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1.发明公开3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权3（5） - 氨基 - 吡唑衍生物，它们的制备方法和用途作为抗癌药
公开(公告)号：EP1202733A1
公开(公告)日：2002-05-08
申请号：EP00931906.2
申请日：2000-05-05
发明人： PEVARELLO, Paolo , ORSINI, Paolo , TRAQUANDI, Gabriella , VARASI, Mario , FRITZEN, Edward, L. , WARPEHOSKI, Martha, A. , PIERCE, Betsy, S. , BRASCA, Maria, Grabriella
IPC分类号： A61K31/415 , C07D231/40
CPC分类号： C07D403/12 , A61K31/415 , A61K31/4155 , A61K45/06 , C07D231/16 , C07D231/40 , C07D405/12 , C07D409/12
摘要： Compounds which are 3-amino-pyrazole derivatives represented by formula (I) wherein R is C3-C6 cycloalkyl group optionally substituted by a straight or branched C1-C6 alkyl or arylalkyl group; R1 is a straight or branched C1-C6 alkyl, C2-C4 alkenyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, arylalkyl, arylcarbonyl, aryloxyalkyl or arylalkenyl group, each of which may be optionally further substituted as indicated in the description; or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.
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2.发明公开3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权3（5） - 脲基 - 吡唑衍生物，它们的制备方法和用途作为抗癌药
公开(公告)号：EP1202734A1
公开(公告)日：2002-05-08
申请号：EP00955241.5
申请日：2000-08-11
发明人： PEVARELLO, Paolo , ORSINI, Paolo , TRAQUANDI, Gabriella , VARASI, Mario , FRITZEN, Edward, L. , WARPEHOSKI, Martha, A. , PIERCE, Betsy, S.
IPC分类号： A61K31/415 , A61K31/496 , C07D231/40 , C07D403/12
CPC分类号： C07D231/40 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/5377
摘要： 3-ureido-pyrazole derivatives represented by formula (I): where R, R1 and R2 are as described herein, or pharmaceutically acceptable salts thereof; are useful, for example, for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.
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3.发明授权3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权3（5） - 氨基 - 吡唑衍生物，它们的制备方法和用途作为抗癌药
公开(公告)号：EP1202733B1
公开(公告)日：2005-10-05
申请号：EP00931906.2
申请日：2000-05-05
发明人： PEVARELLO, Paolo , ORSINI, Paolo , TRAQUANDI, Gabriella , VARASI, Mario , FRITZEN, Edward, L. , WARPEHOSKI, Martha, A. , PIERCE, Betsy, S. , BRASCA, Maria, Grabriella
IPC分类号： A61K31/415 , C07D231/40 , C07D231/16
CPC分类号： C07D403/12 , A61K31/415 , A61K31/4155 , A61K45/06 , C07D231/16 , C07D231/40 , C07D405/12 , C07D409/12
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4.发明公开SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS 有权作为激酶抑制剂的合适的取代PYRROLOPYRAZOLDERIVATE
公开(公告)号：EP1575954A2
公开(公告)日：2005-09-21
申请号：EP03799536.2
申请日：2003-12-04
发明人： BRASCA, Maria, Gabriella , AMICI, Raffaella , FANCELLI, Daniele , NESI, Marcella , ORSINI, Paolo , ORZI, Fabrizio , ROUSSEL, Patrick , VULPETTI, Anna , PEVARELLO, Paolo
IPC分类号： C07D487/00
CPC分类号： C07D487/04 , A61K31/4162 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , A61N5/10
摘要： Compounds represented by formula (Ia) or (lb) and wherein R and R1 are as defined in the description, and pharmaceutically acceptable salts thereof, are disclosed; the said compounds are useful in the treatment of cell cycle proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
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5.发明公开CHROMANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 审中-公开色，其制造方法相同，它们作为抗肿瘤药
公开(公告)号：EP1379524A2
公开(公告)日：2004-01-14
申请号：EP02719710.2
申请日：2002-01-17
发明人： TRAQUANDI, Gabriella , BRASCA, Maria, Gabriella , ORSINI, Paolo , PIUTTI, Claudia , VULPETTI, Anna , PEVARELLO, Paolo
