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1.发明公开THIAZOLE COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES 审中-公开THIAZOLVERBINDUNGEN ALS INTEGRINREZEPTORANTAGONISTEN
公开(公告)号：EP1572690A1
公开(公告)日：2005-09-14
申请号：EP03814226.1
申请日：2003-12-19
发明人： WENDT, John, A. , STENMARK, Heather , WU, Lisa , WANG, Yaping , CHEN, Barbara, B. , PENNING, Thomas, D. , DOWNS, Victoria , BOYS, Mark, L. , RUSSELL, Mark , SPANGLER, Dale, P.
IPC分类号： C07D471/04 , C07D417/14 , A61K31/427
CPC分类号： C07D417/14 , C07D471/04
摘要： The present invention relates to pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibiting or antagonizing the ανβ3 and/or the ανβ5 integrin without significantly inhibiting the ανβ6 integrin.
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2.发明公开COMBINATIONS COMPRISING AN HSP90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA 审中-公开组合的HSP90抑制剂和磷酸二酯酶抑制剂用于治疗肿瘤或预防
公开(公告)号：EP1682143A2
公开(公告)日：2006-07-26
申请号：EP04817484.1
申请日：2004-10-28
CPC分类号： A61K45/06
摘要： A method for treating or preventing neoplasia or a neoplasia-related disorder in a subject is provided, the method comprising administering to the subject an effective amount of a combination comprising an Hsp90 inhibitor and a phosphodiesterase inhibitor, and optionally a Cox-2 inhibitor.
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公开(公告)号：EP1572691A1
公开(公告)日：2005-09-14
申请号：EP03814227.9
申请日：2003-12-19
发明人： PENNING, Thomas, D. , KHILEVICH, Albert , CHEN, Barbara, B. , GANDHI, Preete , WANG, Yaping , DOWNS, Victoria , BOYS, Mark, L. , RUSSELL, Mark , SPANGLER, Dale, P. , HUFF, Renee, M.
IPC分类号： C07D471/04 , C07D401/14 , C07D405/14
CPC分类号： C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要： The present invention relates to pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibiting or antagonizing the αVβ3 and/or the α Vβ5 integrin without significantly inhibiting the α Vβ6 integrin.
摘要翻译： 本发明涉及包含式（I）化合物的药物组合物，以及选择性抑制或拮抗αVβ3和/或αVβ5整联蛋白而不显着抑制αVβ6整联蛋白的方法。
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公开(公告)号：EP1322623A2
公开(公告)日：2003-07-02
申请号：EP01973568.7
申请日：2001-09-27
发明人： ROGERS, Thomas , PENNING, Thomas, D. , LAN, Jiang , DEVADAS, Balekudru , RUMINISKI, Peter , YUAN, Chester , VANCAMP, Jennifer
IPC分类号： C07D239/14 , A61K31/505 , A61P35/00 , C07C279/14 , C07D405/12
CPC分类号： C07D239/14
摘要： The present invention relates to compounds, pharmaceutical compositions and method of using αvβ3 and/or αvβ5 selective integrin antagonists.
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公开(公告)号：EP1320363A1
公开(公告)日：2003-06-25
申请号：EP01975450.6
申请日：2001-09-27
发明人： RUMINISKI, Peter , PENNING, Thomas, D. , LAN, Jiang , DEVADAS, Balekudru , ROGERS, Thomas , YUAN, Chester , VANCAMP, Jennifer
IPC分类号： A61K31/365 , A61K31/366 , A61K31/37 , C07D233/50 , C07D239/14 , C07D307/33
CPC分类号： C07D405/12 , C07D309/30 , C07D405/14
摘要： The present invention relates to compounds, pharmaceutical compositions and method of using αvβ3 and/or αvβ5 selective integrin antagonists.
