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公开(公告)号：EP2832784A1
公开(公告)日：2015-02-04
申请号：EP13769270.3
申请日：2013-03-28
发明人： YAHARA, Kazuyuki , TOEI, Yozo , DOHI, Akihito , TANIKAWA, Yuji
IPC分类号： C08J9/12
CPC分类号： C08J9/142 , C08J9/0042 , C08J9/0061 , C08J9/0066 , C08J9/12 , C08J9/141 , C08J9/26 , C08J2201/026 , C08J2201/0446 , C08J2203/12 , C08J2203/14 , C08J2205/05 , C08J2205/06 , C08J2207/00 , C08J2323/16 , C08J2423/16 , C09K3/1006 , C09K2200/0642
摘要： Provided is a porous body, which is formed of a resin obtained by crosslinking a copolymer of ethylene, an α-olefin, and a non-conjugated diene, wherein porosity of the porous body is in the range of 50 to 95% by volume, strength of the porous body at 50% compression is 300 kPa or less, and compression set (A) under atmosphere at a temperature of 80°C and a relative humidity of 90% is 20% or less.
摘要翻译： 本发明提供一种多孔体，其由将乙烯，α-烯烃和非共轭二烯的共聚物交联而成的树脂形成，其中，多孔体的气孔率为50〜95体积％ 50％压缩时的多孔体的强度为300kPa以下，在温度80℃，相对湿度90％的气氛下的压缩永久变形（A）为20％以下。
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2.发明公开METHODS FOR THE PREPARATION OF CELLULAR HYDROGELS 审中-公开VERFAHREN ZUR HERSTELLUNG VON ZELLIGEN HYDROGELEN
公开(公告)号：EP1401931A4
公开(公告)日：2006-04-26
申请号：EP02734021
申请日：2002-04-18
申请人： NANOSYSTEMS RES INC
发明人： NEDELJKO GVOZDIC
IPC分类号： B29C67/20 , B29K29/00 , C08J9/26 , C08J9/30 , C08F16/06 , C08F116/06 , C08F216/06 , C08J9/28
CPC分类号： C08J9/26 , C08J2201/0446
摘要： What is disclosed herein are physically cross-linked, cellular hydrogels and methods for their preparation. The cellular materials are highly resilient, hydrophilic materials having broad uses. The cellular materials are prepared by the physical crosslinking of frothed polymers and providing materials that have cellular pores provided by the uses of removable materials during the formation of the cellular materials.
摘要翻译： 本文公开的是物理交联的，细胞水凝胶及其制备方法。 多孔材料是具有广泛用途的高弹性亲水材料。 多孔材料通过发泡聚合物的物理交联并通过在形成细胞材料期间使用可移除材料提供的具有细孔的材料来制备。
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3.发明公开
公开(公告)号：EP3129222A1
公开(公告)日：2017-02-15
申请号：EP15777469.6
申请日：2015-04-09
申请人： Cornell University
IPC分类号： B32B15/06
CPC分类号： C08J9/26 , C08J9/08 , C08J9/10 , C08J9/365 , C08J2201/026 , C08J2201/0444 , C08J2201/0446 , C08J2203/02 , C08J2203/04 , C08J2203/10 , C08J2205/05 , C08J2205/06 , C08J2207/00 , C08J2300/26 , C08J2383/04 , F15B15/103
摘要： Soft actuators are fabricated from materials that enable the actuators to be constructed with an open-celled architecture such as an interconnected network of pore elements. The movement of a soft actuator is controlled by manipulating the open-celled architecture, for example inflating/ deflating select portions of the open-celled architecture using a substance such as compressed fluid.
