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91.发明授权
公开(公告)号：EP0910415B1
公开(公告)日：2004-05-12
申请号：EP97928258.9
申请日：1997-06-18
发明人： BANDIERA, Tiziano , FANCELLI, Daniele , CARUSO, Michele , LANSEN, Jacqueline , SUARATO, Antonino
IPC分类号： A61K49/00 , C07H15/252 , C07D295/185 , C07D295/26 , C07D295/104
CPC分类号： C07D295/185 , A61K49/06 , C07C225/24 , C07C2603/44 , C07D295/112 , C07D295/26 , C07H15/252
摘要： Compounds of formula (A), wherein R1, R2, R3, Y and Z are organic substituents, are useful in the diagnosis of amyloidosis; some of the compounds of formula (A) are novel. Processes for their preparation, and pharmaceutical compositions containing them are also described.
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公开(公告)号：EP1406889A2
公开(公告)日：2004-04-14
申请号：EP02784844.9
申请日：2002-07-03
发明人： MOLL, Juergen , KNAPP, Stefan , DALVIT, Claudio , TROSSET, Jean-Yves , SUNDSTROM, Michael , MANTEGANI, Sergio
IPC分类号： C07D307/52 , C07D333/22 , C07D307/66 , C07D307/68 , C07D333/38 , C07D333/28 , C07D271/113 , C07D261/14 , C07D261/08 , C07D277/32 , C07D277/84 , C07D409/14 , C07D405/14 , C07D405/12
CPC分类号： C07D271/113 , A61K31/00 , C07D261/08 , C07D261/14 , C07D277/32 , C07D277/84 , C07D307/52 , C07D307/66 , C07D307/68 , C07D333/22 , C07D333/28 , C07D333/38 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D513/04
摘要： A compound of formula (I) is provided which is able to interact with β-catenin/TCF-4 binding site, having a structure essentially equivalent to a pharmacophore (IA), as herein described.
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93.发明公开ESSENTIAL N-3 FATTY ACIDS IN CARDIAC INSUFFICIENCY AND HEART FAILURE THERAPY 审中-公开ESSENTIAL N-3脂肪酸心力衰竭心力衰竭的治疗和方法
公开(公告)号：EP1365841A1
公开(公告)日：2003-12-03
申请号：EP02715455.8
申请日：2002-01-16
IPC分类号： A61P9/00
CPC分类号： A61K9/4858 , A61K31/23 , A61K31/355 , A61K45/06 , A61K2300/00
摘要： The present invention concerns a method of therapeutic prevention and treatment of a heart disease chosen from cardiac insufficiency and heart failure including the administration of an essential fatty acid containing a mixture of eicosapentaenoic acid ethyl ester (EPA) and docosahexaenoic acid ethyl ester (DHA), either alone or in combination with another therapeutic agent.
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公开(公告)号：EP1324983A1
公开(公告)日：2003-07-09
申请号：EP01951593.1
申请日：2001-06-14
发明人： BERIA, Italo , COZZI, Paolo , MONGELLI, Nicola , ORZI, Fabrizio
IPC分类号： C07D207/34
CPC分类号： C07D403/14 , C07D207/34
摘要： A process for preparing distamycin derivatives possessing antitumor activity, by starting from distamycin A itself, is described. The process involves the preparation of the novel intermediates of formula (III).
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公开(公告)号：EP1317287A2
公开(公告)日：2003-06-11
申请号：EP01969356.3
申请日：2001-07-09
发明人： SUARATO, Antonino , ANGELUCCI, Francesco , CARUSO, Michele , SCOLARO, Alessandra , VOLPI, Daniele , ZAMAI, Moreno
IPC分类号： A61K47/48
CPC分类号： A61K47/58 , A61K47/54 , A61K47/542 , A61K47/65
摘要： Water soluble polymeric conjugates of antitumor agents of formula (A) P-[W2]p-S0-[W1]r-[D] wherein:P is a water soluble polymer;[W1] is a residue of formula -HN-Z1-CO- in which Z1 represents a linear or branched C2-C12 alkylene chain or the residue of formula -C6H4-CH2-O-; [W2] is a residue of formula -HN-Z2-CO- in which Z2 represents a C2-C12 linear or branched alkylene chain;p and r are 0 or 1;S0 is a peptide that selectively is cleaved at the tumor site mainly by the action of the matrix metalloproteinases gelatinase; [D] is the residue of an antitumor agent.The conjugates possess enhanced antitumor activity and decreased toxicity with respect to the free drug. A process for their preparation, useful intermediates and pharmaceutical compositions containing them are also described.
