公开(公告)号：EP2606165A4

公开(公告)日：2014-02-26

申请号：EP11817602

申请日：2011-08-16

申请人： MOUNT SINAI HOSPITAL CORP

发明人： JARVI KEITH ,  DIAMANDIS ELEFTHERIOS P ,  DRABOVICH ANDREI

IPC分类号： C40B40/10 ,  C12Q1/68 ,  C40B30/04 ,  G01N33/48 ,  G01N33/53 ,  G01N33/68

CPC分类号： G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/68 ,  G01N33/689 ,  G01N2333/705 ,  G01N2333/78 ,  G01N2800/34 ,  G01N2800/342 ,  G01N2800/367

摘要： Methods for detecting urogenital conditions or urogenital status in a subject are described comprising measuring urogenital markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for urogenital conditions, and kits for carrying out the methods of the invention. The invention also contemplates therapeutic applications for urogenital conditions employing urogenital markers, polynucleotides encoding the markers, and/or binding agents for the markers.

公开(公告)号：EP2520648A4

公开(公告)日：2013-11-20

申请号：EP10841044

申请日：2010-12-28

申请人： KYOWA HAKKO KIRIN CO LTD

发明人： KANEKO ETSUJI ,  SASAKI YUKA ,  MORI KATSUHIRO ,  KANDA YUTAKA ,  SATOH MITSUO

IPC分类号： C12N15/09 ,  A61K39/395 ,  A61P13/12 ,  A61P37/02 ,  C07K16/42 ,  C07K16/46 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  G01N33/53

CPC分类号： C07K16/4283 ,  C07K2317/34 ,  C07K2317/92 ,  G01N2800/34

摘要： An object of the present invention is to provide a monoclonal antibody which is effective for diagnosing IgA nephropathy and specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound. According to the present invention, it is possible to provide a monoclonal antibody or an antibody fragment thereof that specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound, to provide a diagnostic agent using the antibody or the antibody fragment thereof, and to provide a therapeutic agent comprising the antibody or the antibody fragment thereof as an active ingredient.

摘要翻译： 本发明的目的是提供一种单克隆抗体，该单克隆抗体对于诊断IgA肾病是有效的，并特异性识别和结合由包含丝氨酸/苏氨酸连接的糖链的免疫球蛋白A1的重链基因编码的多肽的铰链区 半乳糖不结合。 根据本发明，可以提供特异性识别并结合由包含丝氨酸/苏氨酸连接的糖链的免疫球蛋白A1的重链基因编码的多肽的铰链区的单克隆抗体或其抗体片段 使用抗体或其抗体片段提供诊断剂，并提供包含抗体或其抗体片段的治疗剂作为活性成分。

公开(公告)号：EP2216023A4

公开(公告)日：2013-03-13

申请号：EP08851020

申请日：2008-11-14

申请人： TAKEDA PHARMACEUTICAL

发明人： MATSUMOTO TAKAHIRO ,  NAGAMIYA HIROYUKI ,  MAEZAKI HIRONOBU ,  KUSUMOTO TOMOKAZU ,  YOSHIKAWA KYOKO ,  FURUKAWA HIDEKI ,  KAMO IZUMI

IPC分类号： A61K31/4545 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/00 ,  A61P1/00 ,  A61P3/04 ,  A61P13/02 ,  A61P13/10 ,  A61P43/00 ,  C07D471/04 ,  G01N33/15 ,  G01N33/50 ,  G01N33/68

CPC分类号： A61K31/5377 ,  A61K31/4545 ,  A61K31/55 ,  C07D471/04 ,  G01N33/5088 ,  G01N33/6893 ,  G01N2800/34

公开(公告)号：EP2462447A4

公开(公告)日：2013-01-30

申请号：EP10807276

申请日：2010-08-06

申请人： RULES BASED MEDICINE INC

发明人： SPAIN MICHAEL D ,  MAPES JAMES P ,  LABRIE SAMUEL T ,  MCDADE RALPH L ,  EISINGER DOMINIC ,  BALLARD KARRI L

IPC分类号： G01N33/48 ,  G01N33/53 ,  G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/5302 ,  G01N33/566 ,  G01N2333/47 ,  G01N2333/4703 ,  G01N2333/4706 ,  G01N2333/4725 ,  G01N2333/4727 ,  G01N2333/475 ,  G01N2333/52 ,  G01N2333/70503 ,  G01N2333/70539 ,  G01N2333/765 ,  G01N2333/775 ,  G01N2333/8139 ,  G01N2333/8146 ,  G01N2333/82 ,  G01N2333/91177 ,  G01N2800/34 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60 ,  Y10T436/147777

摘要： Methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.

