公开(公告)号：EP1690538A4

公开(公告)日：2009-02-25

申请号：EP04819801

申请日：2004-11-29

申请人： SHIONOGI & CO

发明人： FUKUI YOSHIKAZU ,  SASATANI TAKASHI ,  MATSUMURA KEN-ICHI ,  ISHIZUKA NATSUKI ,  YANO TOSHISADA ,  KANDA YASUHIKO ,  CHOMEI NOBUO

IPC分类号： C07D261/08 ,  A61K31/42 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/428 ,  A61K31/435 ,  A61K31/4427 ,  A61K31/501 ,  A61K31/502 ,  A61K31/506 ,  A61K31/536 ,  A61K31/5377 ,  A61K31/5395 ,  A61P1/04 ,  A61P1/18 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P9/12 ,  A61P15/00 ,  A61P17/04 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P37/08 ,  A61P43/00 ,  C07D261/18 ,  C07D261/20 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12

CPC分类号： C07D417/12 ,  C07D261/08 ,  C07D261/18 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12

摘要： Compounds represented by the formula (I):[wherein R1 to R10 each independently is hydrogen, halogeno, optionally substituted lower alkyl, etc.; X1 is -O-, -S-, -NR11- (wherein R11 is hydrogen, lower alkyl, etc.), -CR12R13CO-, -(CR12R13)mO-, or -O(CR12R13)m- (wherein R12 and R13 each independently is hydrogen or lower alkyl and m is an integer of 1 to 3), etc.; X2 is a single bond, -O-, -S-, -NR14- (wherein R14 is hydrogen, lower alkyl, etc., provided that R14 may be bonded to R6 to form a ring in cooperation with the adjacent atoms), or -CR15R16- (wherein R15 and R16 each independently is hydrogen or lower alkyl, provided that R15 may be bonded to R6 or R10 to form a ring in cooperation with the adjacent carbon atoms and R16 and R9 in combination may form a bond); and X3 is COOR17, C(=NR17)NR18OR19, etc.], pharmaceutically acceptable salts of the compounds, or solvates of any of these.

公开(公告)号：EP1325909A4

公开(公告)日：2004-12-08

申请号：EP01965673

申请日：2001-09-17

申请人： SHIONOGI & CO

发明人： FUKUI YOSHIKAZU ,  ADACHI MAKOTO ,  SASATANI TAKASHI

IPC分类号： A61P5/28 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D491/06 ,  C07D207/09 ,  A61K31/55

CPC分类号： C07D491/06

摘要： Compounds of the general formula (|) have affinity for serotonin receptor and are useful as remedies for various central nervous system diseases: (|) wherein R1 is hydrogen; R2 is hydrogen or lower alkyl; R3 is hydrogen, -COOR12, or the like, and R4 is hydrogen, lower alkyl, or the like, or alternatively R?3 and R4¿ may be united to form =O or =S; R5 is hydrogen, or alternatively R?3 and R5¿ may be united to form a single bond; R6 is hydrogen, -COOR24, or the like; R7 is hydrogen, halogeno, lower alkyl, or the like; R8 is hydrogen, lower alkyl, cycloalkyl, or the like; and R?9, R10 and R11¿ are each independently hydrogen, halogeno, lower alkyl, or the like.

公开(公告)号：EP1806342A4

公开(公告)日：2010-02-17

申请号：EP05800158

申请日：2005-10-28

申请人： SHIONOGI & CO

发明人： ISHIZUKA NATSUKI ,  SASATANI TAKASHI ,  HIRAMATSU YOSHIHARU ,  INAGAKI MASANAO ,  ODAN MASAHIDE ,  HASHIZUME HIROSHI ,  MITSUMORI SUSUMU ,  FUJII YASUHIKO ,  FUKUI YOSHIKAZU ,  WATANABE HIDEAKI ,  SATO JUN

IPC分类号： C07D213/82

CPC分类号： C07D213/82