公开(公告)号：EP0745125A1

公开(公告)日：1996-12-04

申请号：EP94924579.0

申请日：1994-08-05

申请人： ZymoGenetics, Inc. ,  University of Washington

发明人： HOLLY, Richard, D. ,  LOK, Si ,  FOSTER, Donald, C. ,  HAGEN, Frederick, S. ,  KAUSHANSKY, Kenneth ,  KUIJPER, Joseph, L. ,  LOFTON-DAY, Catherine ,  OORT, Pieter, J. ,  BURKHEAD, Steven, K.

IPC分类号： A01K67 ,  A61K38 ,  A61P7 ,  C07H21 ,  C07K1 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12N15 ,  C12P21 ,  C12Q1 ,  G01N33 ,  A61K35 ,  C12R1

CPC分类号： G01N33/5055 ,  A61K38/196 ,  C07K14/705 ,  C07K14/715 ,  C12N5/0642 ,  C12N2501/145 ,  C12N2501/22 ,  G01N33/5005 ,  G01N33/5008 ,  G01N33/5088 ,  G01N33/5094

摘要： Hematopoietic proteins and polypeptide fragments thereof are provided, including proteins and polypeptides from mice and humans. Also provided are DNA molecules encoding the proteins and polypeptides, as well as vectors and cells useful in their production. Antibodies that bind to an epitope on the proteins are also provided. The proteins and polypeptides are useful for in vivo and ex vivo therapy, and as reagents for cell culture and investigation of cell proliferation and development.

公开(公告)号：EP1335977A2

公开(公告)日：2003-08-20

申请号：EP01990805.2

申请日：2001-11-15

申请人： ZymoGenetics, Inc.

发明人： LOK, Si ,  HOLLOWAY, James, L.

IPC分类号： C12N15/12 ,  C07K14/705 ,  C12N5/10 ,  C07K16/28 ,  G01N33/53

CPC分类号： C07K14/705

摘要： In mammals, the vomeronasal organ, which detects phermones, resides in a blind ended pouch within the septum of the nose. Vomeronasal organ-derived signals bypass higher cognitive centers and are processed directly in regions of the amygdala and hypothalamus, which have been implicated in the regulation of innate behaviour, reproductive physiology, and other neuroendocrine responses. Zvn2R1 encodes a human vomeronasal receptor.

公开(公告)号：EP0658200A1

公开(公告)日：1995-06-21

申请号：EP93920429.0

申请日：1993-08-30

申请人： ZYMOGENETICS, INC.

发明人： KINDSVOGLE, Wayne, R. ,  JELINEK, Laura, J. ,  SHEPPARD, Paul, O. ,  GRANT, Francis, J. ,  KUIJPER, Joseph, L. ,  FOSTER, Donald, C. ,  LOK, Si ,  O'HARA, Patrick, J.

IPC分类号： G01N33 ,  C07H21 ,  C07K14 ,  C07K16 ,  C12N5 ,  C12N15 ,  C12P21 ,  C12Q1 ,  A61K38

CPC分类号： C07K14/723 ,  A61K38/00 ,  C07K14/72 ,  C07K2319/00 ,  C07K2319/02 ,  C12Q1/66 ,  G01N33/74 ,  G01N2333/605 ,  G01N2333/72

摘要： The present invention provides isolated DNA molecules comprising a DNA segment encoding a glucagon receptor. Also provided are DNA constructs comprising a first DNA segment encoding a glucagon receptor operably linked to additional DNA segments required for the expression of the first DNA segment, as well as host cells containing such DNA constructs. The present invention also provides amethod for detecting the presence of glucagon antagonists, comprising the steps of (a) exposing a compound in the presence of a glucagon agonist to a recombinant glucagon receptor coupled to a response pathway under conditions and for time sufficient to allow binding of the compound to the receptor and an associated response through the pathway, and (b) detecting a reduction in the stimulation of the response pathway resulting from the binding of the compound to the glucagon receptor, relative to the stimulation of the response pathway by the glucagon agonist alone and therefrom determining the presence of a glucagon antagonist.

公开(公告)号：EP1053324B1

公开(公告)日：2006-08-16

申请号：EP99906984.2

申请日：1999-02-12

申请人： ZymoGenetics, Inc.

发明人： SHEPPARD, Paul, O. ,  LOK, Si

IPC分类号： C12N15/12 ,  C07K14/475 ,  C12N5/10 ,  C12N15/62 ,  C07K16/26 ,  A61K38/18 ,  A01K67/027

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  C07K14/59 ,  C12N2799/026

摘要： The present invention relates to polynucleotide and polypeptide molecules for zsig51, a novel member of the cystine knot family of polypeptides. The polypeptides comprise a sequence of amino acid residues that is at least 80 % identical in amino acid sequence to residues 1 through 106 of SEQ ID NO:2. The invention further provides therapeutic and diagnostic methods utilizing the polynucleotides, polypeptides, and antagonists of the polypeptides.

