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1.发明授权
公开(公告)号：EP2157096B1
公开(公告)日：2013-02-20
申请号：EP08753107.5
申请日：2008-05-16
发明人： TAKEOKA, Shinji , OBATA, Yosuke , TAJIMA, Shoji , ITO, Manabu , MIZUNO, Atsushi , NISHIYAMA, Natsuko , TAKEUCHI, Yoshito
IPC分类号： A61K38/43 , A61K47/18 , A61K47/42 , C07C229/16 , C07C237/12
CPC分类号： A61K9/1272 , A61K9/1273 , C07C237/12 , C07C271/22
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公开(公告)号：EP1219659B1
公开(公告)日：2010-07-28
申请号：EP00954985.8
申请日：2000-08-24
申请人： WASEDA UNIVERSITY
IPC分类号： C08G65/333 , C07C237/22 , C07K5/06 , C07K5/08 , C07K5/10 , C08B37/00 , C07C229/26 , C07K5/02 , C07K14/00 , C07C233/47 , C07K7/02
CPC分类号： C07C237/22 , C07C229/26 , C07C233/47 , C07C271/22 , C07K5/02 , C07K5/0215 , C07K7/02 , C07K14/001
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公开(公告)号：EP1712562A1
公开(公告)日：2006-10-18
申请号：EP04808172.3
申请日：2004-12-27
发明人： TAKEOKA, Shinji , TSUCHIDA, Eishun , SOU, Keitaro
IPC分类号： C07K14/805
CPC分类号： C07K14/805
摘要： The present invention provides a method for purifying hemoglobin from red blood cells, wherein the red blood cells are deep-frozen and preserved, and then purified.
摘要翻译： 本发明提供了一种从红细胞中纯化血红蛋白的方法，其中将红细胞进行深冻和保存，然后进行纯化。
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公开(公告)号：EP1906924B1
公开(公告)日：2018-05-02
申请号：EP06747265.4
申请日：2006-06-05
CPC分类号： A61K9/0019 , A61K9/1271 , A61K51/1227 , Y10S977/906
摘要： The present invention pertains to a bone marrow-directing drug delivery material that includes at least one fine particle, wherein the fine particle includes an anionic moiety on a surface of the particle. Also disclosed are uses of the material set forth herein for the prevention, treatment, or diagnosis of a disease of bone, cartilage, bone marrow, or a joint. Also disclosed are methods of preventing, treating, or diagnosing a disease of bone, cartilage, bone marrow, or a joint in a subject, involving administering to the subject a pharmaceutically effective amount of the material of the present invention.
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公开(公告)号：EP2116599B1
公开(公告)日：2014-08-06
申请号：EP07849971.2
申请日：2007-11-26
申请人： Waseda University
发明人： TAKEOKA, Shinji , TAKEDA, Naoya , KURUMIZAKA, Hitoshi , SAKANE, Isao , IKEGAYA, Namiko , OBATA, Yosuke , SAITO, Syunsuke
IPC分类号： C12N15/09 , C07C237/12 , C07K5/02 , C07K5/033 , C07K5/06
CPC分类号： C07C237/22 , C07C237/08 , C07C237/12 , C07K5/021 , C07K5/06086 , C07K5/0815
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6.发明公开AMPHIPATHIC MOLECULE, MOLECULAR AGGREGATE COMPRISING THE AMPHIPATHIC MOLECULE, AND USE OF THE MOLECULAR AGGREGATE 有权AMPHIPATHISCHESMOLEKÜL，MOLEKULARES AGGREGAT MIT DEM AMPHIPATHISCHESMOLEKÜLUND VERWENDUNG DES MOLEKULAREN AGGREGATS
公开(公告)号：EP2157096A1
公开(公告)日：2010-02-24
申请号：EP08753107.5
申请日：2008-05-16
发明人： TAKEOKA, Shinji , OBATA, Yosuke , TAJIMA, Shoji , ITO, Manabu , MIZUNO, Atsushi , NISHIYAMA, Natsuko , TAKEUCHI, Yoshito
IPC分类号： C07K2/00 , A61K38/43 , A61K47/18 , A61K47/42 , C07C229/16 , C07C237/12 , C12N15/09
CPC分类号： A61K9/1272 , A61K9/1273 , C07C237/12 , C07C271/22
摘要： The present invention provides an amphiphilic molecule having a plurality of zwitterionic functional groups in its hydrophilic moiety and a molecular assembly comprising the amphiphilic molecule as a constituent lipid. According to a preferred embodiment of the present invention, the molecular assembly of the present invention forms a stable vesicular structure under a physiological pH environment to carry a substance of interest in the vesicular structure, and can release the substance of interest to the outside of the vesicular structure when it is deformed under an acidic pH environment. The molecular assembly of the present invention can be used as a carrier for a drug, a probe, a nucleic acid, a protein or the like.