公开(公告)号：EP2462436A1

公开(公告)日：2012-06-13

申请号：EP10807271.1

申请日：2010-08-06

申请人： Rules-Based Medicine, Inc.

发明人： SPAIN, Michael, D. ,  MAPES, James, P. ,  LABRIE, Samuel ,  MCDADE, Ralph ,  EISINGER, Dominic ,  BALLARD, Karri

IPC分类号： G01N33/48 ,  G01N33/53

CPC分类号： G01N33/6893 ,  G01N33/5302 ,  G01N33/566 ,  G01N2333/47 ,  G01N2333/4703 ,  G01N2333/4706 ,  G01N2333/4725 ,  G01N2333/4727 ,  G01N2333/475 ,  G01N2333/52 ,  G01N2333/70503 ,  G01N2333/70539 ,  G01N2333/765 ,  G01N2333/775 ,  G01N2333/8139 ,  G01N2333/8146 ,  G01N2333/82 ,  G01N2333/91177 ,  G01N2800/34 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60 ,  Y10T436/147777

摘要： Methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney transplant rejection or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.

公开(公告)号：EP2188632A4

公开(公告)日：2010-11-10

申请号：EP08799385

申请日：2008-09-10

申请人： BECTON DICKINSON CO

发明人： TYNAN KATHERINE ,  SCHOOLNIK GARY

IPC分类号： G01N33/569 ,  G01N33/558

CPC分类号： G01N33/56911 ,  G01N2333/335 ,  G01N2333/40 ,  G01N2333/44 ,  G01N2800/34 ,  G01N2800/36

公开(公告)号：EP2035574A1

公开(公告)日：2009-03-18

申请号：EP07725942.2

申请日：2007-06-11

申请人： Bayer HealthCare AG

发明人： GOLZ, Stefan ,  BRÜGGEMEIER, Ulf ,  GEERTS, Andreas

IPC分类号： C12Q1/37 ,  G01N33/574

CPC分类号： C12Q1/37 ,  G01N33/574 ,  G01N2500/00 ,  G01N2800/34

摘要： The invention provides a human APEH which is associated with the cardiovascular diseases, cancer, inflammation, hematological diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, inflammation, hematological diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of APEH as well as pharmaceutical compositions comprising such compounds.

公开(公告)号：EP1667630A4

公开(公告)日：2008-07-23

申请号：EP04783287

申请日：2004-09-07

申请人： UNIV TEXAS

发明人： AL-HENDY AYMAN

IPC分类号： C12Q1/68 ,  A61K20060101 ,  A61K39/395

CPC分类号： C12Q1/6883 ,  C12Q1/48 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5044 ,  G01N33/5091 ,  G01N33/57442 ,  G01N33/6893 ,  G01N2800/34 ,  G01N2800/36 ,  G01N2800/364 ,  G01N2800/368

公开(公告)号：EP1075486A1

公开(公告)日：2001-02-14

申请号：EP99921690.6

申请日：1999-05-06

申请人： DUKE UNIVERSITY

发明人： SCHWINN, Debra, A.

IPC分类号： C07H21/04 ,  C12N15/85 ,  C07K14/00 ,  C07K16/00 ,  A61K48/00 ,  C12Q1/68

CPC分类号： G01N33/9433 ,  C07K14/70571 ,  C12Q1/6883 ,  G01N2500/04 ,  G01N2800/34

摘要： The present invention relates to bladder and lower urinary tract syndromes, particularly, irrative symptoms, and to a method of treating same using α1d-adrenergic receptor (α1dAR) antagonists. The invention further relates to a method of screening compounds for their ability to serve as α1dAR selective antagonists.

公开(公告)号：EP0810874A1

公开(公告)日：1997-12-10

申请号：EP96936963.0

申请日：1996-11-01

申请人： Getzenberg, Robert H. ,  Bahnson, Robert R.

发明人： Getzenberg, Robert H. ,  Bahnson, Robert R.

IPC分类号： C12N15 ,  A61K35 ,  A61K39 ,  A61K48 ,  A61P13 ,  A61P15 ,  C07K14 ,  C07K16 ,  C12N5 ,  C12P21 ,  C12Q1 ,  G01N33 ,  A61K38

CPC分类号： G01N33/6872 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  G01N33/57407 ,  G01N33/57488 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/34

摘要： Nuclear matrix proteins (NMPs) which are characterized by a defined expression in bladder tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy, and treating cell proliferative disorders of the bladder. Also provided are substantially purified polypeptides and polypeptide sequences encoding the NMPs of the invention.