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公开(公告)号：EP4457346A1
公开(公告)日：2024-11-06
申请号：EP22915046.1
申请日：2022-12-29
发明人： YANG, Liu , JIANG, Wenqing , FANG, Lei
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公开(公告)号：EP4455165A1
公开(公告)日：2024-10-30
申请号：EP22909417.2
申请日：2022-09-23
申请人： EXCELMAB INC.
发明人： ZHANG, Wenjun , LI, Feng , LIU, Min , PAN, Zhihao , QIN, Luying , CAO, Guangcan
IPC分类号： C07K16/46 , C12N15/13 , A61K39/395 , C07K16/00 , A61P27/16
摘要： Provided herein is a bispecific antibody and the use thereof. The bispecific antibody comprises an antibody or antibody fragment; the antibody or the antibody fragment is a bispecific antibody or an antibody fragment comprising a first heavy chain, a first light chain, a second heavy chain, and a second light chain; the first Fab region comprises the first heavy chain and the first light chain; the second Fab region comprises the second heavy chain and the second light chain; and a variety of mutations are introduced in the first Fab region and the second Fab region. By means of performing amino acid size and charge mutations on amino acid residues at a heavy chain CH1 and light chain CL interface of the antibody or the antibody fragment, the correct pairing of heavy/light chains targeting different antigens is enhanced, the binding activity to specific antigens is maintained, mismatches are reduced, the binding specificity is improved, and the yield of a target product is improved.
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公开(公告)号：EP4455163A1
公开(公告)日：2024-10-30
申请号：EP22911263.6
申请日：2022-12-21
发明人： HOSOGUCHI, Kensaku , HARA, Ai , MASUDA, Souta , TAKAGI, Misato , NAMBU, Shusuke , SATO, Kumi
IPC分类号： C07K16/28 , A61K39/395 , A61P17/00 , A61P37/08 , B01J20/281 , C12N15/13 , C12P21/08 , G01N30/02 , G01N30/88
摘要： In one non-limiting embodiment, the present disclosure provides product variants of nemolizumab (antibody variants), particularly product variants with lower biological activity than nemolizumab. The present disclosure also provides nemolizumab-containing compositions that comprise the variants, methods for reducing the variants, and methods for analyzing the variants.
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公开(公告)号：EP4453035A1
公开(公告)日：2024-10-30
申请号：EP22910125.8
申请日：2022-12-22
发明人： YANG, Yongfei , CAO, Shuzhen , ZHANG, Jing , SHAO, Zhe , JIANG, Xueyuan
IPC分类号： C07K16/28 , C12N15/13 , A61K39/395 , A61K47/68 , A61P35/00
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公开(公告)号：EP4453030A1
公开(公告)日：2024-10-30
申请号：EP22910231.4
申请日：2022-12-23
申请人： Inmagene Pte. Ltd.
发明人： LEI, Run , GUO, Chongtian , FAN, Pengcheng , XU, Zhihao , SUN, Qiang , WANG, Jonathan Jian
IPC分类号： C07K16/24 , C07K16/46 , C12N15/13 , C12N15/62 , C12N15/64 , C12N15/85 , C12N5/0783 , A61K39/395 , A61P37/00 , A61P35/00
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公开(公告)号：EP4436996A1
公开(公告)日：2024-10-02
申请号：EP21965065.2
申请日：2021-11-24
发明人： HAN, Zhaozhong , PAN, Hongya
IPC分类号： C07K16/22 , C12N15/13 , A61K39/395 , A61P35/00
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公开(公告)号：EP4170021B1
公开(公告)日：2024-09-25
申请号：EP21870556.4
申请日：2021-12-03
IPC分类号： C12N5/20 , C12N15/13 , C07K16/28 , G01N33/74 , G01N33/58 , G01N33/577 , C07K16/12 , G01N33/558
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公开(公告)号：EP4428156A1
公开(公告)日：2024-09-11
申请号：EP22900650.7
申请日：2022-12-02
发明人： FU, Yayuan , YOU, Shumei , YIN, Bowei , CAO, Zhuoxiao , TANG, Renhong , REN, Jinsheng
IPC分类号： C07K16/28 , A61P35/00 , A61K39/395 , C12N15/13
CPC分类号： C07K16/00 , A61K39/395 , C07K16/28 , A61P35/00
摘要： An antibody, or an antigen-binding fragment of same, specifically binding to a BCMA, a nucleic acid encoding same, an expression vector and an expression cell thereof, a preparation method therefor, a pharmaceutical composition thereof, and the use thereof in treating a disease, for example, the use thereof in treating a tumour.
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公开(公告)号：EP4423138A1
公开(公告)日：2024-09-04
申请号：EP22886052.4
申请日：2022-10-27
申请人： Adagene Pte. Ltd.
发明人： LUO, Peter Peizhi , LI, Yan , CAI, Bin , SHI, Jianfeng , XU, Jiangchun , NGUYEN, Aaron , ZHENG, Songmao , LIU, Guizhong , DAI, Zhengxi , DU, Fangyong
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