IPC分类号： C07D405/12 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , A61K31/4155 , A61P35/00
CPC分类号： C07D401/12 , A61K31/415 , A61K31/47 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： Compounds which are chromane derivatives of formula (I), pharmaceutically acceptable salts, process for their preparation and pharmaceutical compositions thereof are disclosed, as set forth in the specification; these compounds are useful in therapy in the treatment of cell proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
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6.发明公开
公开(公告)号：EP1345909A1
公开(公告)日：2003-09-24
申请号：EP01983600.6
申请日：2001-11-22
发明人： PEVARELLO, Paolo , ORSINI, Paolo , TRAQUANDI, Gabriella , BRASCA, Maria, Gabriella , AMICI, Raffaella , VILLA, Manuela , PIUTTI, Claudia , VARASI, Mario , LONGO, Antonio
IPC分类号： C07D231/40 , C07D413/12 , C07D403/12 , C07D401/12 , A61K31/415 , A61P35/00
CPC分类号： C07D401/12 , C07D231/40 , C07D403/12 , C07D413/12
摘要： Phenylacetamido-pyrazoles of Formula (I) and, more particularly, N-(5-cycloalkyl-1H-pyrazol-3-yl) phenylacetamido derivatives, optionally further substituted as reported in the description; or pharmaceutically acceptable salts thereof; are useful in the treatment of cell proliferative disorders, e.g.cancer, associated with an altered cell cycle dependent kinase activity. Formula (I).
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7.发明公开
公开(公告)号：EP1660475A1
公开(公告)日：2006-05-31
申请号：EP04763883.8
申请日：2004-08-06
发明人： VANOTTI, Ermes , D'ALESSIO, Roberto , TIBOLLA, Marcellino , VARASI, Mario , MONTAGNOLI, Alessia , SANTOCANALE, Corrado , ORSINI, Paolo , PILLAN, Antonio
IPC分类号： C07D401/04 , C07D519/00 , A61K31/506 , A61K31/52 , A61P35/00 , A61P25/28 , A61P31/12 , A61P37/00 , A61P13/08 , A61P17/06 , A61P9/10 , A61P11/00 , A61P19/02 , A61P13/12 , A61K45/06
CPC分类号： C07D471/04 , A61K31/506 , A61K31/513 , A61K31/52 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： Pyrimidylpyrrole derivatives of formula (1) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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8.发明公开AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS 有权氮杂吲哚衍生物，其制造方法及其作为抗肿瘤药
公开(公告)号：EP1309590A1
公开(公告)日：2003-05-14
申请号：EP01943522.1
申请日：2001-06-13
发明人： LONGO, Antonio , BRASCA, Maria, Gabriella , ORSINI, Paolo , TRAQUANDI, Gabriella , PITTALA', Valeria , VULPETTI, Anna , VARASI, Mario , PEVARELLO, Paolo
IPC分类号： C07D471/04 , A61K31/437 , A61P35/04
CPC分类号： C07D471/04
摘要： Novel 1H-pyrrolo[2,3-b]pyridines which are represented by formula (I), as per the specification, and wherein R is a hydrogen or halogen atom or a group selected from -CN, -OH, -OCOR4, -(CH2)nNH2, -(CH2)nNHR4, -(CH2)nNHCOR4, -(CH2)nNHCONR4R5, -(CH2)nNHCOOR4, or -(CH2)nNHSO2R4, wherein n is either 0 or 1, R4 and R5 are as described in the specification; R1 is hydrogen or an optionally substituted alkyl group; R¿2? is an optionally substituted group selected from alkyl or aryl; R3 is hydrogen or a group selected from -CONR4R5, -COOR4, -CONHOR4, -SO2NHR4, alkylsulphonylaminocarbonyl or perfluorinated alkylsulphonylaminocarbonyl; or a pharmaceutically acceptable salt thereof, are disclosed; these compounds are useful for treating cell proliferative disorders associated with an altered cell cycle dependent kinase activity.
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