公开(公告)号：EP4437344A1

公开(公告)日：2024-10-02

申请号：EP22818727.4

申请日：2022-11-18

Applicant: F. Hoffmann-La Roche AG

Inventor： LARIVIERE, Laurent ,  SCHLOTHAUER, Tilman ,  SPICK, Christian ,  ZWICK, Adrian

IPC: G01N33/543 ,  G01N33/68 ,  G01N21/552

CPC classification number: G01N33/54373 ,  G01N33/6854 ,  C07K2317/3120130101 ,  C07K2317/9220130101 ,  G01N21/553 ,  C07K2317/3520130101 ,  C07K16/46 ,  C07K2317/6420130101 ,  C07K16/18 ,  C07K16/2881

公开(公告)号：EP4436996A1

公开(公告)日：2024-10-02

申请号：EP21965065.2

申请日：2021-11-24

Applicant: Linno Pharmaceuticals Inc.

Inventor： HAN, Zhaozhong ,  PAN, Hongya

IPC: C07K16/22 ,  C12N15/13 ,  A61K39/395 ,  A61P35/00

CPC classification number: C07K16/22 ,  A61P35/00 ,  C07K2317/56920130101 ,  C07K2317/2220130101 ,  C07K2317/6420130101 ,  C07K2317/2420130101 ,  C07K2317/7320130101 ,  C07K2317/7620130101 ,  C07K2317/3520130101

公开(公告)号：EP4436669A1

公开(公告)日：2024-10-02

申请号：EP22817370.4

申请日：2022-11-21

Applicant: Janssen Biotech, Inc.

Inventor： DIEM, Michael ,  HUANG, Chichi ,  LUO, Jinquan ,  TEPLYAKOV, Alexey ,  BOUCHER, Lauren ,  FELDKAMP, Michael ,  ARMSTRONG, Anthony ,  NANDA, Hirsh ,  MAHAN, Andrew David ,  GUNAWARDENA, Harsha Prithviraj ,  CHOWDHURY, Partha ,  POLTASH, Michael Lawrence ,  PRINSLOW, Elisabeth Geyer

IPC: A61P35/00 ,  C07K16/28 ,  C07K16/46

CPC classification number: C07K2317/3120130101 ,  C07K16/2809 ,  C07K2317/62220130101 ,  C07K16/468 ,  C07K2317/5520130101 ,  C07K2317/5620130101 ,  C07K2317/6420130101 ,  C07K16/2878 ,  A61P35/00 ,  A61K2039/50520130101 ,  C07K2317/62420130101 ,  C07K2317/9420130101

公开(公告)号：EP4402167A1

公开(公告)日：2024-07-24

申请号：EP22783640.0

申请日：2022-09-15

Applicant: Cotropia, Joseph ,  Chandra, Gaurav

Inventor： Cotropia, Joseph ,  Chandra, Gaurav

IPC: C07K16/10 ,  A61P31/18 ,  A61K39/395

CPC classification number: C07K16/1063 ,  A61P31/18 ,  C07K2317/2120130101 ,  C07K2317/56920130101 ,  C07K2317/7620130101 ,  C07K2317/9220130101 ,  C07K2317/6420130101

公开(公告)号：EP4353819A3

公开(公告)日：2024-07-17

申请号：EP23218163.6

申请日：2005-07-22

Applicant: Erasmus University Medical Center Rotterdam ,  Craig, Roger Kingdon

Inventor： GROSVELD, Franklin G. ,  JANSSENS, Richard W. ,  DRABEK, Dubravka ,  CRAIG, Roger Kingdon

IPC: C07K16/00 ,  A01K67/027 ,  C12N5/10

CPC classification number: C07K16/00 ,  C07K16/1054 ,  C07K16/1063 ,  C07K16/1232 ,  C07K2317/2220130101 ,  C07K2317/3120130101 ,  C07K2317/5320130101 ,  C07K2317/56920130101 ,  C07K2319/0020130101 ,  C07K2317/6420130101 ,  C07K16/241 ,  A61P1/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P25/00 ,  A61P25/28 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P33/00 ,  A61P35/00 ,  A61P35/02 ,  A61P3/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/04 ,  A61P37/06 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P3/10 ,  C07K16/30 ,  C07K2319/7320130101

Abstract: The present invention relates to the manufacture of a diverse repertoire of functional heavy chain-only antibodies that undergo affinity maturation, and uses thereof. The invention also relates to the manufacture and use of a diverse repertoire of class-specific heavy chain-only antibodies and to the manufacture and use of multivalent polypeptide complexes with antibody heavy chain functionality, preferably antibody heavy chain binding functionality, constant region effector activity and, optionally, additional effector functions.
The present invention also relates to a method of generation of fully functional heavy chain-only antibodies in transgenic mice in response to antigen challenge. In particular, the present invention relates to a method for the generation of human antigen-specific, high affinity, heavy chain-only antibodies of any class, or mixture of classes and the isolation and expression of fully functional VH antigen-binding domains.

