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公开(公告)号：EP2326641B1
公开(公告)日：2014-09-03
申请号：EP09790061.7
申请日：2009-07-02
IPC分类号： C07D403/04 , C07D471/14 , A61K31/502 , A61K31/5025 , A61P35/00
CPC分类号： A61K31/502 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D471/04 , C07D471/14
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公开(公告)号：EP2326641A2
公开(公告)日：2011-06-01
申请号：EP09790061.7
申请日：2009-07-02
IPC分类号： C07D403/04 , C07D471/14 , A61K31/502 , A61K31/5025 , A61P35/00
CPC分类号： A61K31/502 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D471/04 , C07D471/14
摘要： Polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
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3.发明授权BRIDGED BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS 有权AS AXL抑制剂SUITABLE桥接双环杂芳基取代的三唑
公开(公告)号：EP2328888B1
公开(公告)日：2012-11-07
申请号：EP09790063.3
申请日：2009-07-02
发明人： SINGH, Rajinder , HOLLAND, Sacha , LITVAK, Joane , GOFF, Dane , ZHANG, Jing , HECKRODT, Thilo, J.
IPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D471/18 , A61K31/4196 , A61P35/00
CPC分类号： C07D403/04 , A61K31/502 , C07D221/22 , C07D237/26 , C07D237/34 , C07D401/14 , C07D403/14 , C07D471/18
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4.发明授权COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY 有权ZUSAMMENSETZUNGEN UND VERFAHREN ZUR INHIBIERUNG DES JAK-PFADES
公开(公告)号：EP2389372B1
公开(公告)日：2015-09-09
申请号：EP10701189.2
申请日：2010-01-22
发明人： LI, Hui , HECKRODT, Thilo, J. , CHEN, Yan , MCMURTRIE, Darren, John , TAYLOR, Vanessa , SINGH, Rajinder , DING, Pingyu , THOTA, Sambaiah , YEN, Rose
IPC分类号： C07D401/12 , C07D403/14 , C07D413/12 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D491/08 , C07D498/04 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/54 , A61P27/02 , A61P35/00 , A61P37/00
CPC分类号： C07D413/12 , A61K31/155 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/635 , A61K31/675 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/04 , C07D413/14 , C07D419/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/08 , C07D498/04 , C07F9/65583
摘要： Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.
摘要翻译： 公开了式I化合物，含有它们的组合物，以及用于化合物和组合物用于治疗JAK途径的调节或JAK激酶，特别是JAK 2和JAK 3的抑制在治疗上有用的条件的方法。
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5.发明公开BRIDGED BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS 有权AS AXL抑制剂SUITABLE桥接双环杂芳基取代的三唑
公开(公告)号：EP2328888A1
公开(公告)日：2011-06-08
申请号：EP09790063.3
申请日：2009-07-02
发明人： SINGH, Rajinder , HOLLAND, Sacha , LITVAK, Joane , GOFF, Dane , ZHANG, Jing , HECKRODT, Thilo, J.
IPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D471/18 , A61K31/4196 , A61P35/00
CPC分类号： C07D403/04 , A61K31/502 , C07D221/22 , C07D237/26 , C07D237/34 , C07D401/14 , C07D403/14 , C07D471/18
摘要： Bridged bicyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase AxI. Methods of using the compounds in treating diseases or conditions associated with AxI activity are also disclosed.
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6.发明公开COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY 审中-公开ZUSAMMENSETZUNGEN UND VERFAHREN ZUR HEMMUNG DES JAK-SIGNALWEGES
公开(公告)号：EP2598500A1
公开(公告)日：2013-06-05
申请号：EP11745858.8
申请日：2011-07-27
发明人： LI, Hui , HECKRODT, Thilo, J. , CHEN, Yan , MCMURTRIE, Darren, John , TAYLOR, Vanessa , SINGH, Rajinder , DING, Pingyu , YEN, Rose
IPC分类号： C07D413/12 , C07D413/14 , A61K31/506 , A61P27/00 , A61P37/06
CPC分类号： C07D413/12 , C07B59/002 , C07B2200/05 , C07F9/65583
摘要： Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful. Also disclosed are methods of making the compounds.
摘要翻译： 公开了式I化合物，含有它们的组合物，以及用于化合物和组合物用于治疗JAK途径的调节或JAK激酶，特别是JAK 2和JAK 3的抑制在治疗上有用的条件的方法。 还公开了制备该化合物的方法。
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公开(公告)号：EP2389372A1
公开(公告)日：2011-11-30
申请号：EP10701189.2
申请日：2010-01-22
发明人： LI, Hui , HECKRODT, Thilo, J. , CHEN, Yan , MCMURTRIE, Darren, John , TAYLOR, Vanessa , SINGH, Rajinder , DING, Pingyu , THOTA, Sambaiah , YEN, Rose
IPC分类号： C07D401/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D491/08 , C07D498/04 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/54
CPC分类号： C07D413/12 , A61K31/155 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/635 , A61K31/675 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/04 , C07D413/14 , C07D419/14 , C07D451/02 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/08 , C07D498/04 , C07F9/65583
摘要： Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful.
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