公开(公告)号：EP1117793A2

公开(公告)日：2001-07-25

申请号：EP99953037.1

申请日：1999-10-01

申请人： ZymoGenetics, Inc.

发明人： LOK, Si ,  SHEPPARD, Paul, O.

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K16/18 ,  A61K38/17

CPC分类号： C07K14/4702 ,  A61K38/00 ,  A61K48/00

摘要： Secretory Protein - 48 (Zsig48), polypeptides, polynucleotides encoding said polypeptides, antibodies which specifically bind to Zsig48 and anti-idiotypic antibodies. Zsig48 polypeptides cause leukocytes to proliferate and thus can be used to elevate leukocytes in cancer treatments and in immunosuppressed patients.

公开(公告)号：EP0832209A1

公开(公告)日：1998-04-01

申请号：EP96918107.0

申请日：1996-06-04

申请人： ZymoGenetics, Inc.

发明人： LOK, Si

IPC分类号： C12N15 ,  C12N5 ,  C12P21 ,  C12Q1

CPC分类号： C12N15/1051 ,  C07K2319/02 ,  C07K2319/32 ,  C07K2319/90 ,  C12N15/625 ,  C12Q1/6858

摘要： Expression vectors and methods for cloning amino-terminal signal sequences are disclosed. These vectors and methods are useful tools for selecting, expressing and isolating previously unknown signal sequences. In turn, an orphan signal sequence can be used to clone, identify and isolate the corresponding orphan proteins that the orphan signal sequence directs to the surface of a cell. Using these expression vectors and methods, an orphan protein can be cloned in the absence of a functional assay that detects such protein.

公开(公告)号：EP1276881B1

公开(公告)日：2006-02-22

申请号：EP01928859.6

申请日：2001-04-25

申请人： ZymoGenetics, Inc.

发明人： LOK, Si

IPC分类号： C12N15/66 ,  C12N15/67 ,  C12N15/85 ,  C12P21/02

CPC分类号： C12N15/67

摘要： The increased use of nucleotide sequence data mining techniques has amplified the demand for efficient methods of producing recombinant proteins in eukaryotic cells. A strategy is provided for enhancing the synthesis of recombinant amino acid sequences by polymerizing expression cassettes in vitro before producing recombinant hosts.

公开(公告)号：EP1276881A2

公开(公告)日：2003-01-22

申请号：EP01928859.6

申请日：2001-04-25

申请人： ZymoGenetics, Inc.

发明人： LOK, Si

IPC分类号： C12N15/66 ,  C12N15/67 ,  C12N15/85 ,  C12P21/02

CPC分类号： C12N15/67

摘要： The increased use of nucleotide sequence data mining techniques has amplified the demand for efficient methods of producing recombinant proteins in eukaryotic cells. A strategy is provided for enhancing the synthesis of recombinant amino acid sequences by polymerizing expression cassettes in vitro before producing recombinant hosts.

公开(公告)号：EP1053324A1

公开(公告)日：2000-11-22

申请号：EP99906984.2

申请日：1999-02-12

申请人： ZymoGenetics, Inc.

发明人： SHEPPARD, Paul, O. ,  LOK, Si

IPC分类号： C12N15/12 ,  C07K14/475 ,  C12N5/10 ,  C12N15/62 ,  C07K16/26 ,  A61K38/18 ,  A01K67/027

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  C07K14/59 ,  C12N2799/026

摘要： The present invention relates to polynucleotide and polypeptide molecules for zsig51, a novel member of the cystine knot family of polypeptides. The polypeptides comprise a sequence of amino acid residues that is at least 80 % identical in amino acid sequence to residues 1 through 106 of SEQ ID NO:2. The invention further provides therapeutic and diagnostic methods utilizing the polynucleotides, polypeptides, and antagonists of the polypeptides.

公开(公告)号：EP1009825A1

公开(公告)日：2000-06-21

申请号：EP98911383.2

申请日：1998-02-18

申请人： ZymoGenetics, Inc.

发明人： LOK, Si ,  KHO, Choon, J. ,  JELMBERG, Anna, C. ,  ADAMS, Robyn, L. ,  WHITMORE, Theodore, E. ,  FARRAH, Theresa, M.

IPC分类号： C12N15/12 ,  C07K14/715 ,  C12N15/62 ,  C07K16/28 ,  C07K16/42 ,  C07K19/00 ,  G01N33/50

CPC分类号： C07K14/715 ,  C07K2319/02 ,  Y10S930/12 ,  Y10S930/14

摘要： Novel cytokine receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in kidneys, pancreas, prostate, adrenal cortex and nervous tissue. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of these organs.