公开(公告)号：EP1937650A1

公开(公告)日：2008-07-02

申请号：EP06769700.3

申请日：2006-08-01

申请人： S*BIO Pte Ltd

发明人： CHEN, Dizhong ,  DENG, Weiping ,  LEE, Ken, Chi, Lik ,  LYE, Pek Ling ,  SUN, Eric, T. ,  WANG, Haishan ,  YU, Niefang

IPC分类号： C07D235/04 ,  A61K31/4184 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  C07D235/06 ,  C07D235/08 ,  C07D235/10 ,  C07D235/12 ,  C07D235/16 ,  C07D235/22 ,  C07D401/04 ,  C07D403/04

CPC分类号： C07D235/08 ,  C07D235/06 ,  C07D235/10 ,  C07D235/12 ,  C07D235/14 ,  C07D235/16 ,  C07D235/24 ,  C07D401/04 ,  C07D403/04

摘要： The present invention relates to compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to heterocyclic compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.

摘要翻译： 本发明涉及作为组蛋白脱乙酰酶抑制剂的化合物。 更具体地说，本发明涉及杂环化合物及其制备方法。 这些化合物可用作治疗增殖性疾病以及与具有组蛋白脱乙酰酶（HDAC）活性的酶有关或与其相关的其他疾病的药物。

公开(公告)号：EP1937650B1

公开(公告)日：2011-06-15

申请号：EP06769700.3

申请日：2006-08-01

申请人： S*BIO Pte Ltd

发明人： CHEN, Dizhong ,  DENG, Weiping ,  LEE, Ken, Chi, Lik ,  LYE, Pek Ling ,  SUN, Eric, T. ,  WANG, Haishan ,  YU, Niefang

IPC分类号： C07D235/04 ,  A61K31/4184 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  C07D235/06 ,  C07D235/08 ,  C07D235/10 ,  C07D235/12 ,  C07D235/16 ,  C07D235/22 ,  C07D401/04 ,  C07D403/04

CPC分类号： C07D235/08 ,  C07D235/06 ,  C07D235/10 ,  C07D235/12 ,  C07D235/14 ,  C07D235/16 ,  C07D235/24 ,  C07D401/04 ,  C07D403/04

摘要： The present invention relates to compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to heterocyclic compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.

公开(公告)号：EP2064211A1

公开(公告)日：2009-06-03

申请号：EP06784289.8

申请日：2006-09-20

申请人： S*BIO Pte Ltd

发明人： LEE, Ken Chi Lik ,  SUN, Eric, T. ,  WANG, Haishan

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04

摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).

公开(公告)号：EP1685094A1

公开(公告)日：2006-08-02

申请号：EP04775672.1

申请日：2004-10-26

申请人： S*Bio Pte Ltd

发明人： LIM, Ze-Yi ,  WANG, Haishan ,  ZHOU, Yan

IPC分类号： C07C275/50 ,  C07C275/54 ,  C07C311/58

CPC分类号： C07D207/27 ,  C07C275/50 ,  C07C275/54 ,  C07C311/58 ,  C07C311/60 ,  C07C335/26 ,  C07D209/16 ,  C07D213/40 ,  C07D233/64 ,  C07D235/14 ,  C07D285/06 ,  C07D295/13 ,  C07D295/215 ,  C07D307/14 ,  C07D307/85 ,  C07D333/20 ,  C07D333/38

摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to acylurea/sulfonylurea containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities.

公开(公告)号：EP1682538A1

公开(公告)日：2006-07-26

申请号：EP04775673.9

申请日：2004-10-26

申请人： S*Bio Pte Ltd

发明人： STUNKEL, Walter, Monterey Park Condominium, ,  WANG, Haishan ,  YIN, Zheng

IPC分类号： C07D417/04 ,  C07D407/14 ,  C07D231/44 ,  C07D307/52 ,  C07D333/38 ,  C07D409/12 ,  C07D307/68 ,  A61K31/34 ,  A61K31/381 ,  A61K31/415 ,  A61K31/426 ,  A61K31/427 ,  A61K31/421 ,  A61P35/00

CPC分类号： C07D263/34 ,  A61K31/34 ,  A61K31/381 ,  A61K31/415 ,  A61K31/421 ,  A61K31/426 ,  A61K31/427 ,  C07D231/14 ,  C07D261/18 ,  C07D263/32 ,  C07D277/28 ,  C07D277/40 ,  C07D277/42 ,  C07D277/46 ,  C07D307/54 ,  C07D307/68 ,  C07D333/38 ,  C07D333/70 ,  C07D405/10 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  Y02A50/409 ,  Y02A50/411

摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to biaryl containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities. Formula (I), where Z is a single bond or C 1 -C 4 hydrocarbon, A is an aromatic ring, B is an aromatic ring.