摘要翻译： 柔性致动器由能够使致动器构造成具有开孔结构的材料制成，诸如孔元件的互连网络。 柔性致动器的移动通过操纵开孔结构来控制，例如使用诸如压缩流体的物质来充气/放气开放式结构的选择部分。
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公开(公告)号：EP1812481B1
公开(公告)日：2012-01-11
申请号：EP05851973.7
申请日：2005-11-18
IPC分类号： C08F20/00 , C08G63/02 , A61F2/00 , B32B27/00 , C08G63/08 , C08G81/00 , C08K5/00 , A61L27/42 , C08J9/26
CPC分类号： A61L27/56 , A61L27/18 , A61L27/46 , B33Y70/00 , B33Y80/00 , C08G63/08 , C08G63/60 , C08G2261/126 , C08J9/26 , C08J2201/024 , C08J2201/0446 , C08J2367/06 , C08L67/06
摘要： Poly(propylene fumarate) is copolymerized with poly(caprolactone) diol to produce a block copolymer of poly(propylene fumarate) and poly(caprolactone). The biocompatible and bioresorbable block copolymer of poly(propylene fumarate) and poly(caprolactone) is useful in the fabrication of injectable and in situ hardening scaffolds for tissue and/or skeletal reconstruction. The block copolymer can be crosslinked by redox or photo-initiation, with or without an additional crosslinker. Thus, the copolymer is both self-crosslinkable (without the use of any crosslinkers) and photocrosslinkable (in the presence of photons such as UV light).
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公开(公告)号：EP2291206A2
公开(公告)日：2011-03-09
申请号：EP09750189.4
申请日：2009-05-19
申请人： Orteq B.V.
CPC分类号： C08G18/10 , A61L27/18 , A61L27/56 , A61L27/58 , C08G18/4277 , C08G18/73 , C08G18/82 , C08G2101/00 , C08G2230/00 , C08J9/26 , C08J2201/0446 , C08J2375/04 , C08L75/04 , C08G18/3206
摘要： The present invention provides a polyurethane implant that is porous and degradable, and act as a scaffold for the repair of damaged tissue. Importantly, the implant of the present invention is biocompatible with the degradation products of the implant causing minimal immune or cytotoxic reaction. The present invention also provides for a method of making these biocompatible implants.
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公开(公告)号：EP1948722A4
公开(公告)日：2010-06-30
申请号：EP06804682
申请日：2006-11-06
申请人： PPD MEDITECH
CPC分类号： B32B5/145 , A61L27/18 , A61L27/48 , A61L27/56 , B32B5/22 , B32B27/00 , C08J9/26 , C08J2201/0446 , C08J2205/05 , C08J2371/12 , Y10T428/249953 , Y10T428/249981 , Y10T428/249991 , C08L71/00
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公开(公告)号：EP0532611A1
公开(公告)日：1993-03-24
申请号：EP91910979.0
申请日：1991-06-05
申请人： KABI PHARMACIA AB
发明人： EK, Bo, Ragnar , ERIKSSON, Kjell, Gunnar , NYQVIST, Per, Gustaf, Hakan , RAGNARSSON, Gert, Anders
CPC分类号： C08J9/26 , A61K9/1652 , A61K9/2054 , A61K9/2081 , C08B15/02 , C08J2201/0446 , C08J2301/02 , C08L1/02
摘要： L'invention se rapporte à un procédé de fabrication de particules de cellulose poreuses, qui ont une forme régulière et une capacité de sorption de l'eau de 1,5 à 9 fois leur propre poids, ainsi qu'une masse volumique apparente après tassement inférieure à 0,85 g/ml. Le procédé de fabrication de ces matrices cellulosiques poreuses consiste à traiter mécaniquement la cellulose hydraulisée dans une phase à voie humide. Les matrices celluylosiques ont de préférence une grandeur d'au moins 0,1 mm et une masse volumique apparente après tassement de 0,1 à 0,7 g/ml. Une substance bioactive ou des substances bioactives peuvent être sorbées, précipitées ou sublimées dans la structure poreuse des matrices. Ces matrices peuvent être mélangées avec des médicaments ou avec des granulés contenant des médicaments, afin d'en améliorer la mise en tablettes et les propriétés des tablettes obtenues, et elles peuvent ensuite être comprimées. Des matrices dans lesquelles il est incorporé un médicament peuvent être utilisée pour permettre la compression directe des tablettes.
