Compounds for Dual Photodiagnosis and Therapy
    7.
    发明公开
    Compounds for Dual Photodiagnosis and Therapy 审中-公开
    Verbindungen zur Fotodiagnose und Therapie

    公开(公告)号:EP2270107A1

    公开(公告)日:2011-01-05

    申请号:EP10184629.3

    申请日:2004-10-07

    申请人: Mallinckrodt Inc.

    IPC分类号: C09B47/00 A61K49/00

    摘要: The invention discloses compounds and compositions for dual phototherapy and combined therapy and diagnosis of tumors and other lesions. The compounds have a Dye that, when photoactivated, operates via Type I and/or Type II mechanisms. Other Dye or azide components may operate by the same or different mechanisms. Selection of particular components in a compound, and formulation of the compound(s) in a composition permit different activation wavelengths to be used for different therapies. A targeting moiety may be added to the compound or composition so that the Dye locates at a particular site, such as a hormone-sensitive tumor, for diagnosis and/or treatment. The compounds and compositions may be incorporated within liposomes.

    摘要翻译: 本发明公开了用于双光疗法和组合治疗和诊断肿瘤和其他病变的化合物和组合物。 化合物具有染料,当光活化时,它们通过I型和/或II型机制进行操作。 其它染料或叠氮化物组分可以通过相同或不同的机理操作。 选择化合物中的特定组分以及组合物中化合物的配制允许不同的活化波长用于不同的疗法。 可以将靶向部分加入到化合物或组合物中,使得染料位于特定部位,例如激素敏感性肿瘤,用于诊断和/或治疗。 化合物和组合物可以掺入脂质体中。