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公开(公告)号：EP1414522A2
公开(公告)日：2004-05-06
申请号：EP02768491.9
申请日：2002-08-09
IPC分类号： A61P3/12 , A61P7/10 , A61P21/00 , A61P25/08 , A61P27/02 , A61P27/06 , A61P35/00 , A61P35/02 , A61P43/00 , A61K31/635 , A61K45/06 , A61K31/18 , A61K31/415 , A61K31/42 , A61K31/4188
CPC分类号： A61K45/06 , A61K31/18 , A61K31/415 , A61K31/4188 , A61K31/42 , A61K31/4965 , A61K31/635 , A61K2300/00
摘要： Methods of treating or preventing carbonic anhydrase associated disorders or diseases in a subject in need of such treatment as prevention comprising the administration of cyclooxygenase -2 inhibitors, or structurally related compounds, having carbonic anhydrase inhibitory properties, as well as combinations of the cyclooxygenase -2 inhibitors, or structurally related compounds, with anti- inflammatory agents or drugs, antineoplastic agents or drugs or ophthalmic agents or drugs in methods of treatment and prevention of disorders or diseases.
摘要翻译： 在需要预防治疗的受试者中治疗或预防碳酸酐酶相关病症或疾病的方法，包括施用具有碳酸酐酶抑制性质的环氧合酶-2抑制剂或结构相关化合物，以及环氧合酶-2 抑制剂或结构上相关的化合物与抗炎剂或药物，抗肿瘤剂或药物或眼用药或治疗和预防疾病或疾病的方法中的药物。
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2.发明公开
公开(公告)号：EP1653940A1
公开(公告)日：2006-05-10
申请号：EP04760118.2
申请日：2004-04-22
发明人： MASFERRER, Jaime, L.
IPC分类号： A61K31/196 , A61K31/5685 , A61P35/00 , A61P19/10
CPC分类号： A61K45/06 , A61K31/00 , A61K31/135 , A61K31/196 , A61K31/415 , A61K31/42 , A61K31/445 , A61K31/454 , A61K31/505 , A61K31/506 , A61K31/5685 , A61K31/675 , A61K33/24 , A61K41/00 , A61K41/0038 , A61K2300/00
摘要： The present invention provides compositions and methods to treat, prevent or inhibit a neoplasia, a neoplasia-related disorder or osteoporosis in a mammal using a combination of a COX-2 inhibitor and an aromatase inhibitor.
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3.发明公开COMPOSITIONS OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND A CARBONIC ANHYDRASE INHIBITOR FOR THE TREATMENT OF NEOPLASIA 审中-公开组合物包含用于治疗肿瘤的选择性环氧合酶-2抑制剂和甲KARBONSÄUREANHYDRASEHEMMER
公开(公告)号：EP1526869A1
公开(公告)日：2005-05-04
申请号：EP03784730.8
申请日：2003-02-14
CPC分类号： A61K31/18 , A61K31/415 , A61K31/4188 , A61K31/42 , A61K31/4965 , A61K31/635 , A61K45/06 , A61K2300/00
摘要： The present invention provides compositions and methods for the treatment of neoplasia in a subject. More particularly, the invention provides a combination therapy for the treatment of neoplasia comprising the administration to a subject of a carbonic anhydrase inhibitor in combination with a cyclooxygenase-2 selective inhibitor.
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公开(公告)号：EP1414526A2
公开(公告)日：2004-05-06
申请号：EP02731524.1
申请日：2002-04-25
发明人： MCKEARN, John, P. , GORDON, Gary, B. , CUNNINGHAM, James, J. , GATELY, Stephen, T. , KOKI, Alane, T. , MASFERRER, Jaime, L.
CPC分类号： A61K31/00 , A61K31/135 , A61K31/415 , A61K31/42 , A61K31/445 , A61K31/454 , A61K31/505 , A61K31/506 , A61K31/5685 , A61K31/675 , A61K33/24 , A61K41/00 , A61K41/0038 , A61K45/06 , A61K2300/00
摘要： The present invention provides combinations of a DNA topoisomerase I inhibiting agent and a selective COX-2 inhibiting agent for preventing, treating, and/or reducing the risk of developing a neoplasia disorder in a mammal.
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5.发明公开METHOD OF USING A COX-2 INHIBITOR AND A TOPOISOMERASE II INHIBITOR AS A COMBINATION THERAPY IN THE TREATMENT OF NEOPLASIA 审中-公开USE COX-2抑制剂的方法技术和拓扑异构酶II抑制剂THAN THERAPY组合治疗肿瘤的
公开(公告)号：EP1572239A1
公开(公告)日：2005-09-14
申请号：EP03814090.1
申请日：2003-12-17
发明人： MASFERRER, Jaime, L.
