C07C229/26 , C07C233/47 , C07C271/22 , C07K5/02 , C07K5/0215 , C07K7/02 , C07K14/001
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公开(公告)号：EP1906924B1
公开(公告)日：2018-05-02
申请号：EP06747265.4
申请日：2006-06-05
CPC分类号： A61K9/0019 , A61K9/1271 , A61K51/1227 , Y10S977/906
摘要： The present invention pertains to a bone marrow-directing drug delivery material that includes at least one fine particle, wherein the fine particle includes an anionic moiety on a surface of the particle. Also disclosed are uses of the material set forth herein for the prevention, treatment, or diagnosis of a disease of bone, cartilage, bone marrow, or a joint. Also disclosed are methods of preventing, treating, or diagnosing a disease of bone, cartilage, bone marrow, or a joint in a subject, involving administering to the subject a pharmaceutically effective amount of the material of the present invention.
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公开(公告)号：EP1340740B1
公开(公告)日：2010-09-08
申请号：EP01993596.4
申请日：2001-11-09
申请人： WASEDA UNIVERSITY
发明人： TSUCHIDA, Eishun , TAKEOKA, Shinji, Forest Tamagawa 404 , SOU, Keitaro , OHKAWA, Haruki , MORI, Katsura
IPC分类号： C07C233/47
CPC分类号： A61K9/1272 , C07C69/44 , C07C69/704 , C07C233/47 , C07C237/22 , C07C323/52 , C07C323/60 , C07H13/04 , C07H15/04
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公开(公告)号：EP1906924A1
公开(公告)日：2008-04-09
申请号：EP06747265.4
申请日：2006-06-05
CPC分类号： A61K9/0019 , A61K9/1271 , A61K51/1227 , Y10S977/906
摘要： The present invention pertains to a bone marrow-directing drug delivery material that includes at least one fine particle, wherein the fine particle includes an anionic moiety on a surface of the particle. Also disclosed are uses of the material set forth herein for the prevention, treatment, or diagnosis of a disease of bone, cartilage, bone marrow, or a joint. Also disclosed are methods of preventing, treating, or diagnosing a disease of bone, cartilage, bone marrow, or a joint in a subject, involving administering to the subject a pharmaceutically effective amount of the material of the present invention.
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公开(公告)号：EP1297843B1
公开(公告)日：2008-02-13
申请号：EP00985867.1
申请日：2000-12-25
申请人： WASEDA UNIVERSITY
CPC分类号： A61K31/525 , A61K31/045 , A61K31/198 , A61K31/7004 , A61K31/7016 , A61K38/42 , A61K47/6445
摘要： A method whereby hemoglobin vesicles containing oxidized methemoglobin are reduced by light irradiation to thereby recover the oxygen-coordination ability; and an apparatus therefore. An amino acid, sugars, alcohols and flavins, each in an appropriate amount, are added to the internal aqueous phase of hemoglobin vesicles. When the hemoglobin is oxidized and thus the content of methemoglobin is increased, the vesicles are reduced by irradiating with light so that the ability to coordinate oxygen is recovered and the function is sustained.
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