公开(公告)号：EP4367144A1

公开(公告)日：2024-05-15

申请号：EP22838601.7

申请日：2022-07-08

Applicant: Orionis Biosciences, Inc. ,  Orionis Biosciences BV

Inventor： KLEY, Nikolai ,  DEPLA, Erik ,  WAUMAN, Joris ,  NAKUCI, Enkeleda ,  HO, Yen-ching ,  KLEY, Alexander, Lee

IPC: C07K16/28 ,  A61K38/17 ,  A61P31/00 ,  A61P35/00 ,  C07K14/47

CPC classification number: A61P31/00 ,  A61P35/00 ,  C07K2319/3020130101 ,  C07K2317/5220130101 ,  C07K2317/7120130101 ,  C07K2317/6420130101 ,  C07K2317/56920130101 ,  C07K16/2815 ,  C07K2319/0020130101 ,  C07K2317/3520130101 ,  C07K2317/9220130101 ,  C07K14/545 ,  A61K39/39

公开(公告)号：EP4438614A1

公开(公告)日：2024-10-02

申请号：EP23315074.7

申请日：2023-03-31

Applicant: Sanofi

Inventor： The designation of the inventor has not yet been filed

IPC: C07K1/22 ,  C07K16/28

CPC classification number: C07K1/22 ,  C07K16/2803 ,  C07K16/2866 ,  C07K2317/3120130101 ,  C07K2317/5520130101 ,  C07K2317/1020130101 ,  C07K2317/5220130101 ,  C07K2317/6420130101

Abstract: The invention relates to a method of purifying a heteromultimeric Fc domain-containing polypeptide, wherein the method comprises the following steps in the indicated order: providing a sample comprising the heteromultimeric Fc domain-containing polypeptide and one or more mispaired variants thereof; contacting a protein A chromatography matrix with the sample and binding the heteromultimeric Fc domain-containing polypeptide to the protein A chromatography matrix; contacting the protein A chromatography matrix with a wash solution, wherein the wash solution comprises octanoate; contacting the protein A chromatography matrix with an elution solution; and collecting an eluate comprising the heteromultimeric Fc domain-containing polypeptide. The invention further relates to the use of a buffer in said method, to a kit for performing said method, and to an eluate obtained by said method.

公开(公告)号：EP3882275B1

公开(公告)日：2024-09-18

申请号：EP19853809.2

申请日：2019-08-30

IPC: C07K16/46 ,  C12N15/13 ,  G01N33/68 ,  A61K39/395 ,  A61P35/00 ,  A61P35/02 ,  C07K16/28 ,  G01N33/74 ,  A61K39/00 ,  C07K16/22

CPC classification number: A61P35/00 ,  A61P35/02 ,  A61K2039/50520130101 ,  C07K16/22 ,  C07K16/2818 ,  C07K2317/2420130101 ,  C07K2317/3120130101 ,  C07K2317/9220130101 ,  C07K2317/6420130101 ,  C07K2317/62220130101 ,  C07K2317/7020130101 ,  C07K2317/7320130101 ,  C07K2317/7620130101 ,  C07K2319/0020130101 ,  G01N2333/47520130101 ,  G01N2333/7059620130101 ,  G01N33/74

公开(公告)号：EP4426433A1

公开(公告)日：2024-09-11

申请号：EP22803077.1

申请日：2022-11-03

Applicant: Affimed GmbH

Inventor： KOCH, Joachim ,  PAHL, Jens ,  ROSS, Thorsten ,  SIEGLER, Jana-Julia ,  DULAT, Holger

IPC: A61P35/00 ,  A61P35/02 ,  C07K16/28

CPC classification number: C07K16/28 ,  C07K16/283 ,  C07K16/2866 ,  C07K2317/3120130101 ,  C07K2317/3320130101 ,  C07K2317/9220130101 ,  C07K2317/62220130101 ,  A61P35/00 ,  A61P35/02 ,  C07K2317/73220130101 ,  C07K2317/7320130101 ,  C07K2317/7020130101 ,  C07K2317/52620130101 ,  A61K2039/50520130101 ,  C07K2317/6420130101

公开(公告)号：EP4413999A3

公开(公告)日：2024-08-28

申请号：EP24167685.7

申请日：2017-05-26

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services

Inventor： CHIEN, Christopher D. ,  FRY, Terry J.

IPC: C07K16/28 ,  A61K38/00 ,  A61K39/395 ,  A61K39/00 ,  A61P35/00

CPC classification number: A61K38/00 ,  A61K39/395 ,  A61K2300/0020130101 ,  C07K2317/2420130101 ,  C07K2317/5320130101 ,  C07K2317/62220130101 ,  C07K2317/6420130101 ,  C07K16/2863 ,  A61P35/00 ,  A61K39/464411 ,  A61K2239/3120230501 ,  A61K2239/4820230501 ,  A61K2239/3820230501 ,  A61K39/4631 ,  A61K39/4611

Abstract: An embodiment of the invention provides a chimeric antigen receptor (CAR) comprising an antigen binding domain specific for FLT3, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of a proliferative disorder, e.g., cancer, in a mammal and methods of treating or preventing a proliferative disorder, e.g., cancer, in a mammal are also disclosed.