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公开(公告)号：EP2446033A2
公开(公告)日：2012-05-02
申请号：EP10752168.4
申请日：2010-06-22
CPC分类号： C12Q1/6837 , C12N15/1068 , C40B40/06 , C40B50/04
摘要： A method for identifying one or several molecular structure(s) having a high-affinity for a target of interest, said molecular structure(s) each comprising one nucleotide chain onto which is hybridized at least one PNA-encoded molecule.
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公开(公告)号：EP2446033B1
公开(公告)日：2013-10-23
申请号：EP10752168.4
申请日：2010-06-22
CPC分类号： C12Q1/6837 , C12N15/1068 , C40B40/06 , C40B50/04
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3.发明公开IRREVERSIBLE INHIBITORS USEFUL FOR THE TREATMENT OF KINASE-RELATED PATHOLOGIES 审中-公开不可逆抑制剂来治疗激酶相关疾病
公开(公告)号：EP2483259A1
公开(公告)日：2012-08-08
申请号：EP10760324.3
申请日：2010-09-28
IPC分类号： C07D313/00 , A61K31/335 , A61P35/00
CPC分类号： C07D313/00
摘要： The present invention provides new compounds (I) having a kinase inhibitory activity and useful for treating cancer.
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4.发明授权SYNTHESIS OF RESORCYLIC ACID LACTONES USEFUL AS THERAPEUTIC AGENTS 有权所产生的合成作为合适THERAPEUTICS二羟基苯甲酸内酯的
公开(公告)号：EP2242359B1
公开(公告)日：2016-06-01
申请号：EP09702521.7
申请日：2009-01-15
IPC分类号： A01N31/14 , A61K31/02 , C07D313/00 , C07D405/12 , C07D405/14
CPC分类号： C07D313/00 , A61K31/335 , A61K31/365 , A61K31/4025 , A61K31/435 , A61K31/4453 , A61K31/4523 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D211/14 , C07D225/06 , C07D405/12 , C07D405/14 , Y02P20/55
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公开(公告)号：EP2254880B8
公开(公告)日：2016-09-21
申请号：EP09713314.4
申请日：2009-02-23
发明人： HECK, James , WINSSINGER, Nicolas , CHABALA, John C. , BARLUENGA, Sofia , CHEN, Ruihong , RUBENSTEIN, Allan , YU, Jin-Chen
IPC分类号： C07D313/00 , C07D315/00 , A61K31/365
CPC分类号： C07D313/00
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6.发明公开POCHOXIME CONJUGATES USEFUL FOR THE TREATMENT OF HSP90 RELATED PATHOLOGIES 审中-公开POCHOXIMKONJUGATE为疾病相关的HSP90治疗
公开(公告)号：EP2630132A1
公开(公告)日：2013-08-28
申请号：EP11797116.8
申请日：2011-10-24
IPC分类号： C07D313/00 , C07D495/04 , C07H15/26 , A61K31/335 , A61K31/7048 , A61P35/00
CPC分类号： C07D405/12 , A61K31/4523 , A61K31/454 , A61K31/706 , C07D313/00 , C07D405/14 , C07D495/04 , C07H15/26
摘要： The present invention includes novel derivatives, analogs, and intermediates of the natural products radicicol, pochonins, pochoximes, and their syntheses. The present invention also provides a pharamceutical composition comprising the present compound and the use of the compound as inhibitors of kinases and of the enzyme family known as heat shock protein 90 (HSP90).
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公开(公告)号：EP2254880B1
公开(公告)日：2016-08-17
申请号：EP09713314.4
申请日：2009-02-23
发明人： HECK, James , WINSSINGER, Nicolas , CHABALA, John C. , BARLUENGA, Sofia , CHEN, Ruihong , RUBENSTEIN, Allan , YU, Jin-Chen
IPC分类号： C07D313/00 , C07D315/00 , A61K31/365
CPC分类号： C07D313/00
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