公开(公告)号：EP1124977A1

公开(公告)日：2001-08-22

申请号：EP00958742.9

申请日：2000-08-25

申请人： TRANSGENE S.A. ,  EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL)

发明人： VAN RAAIJ, Mark, Johan ,  CUSACK, Stephen ,  LEGRAND, Valérie ,  LEISSNER, Philippe ,  MEHTALI, Majid

IPC分类号： C12N15/861 ,  C12N5/10 ,  C12N15/34 ,  C07K14/075 ,  A61K48/00

CPC分类号： C07K14/005 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2810/10 ,  C12N2810/40 ,  C12N2810/851 ,  C12N2810/854 ,  C12N2810/859

摘要： The invention concerns a modified adenoviral fibre comprising at least one mutation at the level of one or several residues included in the region of said fibre extending from layer A to layer B and including the loop AB.

公开(公告)号：EP0682708B9

公开(公告)日：2005-03-02

申请号：EP95903829.0

申请日：1994-12-13

申请人： TRANSGENE S.A.

发明人： MEHTALI, Majid ,  GUSS, Tania

IPC分类号： C12N15/49 ,  C07K14/16 ,  A61K48/00 ,  A61K39/21 ,  C12N15/86 ,  C12N5/10

CPC分类号： C12N15/86 ,  A61K38/00 ,  A61K48/00 ,  C07K14/005 ,  C12N2740/13043 ,  C12N2740/16322 ,  C12N2830/002 ,  C12N2830/60 ,  C12N2840/203

摘要： A composition resulting from a combination of trans-dominant variants of two viral proteins from a single virus, and the use thereof as a combination product are disclosed. A vector for expressing the two variants, a eukaryotic cell containing same, and a pharmaceutical composition for treating viral infections, are also disclosed.

公开(公告)号：EP0842279B1

公开(公告)日：2001-10-31

申请号：EP96927107.1

申请日：1996-07-30

申请人： TRANSGENE S.A.

发明人： LUSKY, Monika ,  MEHTALI, Majid

IPC分类号： C12N15/56 ,  C12N7/01 ,  C12N5/10 ,  A61K48/00

CPC分类号： C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/10352 ,  C12N2800/30

摘要： Novel helper vectors are provided for complementing defective recombinant viral vectors, characterised in that they are provided with recombination sequences recognised by a recombinase. A complementation cell expressing the recombinase, and a method for preparing recombinant viral vectors as infectious viral particles for transferring and expressing genes of interest in a host organism or cell, are also provided. The invention is particularly suitable for use in gene therapy, especially in humans.

公开(公告)号：EP0988391A2

公开(公告)日：2000-03-29

申请号：EP98928412.0

申请日：1998-06-02

申请人： TRANSGENE S.A.

发明人： MEHTALI, Majid ,  LEROY, Pierre ,  MICHOU, Anne-Isabelle

IPC分类号： C12N15/86 ,  C12N5/10 ,  A61K48/00 ,  C12N15/26 ,  C07K14/55 ,  C12N15/12 ,  C07K14/745

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2830/42 ,  C12N2840/44

摘要： The invention concerns a recombinant adenoviral vector driving from an adenovirus genome at least by deleting all or part of the E1 region, said adenoviral vector comprising an expression cassette of a gene of interest placed under the control of elements necessary for its expression in a host cell or a host organism, said elements required for its expression including at least a splicing sequence. The invention is characterised in that said splicing sequence is derived from a eukaryotic nuclear gene selected among the ovalbumen genes, α or β-globine, collagen and factor VIII of mammals or a synthetic splicing sequence. The invention also concerns a host cell and an infectious viral particle comprising such a vector, a method for preparing such a particle and their therapeutic or prophylactic use. The invention further concerns a pharmaceutical composition containing said adenoviral vector, said host cell or said viral particle.

公开(公告)号：EP0988391B1

公开(公告)日：2004-12-15

申请号：EP98928412.0

申请日：1998-06-02

申请人： TRANSGENE S.A.

发明人： MEHTALI, Majid ,  LEROY, Pierre ,  MICHOU, Anne-Isabelle

IPC分类号： C12N15/86 ,  C12N5/10 ,  A61K48/00 ,  C12N15/26 ,  C07K14/55 ,  C12N15/12 ,  C07K14/745

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2830/42 ,  C12N2840/44

摘要： The invention concerns a recombinant adenoviral vector driving from an adenovirus genome at least by deleting all or part of the E1 region, said adenoviral vector comprising an expression cassette of a gene of interest placed under the control of elements necessary for its expression in a host cell or a host organism, said elements required for its expression including at least a splicing sequence. The invention is characterised in that said splicing sequence is derived from a eukaryotic nuclear gene selected among the ovalbumen genes, α or β-globine, collagen and factor VIII of mammals or a synthetic splicing sequence. The invention also concerns a host cell and an infectious viral particle comprising such a vector, a method for preparing such a particle and their therapeutic or prophylactic use. The invention further concerns a pharmaceutical composition containing said adenoviral vector, said host cell or said viral particle.