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公开(公告)号：EP3180390A1
公开(公告)日：2017-06-21
申请号：EP15744854.9
申请日：2015-06-16
发明人： TEASDALE, Ian , WILFERT, Sandra , AIGNER, Tamara , ITURMENDI, Aiztiber , BRUEGGEMANN, Oliver , SCHROEDER, Klaus , OLAWALE, Gbenga , HILDNER, Florian , RIGAU DE LLOBET, Maria
CPC分类号： C08G79/025 , A61L27/18 , A61L27/52 , A61L27/56 , C08G79/02 , C08G2230/00 , C08J9/26 , C08J2201/0446 , C08J2205/10 , C08J2207/10 , C08J2385/02 , C08L85/02
摘要： The invention relates to a polymer for tissue engineering composed of biodegradable polyphosphazenes with photopolymerizable side groups, wherein the side groups of the polyphosphazenes are exclusively formed of amino acids and/or amino acid derivatives, wherein said side groups are bound to the backbone of the polyphosphazene via the amino group of the amino acid, and comprising a spacer bound to the acid group having a carbon chain of length m which comprises a vinyl group at its free end, wherein m = 0 to 10.
摘要翻译： 本发明涉及用于组织工程的聚合物，其由具有可光聚合侧基的生物可降解聚磷腈组成，其中聚磷腈的侧基完全由氨基酸和/或氨基酸衍生物形成，其中所述侧基与聚磷腈的骨架结合 经由氨基酸的氨基基团并且包含与具有长度为m的碳链的酸基团结合的间隔基，所述间隔基团在其自由末端包含乙烯基，其中m = 0至10。
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公开(公告)号：EP2093256A3
公开(公告)日：2009-10-14
申请号：EP09004700.2
申请日：2006-07-28
发明人： Campbell, Phil , Fisher, Gregory W. , Kumta, Prashant , Sipe, David M. , Smith, Jason , Weiss, Lee E.
CPC分类号： C09D11/30 , A61L27/225 , A61L27/50 , C08J3/24 , C08J5/18 , C08J9/0066 , C08J9/26 , C08J2201/024 , C08J2201/0446 , C08J2201/046 , C08J2207/10 , C08J2300/16 , C08J2389/00 , C08L5/00 , C08L89/00 , C09D7/65 , C09D11/08
摘要： Compositions and methods for manufacturing polymers are disclosed. Compositions include novel plastics, including films and shaped forms comprising polymer matrices that are biologically compatible and biodegradable. Such plastics may comprise polymers derived from natural sources. Further, such plastics are useful in biological systems for wound repair, implants, stents, drug encapsulation and delivery, and other applications. The disclosed methods comprise mild manufacturing processes such that various additives, such as biologically active proteins, sugars, lipids, and the like may be incorporated into the polymer matrix without subsequent loss of bioactivity during processing. Additionally, methods of manufacture for controlling mechanical properties, such as elasticity, pliancy, and the porosity of such plastics are disclosed.
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公开(公告)号：EP1948722A2
公开(公告)日：2008-07-30
申请号：EP06804682.0
申请日：2006-11-06
申请人： PPD Meditech
CPC分类号： B32B5/145 , A61L27/18 , A61L27/48 , A61L27/56 , B32B5/22 , B32B27/00 , C08J9/26 , C08J2201/0446 , C08J2205/05 , C08J2371/12 , Y10T428/249953 , Y10T428/249981 , Y10T428/249991 , C08L71/00
摘要： A method for fabricating a porous structure from a first material. The method comprises the acts of mixing the first material with a second material to form a mixture, the first material having a melting point which is lower than the second material, heating the mixture under pressure to a temperature between a melting point of the first material and a melting point of the second material, cooling the molten mixture until it hardens and removing the second material from the first material. The method may also include a subsequent annealing step. There is also described a material suitable for implant, illustratively vertebral or spinal implants, comprising a rigid biocompatible polymer such as PEEK comprising a plurality of interconnected pores. The polymer illustratively has a porosity of between 50% and 85% by volume and in a particular embodiment is able to withstand pressures of up to 20 MPa. The porous PEEK material may also have a minimum thickness in any dimension of one (1 ) inch.
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