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公开(公告)号：EP1317270A1
公开(公告)日：2003-06-11
申请号：EP01969689.7
申请日：2001-08-31
发明人： DI SALLE, Enrico , PISCITELLI, Gabriella , MASSIMINI, Giorgio , PURANDARE, Dinesh , MARTINI, Alessandro , MUGGETTI, Lorena
IPC分类号： A61K31/5685 , A61P35/00
CPC分类号： A61K45/06 , A61K31/5685 , A61K2300/00
摘要： The present invention concerns the use of aromatase inhibitor exemestane, either alone or in combination with other therapeutic agents, in the chemoprevention of estrogen dependent cancer in mammals, including humans, at increased risk of the disease.
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公开(公告)号：EP1311481A1
公开(公告)日：2003-05-21
申请号：EP01960493.3
申请日：2001-07-12
发明人： BERIA, Italo , COZZI, Paolo , MONGELLI, Nicola , NESI, Marcella
IPC分类号： C07D207/34
CPC分类号： C07D207/34
摘要： Herewith provided is a process for preparing useful intermediates in the preparation of distamycin derivatives possessing antitumor activity, said derivatives having the formula reported in the specification, by using distamycin A as the starting material.
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98.发明公开AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS 有权氮杂吲哚衍生物，其制造方法及其作为抗肿瘤药
公开(公告)号：EP1309590A1
公开(公告)日：2003-05-14
申请号：EP01943522.1
申请日：2001-06-13
发明人： LONGO, Antonio , BRASCA, Maria, Gabriella , ORSINI, Paolo , TRAQUANDI, Gabriella , PITTALA', Valeria , VULPETTI, Anna , VARASI, Mario , PEVARELLO, Paolo
IPC分类号： C07D471/04 , A61K31/437 , A61P35/04
CPC分类号： C07D471/04
摘要： Novel 1H-pyrrolo[2,3-b]pyridines which are represented by formula (I), as per the specification, and wherein R is a hydrogen or halogen atom or a group selected from -CN, -OH, -OCOR4, -(CH2)nNH2, -(CH2)nNHR4, -(CH2)nNHCOR4, -(CH2)nNHCONR4R5, -(CH2)nNHCOOR4, or -(CH2)nNHSO2R4, wherein n is either 0 or 1, R4 and R5 are as described in the specification; R1 is hydrogen or an optionally substituted alkyl group; R¿2? is an optionally substituted group selected from alkyl or aryl; R3 is hydrogen or a group selected from -CONR4R5, -COOR4, -CONHOR4, -SO2NHR4, alkylsulphonylaminocarbonyl or perfluorinated alkylsulphonylaminocarbonyl; or a pharmaceutically acceptable salt thereof, are disclosed; these compounds are useful for treating cell proliferative disorders associated with an altered cell cycle dependent kinase activity.
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公开(公告)号：EP0659435B1
公开(公告)日：2003-05-14
申请号：EP95101919.9
申请日：1987-12-03
发明人： Gatti, Gaetano , Oldani, Diego , Bottoni, Giuseppe , Confalonieri, Carlo , Gambini, Luciano , De Ponti, Roberto
IPC分类号： A61K31/704 , A61K9/08 , A61P35/00
CPC分类号： A61K9/0019 , A61K9/08 , A61K31/70 , A61K31/704 , A61K47/26
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公开(公告)号：EP0941081B1
公开(公告)日：2003-01-15
申请号：EP97951157.3
申请日：1997-11-10
发明人： ANELLI, Marco , STRUMIA, Ettore
CPC分类号： A61K31/198
摘要： Description of a new use of creatine in the preparation of a drug for the treatment of cardiac and/or respiratory insufficiency.
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