公开(公告)号：EP0784693A1

公开(公告)日：1997-07-23

申请号：EP96926455.0

申请日：1996-07-24

申请人： TRANSGENE S.A.

发明人： MEHTALI, Majid ,  LUSKY, Monika ,  RITTNER, Karola

IPC分类号： C12N15 ,  A61K35 ,  A61K48 ,  C12N5 ,  C12N7

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N7/00 ,  C12N2710/10343 ,  C12N2710/10352 ,  C12N2830/006 ,  C12N2840/20

摘要： Novel viral vectors in which the expression of viral genes is regulated in such a way that it is functional in a complementation cell and non-functional in a host cell, as well as viral particles and host cells containing said novel vectors, are disclosed. A complementation cell including a viral gene expression regulator, and a method for preparing infectious viral particles, are also disclosed. Finally, a pharmaceutical composition containing said vectors, and the therapeutical use thereof, are disclosed.

公开(公告)号：EP0682712A1

公开(公告)日：1995-11-22

申请号：EP95903830.0

申请日：1994-12-13

申请人： TRANSGENE S.A.

发明人： MEHTALI, Majid ,  LEISSNER, Philippe

IPC分类号： C12N15 ,  A61K35 ,  A61K38 ,  A61K48 ,  A61P31 ,  C07K14 ,  C12N5

CPC分类号： A61K38/21 ,  A61K48/00 ,  C07K14/555 ,  C12N15/86 ,  C12N2740/13043 ,  C12N2740/16322

摘要： A cassette for the expression of a human IFN gene placed under the control of HIV virus-inducible elements, a vector and a cell containing said cassette, therapeutical uses thereof, and a pharmaceutical composition for treating or preventing HIV-related infections, are disclosed.

公开(公告)号：EP0842279A2

公开(公告)日：1998-05-20

申请号：EP96927107.0

申请日：1996-07-30

申请人： TRANSGENE S.A.

发明人： LUSKY, Monika ,  MEHTALI, Majid

IPC分类号： C12N15 ,  A61K35 ,  A61K48 ,  C12N5 ,  C12N7 ,  C12P21 ,  C12R1

CPC分类号： C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/10352 ,  C12N2800/30

摘要： Novel helper vectors are provided for complementing defective recombinant viral vectors, characterised in that they are provided with recombination sequences recognised by a recombinase. A complementation cell expressing the recombinase, and a method for preparing recombinant viral vectors as infectious viral particles for transferring and expressing genes of interest in a host organism or cell, are also provided. The invention is particularly suitable for use in gene therapy, especially in humans.

公开(公告)号：EP0682708A1

公开(公告)日：1995-11-22

申请号：EP95903829.0

申请日：1994-12-13

申请人： TRANSGENE S.A.

发明人： MEHTALI, Majid ,  GUSS, Tania

IPC分类号： C07K14 ,  C12N15 ,  A61K38 ,  A61K48

CPC分类号： C12N15/86 ,  A61K38/00 ,  A61K48/00 ,  C07K14/005 ,  C12N2740/13043 ,  C12N2740/16322 ,  C12N2830/002 ,  C12N2830/60 ,  C12N2840/203

摘要： A composition resulting from a combination of trans-dominant variants of two viral proteins from a single virus, and the use thereof as a combination product are disclosed. A vector for expressing the two variants, a eukaryotic cell containing same, and a pharmaceutical composition for treating viral infections, are also disclosed.

公开(公告)号：EP0781344B1

公开(公告)日：2005-11-23

申请号：EP95930578.0

申请日：1995-09-13

申请人： TRANSGENE S.A.

发明人： LEROY, Pierre ,  MEHTALI, Majid

IPC分类号： C12N15/86 ,  A61K48/00 ,  A61K9/00 ,  C12N5/10

CPC分类号： C12N15/86 ,  A61K9/0024 ,  A61K38/00 ,  A61K48/00 ,  C07K16/10 ,  C07K16/3046 ,  C07K2319/00 ,  C12N2710/10343 ,  C12N2740/13043 ,  C12N2840/20 ,  C12N2840/203

摘要： Genetically modified cell implant comprising an exogenous nucleotide sequence coding for all or part of an antibody, method for the preparation of such an implant and its therapeutic use for the treatment or prevention of an acquired disease. The invention also concerns an adenoviral vector for the expression of one or more proteins capable of forming a multimer, viral particles and cells containing the adenoviral vector, a pharmaceutical composition and its therapeutic use.