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公开(公告)号：EP1592421A1
公开(公告)日：2005-11-09
申请号：EP03800081.6
申请日：2003-12-22
发明人： BOYS, Mark, L. , SCHRETZMAN, Lori, A. , TOLLEFSON, Michael, B. , CHANDRAKUMAR, Nizal, S. , KHANNA, Ish, K. , NGUYEN, Maria , DOWNS, Victoria , MOHLER, Scott B. , GESICKI, Glen, J. , PENNING, Thomas, D. , CHEN, Barbara, B. , WANG, Yaping , KHILEVICH, Albert , DESAI, Bipinchandra, N. , YU, Yi , WENDT, John, A. , STENMARK, Heather , WU, Lisa , HUFF, Renee, M. , NAGARAJAN, Srinivasan R. , DEVADAS, Balekudru , LU, Hwang-Fun , RUSSELL, Mark , SPANGLER, Dale P. , PARIKH, Mihir D.
CPC分类号： A61K31/4245 , A61K31/4745
摘要： The present invention relates to pharmaceutical compositions comprising compounds of the Formula I, or a pharmaceutically acceptable salt thereof, and methods of selectively inhibiting or antagonizing the ανβ3 and/or the ανβ5 integrin without significantly inhibiting the ανβ6 integrin.
摘要翻译： 本发明涉及包含式I化合物或其药学上可接受的盐的药物组合物，以及选择性抑制或拮抗αvβ3和/或αvβ5整联蛋白而不显着抑制αvβ6整联蛋白的方法。
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公开(公告)号：EP1313705A1
公开(公告)日：2003-05-28
申请号：EP01968257.4
申请日：2001-08-29
申请人： Pharmacia Corporation , Khanna, Ish Kumar , Yu, Yi , Fun-Lu, Hwang , Chandrakumar, Nizal S. , Huff, Renee M. , Russell, Mark A. , Boys, Mark L. , Schretzman, Lori A. , Chen, Barbara B. , Desai, Bipinchandra N. , Nagarajan, Srinivasan Raj , Gasiecki, Alan F. , Penning, Thomas D. , Rogers, Thomas , Wendt, John Adam , Khilevich, Albert , Wang, Yaping
发明人： KHANNA, Ish, Kumar , YU, Yi , FUN-LU, Hwang , CHANDRAKUMAR, Nizal, S. , HUFF, Renee, M. , RUSSELL, Mark, A. , BOYS, Mark, L. , SCHRETZMAN, Lori, A. , CHEN, Barbara, B. , DESAI, Bipinchandra, N. , NAGARAJAN, Srinivasan, Raj , GASIECKI, Alan, F. , PENNING, Thomas, D. , ROGERS, Thomas , WENDT, John, Adam , KHILEVICH, Albert , WANG, Yaping , DEVADAS, Balekudra
IPC分类号： C07D213/74 , C07D401/12 , C07D213/73 , C07D471/04 , A61K31/4427 , A61K31/553 , A61P35/00 , A61P31/00
CPC分类号： C07D213/73 , C07D213/74 , C07D401/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively inhibiting or antagonizing the αvβ3 and/or the αvβ5 integrin.
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8.发明公开
公开(公告)号：EP1289983A2
公开(公告)日：2003-03-12
申请号：EP01948424.5
申请日：2001-06-15
发明人： NAGARAJAN, Scrinivasan, Raj , KHANNA, Ish, Kumar , TOLLEFSON, Michael, B. , MOHLER, Scott, B. , CHEN, Barbara , RUSSELL, Mark , DEVADAS, Balekudru , PENNING, Thomas, D. , SCHRETZMAN, Lori, A. , SPANGLER, Dale, P. , BOYS, Mark, Laurence , CHANDRAKUMAR, Nizal, Samuel , LU, Hwang-Fun
IPC分类号： C07D413/12
CPC分类号： C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively antagonizing the αξβ3 and/or the αξβ5 integrin without significantly antagonizing the IIb/IIIa integrin.
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