公开(公告)号：EP1690538A4

公开(公告)日：2009-02-25

申请号：EP04819801

申请日：2004-11-29

申请人： SHIONOGI & CO

发明人： FUKUI YOSHIKAZU ,  SASATANI TAKASHI ,  MATSUMURA KEN-ICHI ,  ISHIZUKA NATSUKI ,  YANO TOSHISADA ,  KANDA YASUHIKO ,  CHOMEI NOBUO

IPC分类号： C07D261/08 ,  A61K31/42 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/428 ,  A61K31/435 ,  A61K31/4427 ,  A61K31/501 ,  A61K31/502 ,  A61K31/506 ,  A61K31/536 ,  A61K31/5377 ,  A61K31/5395 ,  A61P1/04 ,  A61P1/18 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P9/12 ,  A61P15/00 ,  A61P17/04 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P37/08 ,  A61P43/00 ,  C07D261/18 ,  C07D261/20 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12

CPC分类号： C07D417/12 ,  C07D261/08 ,  C07D261/18 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12

摘要： Compounds represented by the formula (I):[wherein R1 to R10 each independently is hydrogen, halogeno, optionally substituted lower alkyl, etc.; X1 is -O-, -S-, -NR11- (wherein R11 is hydrogen, lower alkyl, etc.), -CR12R13CO-, -(CR12R13)mO-, or -O(CR12R13)m- (wherein R12 and R13 each independently is hydrogen or lower alkyl and m is an integer of 1 to 3), etc.; X2 is a single bond, -O-, -S-, -NR14- (wherein R14 is hydrogen, lower alkyl, etc., provided that R14 may be bonded to R6 to form a ring in cooperation with the adjacent atoms), or -CR15R16- (wherein R15 and R16 each independently is hydrogen or lower alkyl, provided that R15 may be bonded to R6 or R10 to form a ring in cooperation with the adjacent carbon atoms and R16 and R9 in combination may form a bond); and X3 is COOR17, C(=NR17)NR18OR19, etc.], pharmaceutically acceptable salts of the compounds, or solvates of any of these.

公开(公告)号：EP0924207A4

公开(公告)日：2001-06-13

申请号：EP97935855

申请日：1997-08-22

申请人： SHIONOGI & CO

发明人： ISHIZUKA NATSUKI ,  MATSUMURA KEN-ICHI ,  SAKAI KATSUNORI ,  KONOIKE TOSHIRO ,  YORIFUJI TADAHIKO ,  HARA SEIJIRO ,  MATSUO YOSHIYUKI

IPC分类号： C07D311/22 ,  C07D311/60 ,  C07D407/04 ,  C07D407/14 ,  C07D409/04 ,  C07D409/14 ,  C07D311/58 ,  C07D311/64 ,  C07D311/68 ,  C07D335/06 ,  C07D407/12 ,  A61K31/352

CPC分类号： C07D407/04 ,  C07D311/60 ,  C07D407/14 ,  C07D409/04 ,  C07D409/14

摘要： Compounds represented by general formula (I), pharmaceutically acceptable salts thereof, and hydrates of the same; and medicinal compositions such as endothelin receptor antagonists, remedies for peripheral circulatory insufficiency or macrophage foaming inhibitors containing these compounds. In said formula (I), R?1, R2, R3 and R4¿ independently represent each hydrogen, optionally substituted alkyl, hydroxy, optionally substituted alkoxy, etc.; R5 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted heterocycle, etc.; R6 represents hydrogen, optionally substituted alkyl, etc.; R7 represents hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, optionally substituted heterocycle, etc.; A represents S or O; and the broken line means the presence or absence of a bond.

公开(公告)号：EP1057824A4

公开(公告)日：2002-01-09

申请号：EP99902911

申请日：1999-02-16

申请人： SHIONOGI & CO

发明人： KONOIKE TOSHIRO ,  YORIFUJI TADAHIKO ,  SHINOMOTO SHOJI ,  IDE YUTAKA ,  OHYA TAKASHI ,  MATSUMURA KEN-ICHI

IPC分类号： C07D311/30 ,  C07D407/04 ,  A61K31/35 ,  A61K31/36 ,  A61K31/38 ,  C07B57/00 ,  C07D335/06 ,  C07D409/04

CPC分类号： C07D407/04 ,  C07D311/30 ,  Y02P20/582

摘要： A process for producing a compound represented by formula (II) (wherein R?1, R2, R3, and R4¿ each independently represents hydrogen, alkyl, alkoxy, etc.; R5 represents alkyl or alkoxyalkyl; A represents O or S; Ar represents aryl, etc.; * indicates the position of an asymmetric carbon atom and that the compound is the (R) or (S) isomer; and Q represents an optically active reagent), characterized by isolating the target compound as crystals from a solution or suspension containing a compound represented by formula (II) (wherein * indicates the position of an asymmetric carbon atom and that the compound is the (R) or (S) isomer or is a mixture of both, and the other symbols have the same meanings as the above).