摘要:
Described herein are methods of syntheses and therapeutic uses of covalently modified peptides and/or proteins. The covalently modified peptides and/or proteins allow for improved pharmaceutical properties of peptide and protein-based therapeutics.
摘要:
A process to produce a dispersion comprising feeding ethylcellulose polymer and a dispersant into a melt and mix zone of an extruder wherein the ethylcellulose polymer and dispersant are melted and mixed together to form a melt; conveying the melt to an emulsification zone of the extruder in which the temperature and pressure are controlled; feeding a base and water into the emulsification zone wherein the melt is dispersed to form a high internal phase emulsion; conveying the emulsion to a dilution and cooling zone of the extruder; and feeding water into the dilution and cooling zone to dilute the high internal phase emulsion thereby forming an aqueous dispersion is provided.
摘要:
The palatability of a non-starch water-soluble polysaccharide (A) can be improved by at least partially coating the non-starch water-soluble polysaccharide (A) with a methylcellulose (B) having anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups, with the proviso that the non-starch water-soluble polysaccharide (A) is different from said methylcellulose (B).
摘要:
A coating composition may include kaolin having a shape factor less than about 70 and calcium carbonate, wherein less than about 90% by weight and greater than about 60% by weight of particles of the calcium carbonate have an equivalent spherical diameter (esd) less than 2 microns. The coating composition may include a thickener present in an amount ranging from about 0.1% to about 0.9% by active dry weight of the composition. A coating composition may include kaolin having a shape factor less than about 70 and calcium carbonate having a mean particle size (d50) of at least about 2.4 microns and a steepness factor of at least about 30. The coating composition may be a paper basecoat composition or a paperboard basecoat composition. A paper or paperboard product may include the coating composition on at least one surface of the paper product or paperboard product.
摘要:
A liquid composition comprises an organic diluent and at least one cellulose ether having anhydroglucose units joined by 1-4 linkages and having methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that hydroxyl groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.29 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group. The liquid composition can be used for preparing a solid dispersion of an active ingredient in a cellulose ether.
摘要:
A method of improving a strength property of a sheet-formed fibrous material formed from an aqueous slurry of cellulose fiber, comprising coating at least one face of the material with a coating formulation comprising a or consisting of polysaccharide containing at least two carboxylic groups and low molecular weight organic mono-, di- or poly-carboxylic acid in an aqueous carrier, keeping the coated face at a temperature of 50 °C or more for a time sufficient to obtain the desired improvement including drying of the material.
摘要:
An edible film useful for packaging food additives is disclosed. The film generally includes an edible film-forming resin, a plasticizer, a compatibilizer, and optional secondary additives. The resulting edible film has favorable heat seal properties, being able to form an acceptable heat seal over temperature ranges of at least about 10°C.
摘要:
An edible, hardenable coating composition is disclosed which comprises high levels of low viscosity propylene glycol alginate and which may additionally contain a surfactant, a filler, a pigment, and optionally a small amount of a secondary film former and/or a strengthening polymer. The coating composition of the present invention may be applied to pharmaceutical and veterinary solid dosage forms, confectionery, seeds, animal feed, fertilizers, pesticide tablets, and foods and provides an elegant prompt release coating which does not retard the release of active ingredients from the coated substrate.