CPC分类号： A61K31/135 , A61K31/18 , A61K31/415 , A61K31/42 , A61K31/445 , A61K31/473 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/675 , A61K31/7052 , A61K33/24 , A61K41/00 , A61K41/0038 , A61K45/06 , C07D215/54 , C07D311/22 , C07D311/58 , C07D311/92 , C07D335/06 , C07D401/12 , C07D405/04 , C07D407/04 , C07D407/12 , C07D409/04 , C07D471/04 , C07D491/04 , C07D493/04 , A61K2300/00
摘要： The present invention provides compositions and methods to treat, prevent or inhibit a neoplasia or a neoplasia-related disorder in a mammal using a combination of a COX-2 inhibitor and a topoisomerase II inhibitor.
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6.发明公开METHODS USING A COMBINATION OF A 3-HETEROARYL-2-INDOLINONE AND A CYCLOOXYGENASE-2 INHIBITOR FOR THE TREATMENT OF NEOPLASIA 审中-公开USE WITH A 3 - 杂芳基-2-吲哚满酮的组合以及环氧合酶-2抑制剂用于治疗肿瘤的，过程
公开(公告)号：EP1509224A1
公开(公告)日：2005-03-02
申请号：EP03734058.5
申请日：2003-05-15
IPC分类号： A61K31/4045 , A61K31/5375
CPC分类号： A61K45/06 , A61K31/135 , A61K31/382 , A61K31/405 , A61K31/41 , A61K31/415 , A61K31/416 , A61K31/4178 , A61K31/4196 , A61K31/42 , A61K31/445 , A61K31/4709 , A61K31/505 , A61K31/506 , A61K31/675 , A61K33/24 , A61K41/00 , A61K41/0038 , A61K2300/00
摘要： The present invention provides methods and compositions useful for treatment or prevention of neoplasia by administering a combination comprising a 3-heteroaryl-2-indolinone compound and a COX-2 selective inhibitor. Further provided are compositions, pharmaceutical compositions, and kits for treatment and prevention of neoplasia.
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7.发明公开COMBINATIONS COMPRISING AN HSP90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA 审中-公开组合的HSP90抑制剂和磷酸二酯酶抑制剂用于治疗肿瘤或预防
公开(公告)号：EP1682143A2
公开(公告)日：2006-07-26
申请号：EP04817484.1
申请日：2004-10-28
CPC分类号： A61K45/06
摘要： A method for treating or preventing neoplasia or a neoplasia-related disorder in a subject is provided, the method comprising administering to the subject an effective amount of a combination comprising an Hsp90 inhibitor and a phosphodiesterase inhibitor, and optionally a Cox-2 inhibitor.
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8.发明公开
公开(公告)号：EP1526895A2
公开(公告)日：2005-05-04
申请号：EP03709105.5
申请日：2003-02-14
CPC分类号： A61K31/18 , A61K31/415 , A61K31/4188 , A61K31/42 , A61K31/4965 , A61K31/635 , A61K45/06 , A61K2300/00
摘要： The current invention provides methods to treat or prevent carbonic anhydrase mediated diseases or disorders. The method generally comprises administering a tricyclic compound having a sulfonamide group to a subject wherein the compound inhibits carbonic anhydrase.
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9.发明公开COMBINATION OF CYCLOOXYGENASE-2 INHIBITORS AND THALIDOMIDE FOR THE TREATMENT OF NEOPLASIA 审中-公开组合环氧化酶-2抑制剂和沙利度胺治疗肿瘤的
公开(公告)号：EP1499315A1
公开(公告)日：2005-01-26
申请号：EP03728569.9
申请日：2003-04-25
发明人： MASFERRER, Jaime, L.
IPC分类号： A61K31/454 , A61P35/00
CPC分类号： A61K45/06 , A61K31/00 , A61K31/135 , A61K31/415 , A61K31/42 , A61K31/445 , A61K31/454 , A61K31/505 , A61K31/506 , A61K31/5685 , A61K31/675 , A61K33/24 , A61K41/00 , A61K41/0038 , A61K2300/00
摘要： The present invention provides compositions and methods for the treatment, prevention or inhibition of neoplasia by administering an effective amount of a cyclooxygenase-2 selective inhibitor in combination with an effective amount of thalidomide.
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10.发明公开UROGUANYLIN AND CYCLOOXYGENASE-2 INHIBITOR COMBINATIONS FOR INHIBITION OF INTESTINAL CANCER 审中-公开尿鸟苷素，和环氧合酶-2抑制剂组合用于结肠癌的抑制
公开(公告)号：EP1365753A2
公开(公告)日：2003-12-03
申请号：EP02702137.7
申请日：2002-02-04
发明人： MASFERRER, Jaime, L.
IPC分类号： A61K31/00
CPC分类号： A61K38/1709 , A61K2300/00
摘要： Disclosed is a method of retarding the development of polyps and prevention, inhibition and treatment of cancer in the intestine of a subject by administration of a composition comprising a peptide with the active domain of uroguanylin or any agonist peptide or compound binding to the guanylate cyclase receptor GC-C in the intestine in combination with a naturally occurring, derived from a naturally occurring, or a chemically synthesized cycloogenase-2 inhibitor, preferably a selective cyclooxygenase-2 inhibitor.
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