摘要翻译： 本发明提供在其亲水部分具有多个两性离子官能团的两亲分子和包含两亲分子作为构成脂质的分子组合。 根据本发明的优选实施方案，本发明的分子组装体在生理pH环境下形成稳定的囊状结构，以便携带目的物质在囊状结构中，并且可将感兴趣的物质释放到 当它在酸性pH环境下变形时的囊泡结构。 本发明的分子组装体可以用作药物，探针，核酸，蛋白质等的载体。
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公开(公告)号：EP2116599A1
公开(公告)日：2009-11-11
申请号：EP07849971.2
申请日：2007-11-26
申请人： Waseda University
发明人： TAKEOKA, Shinji , TAKEDA, Naoya , KURUMIZAKA, Hitoshi , SAKANE, Isao , IKEGAYA, Namiko , OBATA, Yosuke , SAITO, Syunsuke
IPC分类号： C12N15/09 , C07C237/12 , C07K5/02 , C07K5/033 , C07K5/06
CPC分类号： C07C237/22 , C07C237/08 , C07C237/12 , C07K5/021 , C07K5/06086 , C07K5/0815
摘要： The present invention provides a reagent for introducing a protein or gene into a cell. The reagent of the present invention is, for example, a reagent for introducing a protein or gene into a cell, which comprises a composition comprising a cationic amino acid type lipid represented by the following formula (I)-1:
(wherein in formula (I)-1: L is a single bond, -CONH-, or -S-S-; M 1 is -(CH 2 ) k - or -(CH 2 CH 2 O) k - (wherein k is an integer between 0 and 14); and m1 and m2 are each independently an integer between 11 and 21 (in this regard, when providing a reagent for introducing a gene into a cell, the case where both m1 and m2 are 15 is excluded)).摘要翻译： 本发明提供了将蛋白质或基因导入细胞的试剂。 本发明的试剂是例如将蛋白质或基因导入细胞的试剂，其包含含有下式（I）-1表示的阳离子型氨基酸型脂质的组合物（式中，式 I）-1：L是单键，-CONH-或-SS-; M 1是 - （CH 2）k - 或 - （CH 2 CH 2 O）k - （其中k是0和 14）; m1和m2各自独立地为11〜21的整数（在这方面，当提供用于将基因导入细胞的试剂时，m1和m2均为15的情况除外））。
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公开(公告)号：EP1906924A1
公开(公告)日：2008-04-09
申请号：EP06747265.4
申请日：2006-06-05
CPC分类号： A61K9/0019 , A61K9/1271 , A61K51/1227 , Y10S977/906
摘要： The present invention pertains to a bone marrow-directing drug delivery material that includes at least one fine particle, wherein the fine particle includes an anionic moiety on a surface of the particle. Also disclosed are uses of the material set forth herein for the prevention, treatment, or diagnosis of a disease of bone, cartilage, bone marrow, or a joint. Also disclosed are methods of preventing, treating, or diagnosing a disease of bone, cartilage, bone marrow, or a joint in a subject, involving administering to the subject a pharmaceutically effective amount of the material of the present invention.
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公开(公告)号：EP1297843B1
公开(公告)日：2008-02-13
申请号：EP00985867.1
申请日：2000-12-25
申请人： WASEDA UNIVERSITY
CPC分类号： A61K31/525 , A61K31/045 , A61K31/198 , A61K31/7004 , A61K31/7016 , A61K38/42 , A61K47/6445
摘要： A method whereby hemoglobin vesicles containing oxidized methemoglobin are reduced by light irradiation to thereby recover the oxygen-coordination ability; and an apparatus therefore. An amino acid, sugars, alcohols and flavins, each in an appropriate amount, are added to the internal aqueous phase of hemoglobin vesicles. When the hemoglobin is oxidized and thus the content of methemoglobin is increased, the vesicles are reduced by irradiating with light so that the ability to coordinate oxygen is recovered and the function is sustained.
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10.发明公开THIN-FILMY POLYMERIC STRUCTURE AND METHOD OF PREPARING THE SAME 有权VERFAHREN ZU IHRER HERSTELLUNGDÜNNSCHICHTIGEPOLYMERSTRUKTUR
公开(公告)号：EP1785448A1
公开(公告)日：2007-05-16
申请号：EP05782124.1
申请日：2005-08-31
CPC分类号： C08J5/18 , B82Y30/00 , Y10T428/31504
摘要： A thin film polymer structure obtained by the steps of:
(a) causing polyfunctional molecules to adsorb to an area of an arbitrary shape in an interface between a substrate body and a liquid phase;
(b) polymerizing and/or crosslinking the adsorbing polyfunctional molecules to form a polymer thin film; and
(c) exfoliating the formed thin film from the substrate body.摘要翻译： 通过以下步骤获得的薄膜聚合物结构：（a）使多官能分子吸附在基体和液相之间的界面中的任意形状的区域; （b）使吸附的多官能分子聚合和/或交联以形成聚合物薄膜; 和（c）将所形成的薄膜从基底体剥离。
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